“…Some of these cues are in the form of polypeptide motifs on extracellular matrix proteins or on membrane bound molecules of neighboring cells. In addition to intact cell adhesion proteins, such as collagen and fibronectin (Ignatius et al, 1998), several groups have employed cell adhesion peptides, such as RGD (Kam et al, 2002), found in many extracellular proteins, YIGSR (Kam et al, 2002;, and IKVAV (Kam et al, 2002), found in laminin and KHIFS-DDSSE (Kam et al, 2002), found on NCAM (neural-cell adhesion molecule). Studies to establish neuronal reactions to these proteins and peptides have been conducted in vitro.…”