Bioactive triterpenoids from Callistemon lanceolatus

Abstract

A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC(50) value of 15.4 microM.

Cardioprotective activity of ethanolic extract of Callistemon lanceolatus leaves on doxorubicin-induced cardiomyopathy in rats

“…The essential oils from leaves possess antimicrobial, fungitoxic, antinociceptive and anti-inflammatory activities. Several triterpenoids, flavonoides, fatty acids, tannins and phenolic compounds have been isolated from its leaves (Sudhakar et al, 2004;Jeong et al, 2009). The leaves was also reported for its hepatoprotective effect (Jain et al, 2007), antidiabetic, hypolipidemic and anti-oxidant activity (Kumar et al, 2011).…”

A novel approach for the biosynthesis of silver oxide nanoparticles using aqueous leaf extract ofCallistemon lanceolatus(Myrtaceae) and their therapeutic potential

“…[41] This plant is known for several medicinal properties, viz., anti-inflammatory properties [42] and inhibition of anticholinesterase activity. [43] It is known to contain several volatile oils, [44] polyphenols [41,45] and triterpenoids [46,47] which might be responsible for its medicinal properties. Hence, in this study, we have demonstrated the biological synthesis of silver oxide nanoparticles using the aqueous extract of C. lanceolatus and reported their significant antioxidant and cytotoxic activity.…”

Phenolic Compounds From Callistemon Citrinus Leaves and Stems

“…Species Callistemon citrinus (Curtis) Skeels, local name "Tram bong do", is grown as ornaments in Vietnam for its beautiful form, glossy green foliage and red, bottle-brush like flowers. Phytochemical studies of Callistemon species have led to the isolation and characterization of flavones [2], acylphloroglucinols [3,4], triterpenoids [5], neolignans [6], essential oil, steroids and saponins [7].…”

“…In this study, we describe the isolation and structural elucidation of eight phenolic compounds, including two flavones (eucalyptin (1) and 8-demethyleucalyptin (2)), two alcohols (blumenol A (3), tetratriacontan-1-ol (4)), three benzoic acid derivatives (gallic acid (5), methyl gallate (6) and protocatechuic acid (7)), one sterol (β-stigmasterol (8)) along with one sesquiterpene (2,6,10-bisabolatriene (9)). The structures of the natural compounds were identified by spectroscopic evidences including 1D-and 2D-NMR and ESI-MS.…”