Bioactive superparamagnetic iron oxide-gold nanoparticles regulated by a dynamic magnetic field induce neuronal Ca2+ influx and differentiation

Georgas, Elias; Chen, Jingfan; Wang, Ya; Qin, Yi‐Xian

doi:10.1016/j.bioactmat.2023.01.007

Cited by 8 publications

(4 citation statements)

References 66 publications

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“…To further investigate synaptic plasticity, we also studied the expression of β3-TUBULIN, a marker of neurite outgrowth that has been reported to be regulated by Ca 2+ under electrical and magnetic stimulation [22,30]. We also investigated NEFL, a cytoskeletal protein induced rapidly during synaptic plasticity and with a CREB-binding site in its promoter region [19], and the neurotrophic factor BDNF involved in neuronal differentiation and known to be regulated by electrical stimulation and Ca 2+ influx [18,20,22].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Imaging and Molecular Characterization of Ca2+ Flux Modulation by Nanosecond Pulsed Electric Fields

Camera,

Colantoni,

Garcia-Sanchez

et al. 2023

IJMS

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In recent years, the application of pulsed electric fields with very short durations (nanoseconds) and extremely high amplitudes (MV/m) has been investigated for novel medical purposes. Various electric protocols have been explored for different objectives, including the utilization of fractionated pulse doses to enhance cell electrosensitization to the uptake of different markers or an increase in apoptosis. This study focused on the use of fluorescence imaging to examine molecular calcium fluxes induced by different fractionated protocols of short electric pulses in neuroblastoma (SH-SY5Y) and mesenchymal stem cells (HaMSCs) that were electroporated using nanosecond pulsed electric fields. In our experimental setup, we did not observe cell electrosensitization in terms of an increase in calcium flux following the administration of fractionated doses of nanosecond pulsed electric fields with respect to the non-fractionated dose. However, we observed the targeted activation of calcium-dependent genes (c-FOS, c-JUN, EGR1, NURR-1, β3-TUBULIN) based on the duration of calcium flux, independent of the instantaneous levels achieved but solely dependent on the final plateau reached. This level of control may have potential applications in various medical and biological treatments that rely on calcium and the delivery of nanosecond pulsed electric fields.

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Section: Discussionmentioning

confidence: 99%

In Vitro Imaging and Molecular Characterization of Ca2+ Flux Modulation by Nanosecond Pulsed Electric Fields

Camera,

Colantoni,

Garcia-Sanchez

et al. 2023

IJMS

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show abstract

“…Various MNPs have been considered for the carriers of chemotherapeutic drugs due to their advantages of enhanced bioavailability, minimal side effects, appropriate degradation, and targeted delivery [ [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] , [95] , [96] ]. Ferroptosis-induction cancer nanomedicines utilizing MNPs have been produced and tested, a summary of which is provided in Table 2 .…”

Section: Ferroptosis Inducers For Ferroptosis Cancer Therapymentioning

confidence: 99%

Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Ko,

Min,

Hong

et al. 2024

Bioactive Materials

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“…The tensile force generated by endocytosed NPs driven by an external static MFs could stretch the ends of neurites and align them toward the direction of MFs (Riggio et al, 2014). SPIO NPs with dynamic MFs have also proved to promote neuronal differentiation and neurite orientation through mechanisms of the cytoskeletal forces (Yuan et al, 2018) and the increased intracellular Ca 2+ concentration (Georgas et al, 2023).…”

Section: Superparamagnetic Iron Oxide and Magnetic Fieldsmentioning

confidence: 99%

Current advances in biomaterials for inner ear cell regeneration

Lu,

Wang,

Meng

et al. 2024

Front. Neurosci.

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Inner ear cell regeneration from stem/progenitor cells provides potential therapeutic strategies for the restoration of sensorineural hearing loss (SNHL), however, the efficiency of regeneration is low and the functions of differentiated cells are not yet mature. Biomaterials have been used in inner ear cell regeneration to construct a more physiologically relevant 3D culture system which mimics the stem cell microenvironment and facilitates cellular interactions. Currently, these biomaterials include hydrogel, conductive materials, magneto-responsive materials, photo-responsive materials, etc. We analyzed the characteristics and described the advantages and limitations of these materials. Furthermore, we reviewed the mechanisms by which biomaterials with different physicochemical properties act on the inner ear cell regeneration and depicted the current status of the material selection based on their characteristics to achieve the reconstruction of the auditory circuits. The application of biomaterials in inner ear cell regeneration offers promising opportunities for the reconstruction of the auditory circuits and the restoration of hearing, yet biomaterials should be strategically explored and combined according to the obstacles to be solved in the inner ear cell regeneration research.

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Bioactive superparamagnetic iron oxide-gold nanoparticles regulated by a dynamic magnetic field induce neuronal Ca2+ influx and differentiation

Cited by 8 publications

References 66 publications

In Vitro Imaging and Molecular Characterization of Ca2+ Flux Modulation by Nanosecond Pulsed Electric Fields

In Vitro Imaging and Molecular Characterization of Ca2+ Flux Modulation by Nanosecond Pulsed Electric Fields

Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Current advances in biomaterials for inner ear cell regeneration

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