Polysaccharide Constituents of Three Types of Sea Urchin Shells and Their Anti-Inflammatory Activities

Jiao, Heng; Shang, Xiaohui; Dong, Qi; Wang, Shuang; Liu, Xiaoyu; Zheng, Heng; Lü, Xiaoling

doi:10.3390/md13095882

Cited by 15 publications

(8 citation statements)

References 10 publications

(10 reference statements)

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“…Sea urchins are renewable marine species, which are commercially harvested and processed in the food industry and cosmetics, and have a great potential for the development of medicines. All parts of these unique organisms including the body wall, gonads, coelomic fluid, and internal organs show a high medicinal value [1,2,3,4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach

Shikov

Pozharitskaya²,

Фаустова³

et al. 2019

Marine Drugs

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A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i/n) administration over the course of seven days in rats. The method measuring lactate dehydrogenase as biomarker was used to analyse the plasma and tissue concentrations of GPF. GPF appears in the plasma 15 min after single i/n administration (100 µg/kg) and reaches its maximum at 45 min. The area under the curve (AUC)0–24 and Cmax were similar using both i/n and intravenous administration, while mean residence time (MRT) and T1/2 after i/n administration were significantly higher compared with intravenous (i/v) administration. The absolute bioavailability of GPF after i/n administration was 89%. The values of tissue availability (ft) provided evidence about the highest concentration of GPF in the nose mucosa (ft = 34.9), followed by spleen (ft = 4.1), adrenal glands (ft = 3.8), striated muscle (ft = 1.8), kidneys (ft = 0.5), and liver (ft = 0.3). After repeated dose administration, GPF exhibited significantly higher AUC0–24 and MRT, indicating its accumulation in the plasma.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach

Shikov

Pozharitskaya²,

Фаустова³

et al. 2019

Marine Drugs

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“…Korean researchers showed the anti‐diabetic effect of powdered sea urchin shells on type 2 diabetic rats . Minerals from the shells can be used for replacing and reconstruction of damaged or defective hard tissue; polysaccharides from the shells possess an anti‐inflammatory effect; and proteins from the shells and spines demonstrate antitumour activity . Secondary metabolites specific to sea urchins – polyhydroxynaphthoquinones (PHNQs) – also exhibit a wide range of pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Diversity of Polyhydroxynaphthoquinone Pigments in North Pacific Sea Urchins

Васильева

Mishchenko

Fedoreyev

2017

Chemistry & Biodiversity

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Using high-performance liquid chromatography with diode-array detection and mass spectrometry (HPLC-DAD/MS) we investigated the composition of polyhydroxynaphthoquinone (PHNQ) pigments from sea urchins Strongylocentrotus pallidus, St. polyacanthus, St. droebachiensis, Brisaster latifrons and Echinarachnius parma, collected in the Sea of Okhotsk and the Bering Sea. Identification of PHNQ pigments from sea urchins St. polyacanthus, B. latifrons, and E. parma was performed for the first time. Among the usual PHNQ pigments, mono- and dimethoxy derivatives of spinochrome E, not previously found in other sea urchins, were discovered in St. polyacanthus and St. droebachiensis. In St. droebachiensis, two monomethoxy derivatives of echinochrome A were detected, isolated previously from only tropical sea urchins. It was found that the composition and total content of pigments of St. droebachiensis depends on the collection area of the sea urchins and its depth and varies from 88 to 331 μg/g of dry shells. Sea urchins St. pallidus, B. latifrons and E. parma had average values for PHNQ pigment content, approximately 30 μg/g, and St. polyacanthus had a low PHNQ content, 13 μg/g.

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“…Some families such as Diadematidae, Echinothuriidae, and Toxopneustidae contain venoms (Thiel and Watling 2015). The main MNPs of sea urchins are proteins, polysaccharides, and pigments, which are located in the spines, testes, gonads, and/or pedicellaria (Shang et al 2014;Jiao et al 2015). Studies on their MNPs have mainly focused on proteins derived from naphthoquinone pigments that showed antibacterial, antioxidant, and anti-inflammatory activities.…”

Section: Echinoids (Sea Urchins)mentioning

confidence: 99%

Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea)

Kamyab

Kellermann

Kunzmann

et al. 2019

YOUMARES 9 - The Oceans: Our Research, Our Future

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Echinoderms are a source of a broad range of secondary metabolites with a large variety of bioactive properties. Although pigment and lipid derivatives are the major groups of bioactive compounds found in crinoids and ophiuroids, saponins represent the most abundant and diverse marine natural products (MNPs) in the phylum Echinodermata. This review is for researchers that are interested in MNPs derived from echinoderms, but with a particular focus on the structural diversity and biological function of saponins. Among the echinoderms, these steroidal compounds are mostly known for and structurally most diverse within sea cucumbers. Through compilation of extensive tables, this review provides a reference book, summarizing not only the major chemical classes of well-known secondary metabolites in the phylum Echinodermata but also further focusing on the presence of bioactive saponins in echinoderms in general and within different sea cucumber species in particular. The final compilation aims to correlate the vast structural diversity of saponins with known biological functions. The here presented data revealed that holothurians, holotoxins, cucumariosides, and echinosids are not only the most abundant saponin compounds in various genera of sea cucumbers but that these saponins can also be used as potential chemotaxonomic markers for different sea cucumber species. By studying the structure-function relationships of triterpene glycosides in echinoderms in general, or in particular within holothurians, the vast structural diversity, taxonomic distribution, and bioactivity of the molecules can be deciphered, which provides an opportunity to focus future research efforts on target species that contain MNPs with novel pharmacological activities.

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Polysaccharide Constituents of Three Types of Sea Urchin Shells and Their Anti-Inflammatory Activities

Cited by 15 publications

References 10 publications

Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach

Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach

Diversity of Polyhydroxynaphthoquinone Pigments in North Pacific Sea Urchins

Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea)

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