Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Ko, Min Jun; Min, Sunhong; Hong, Hyunsik; Yoo, Woojung; Joo, Jinmyoung; Zhang, Yu Shrike; Kang, Heemin; Kim, Dong-Hyun

doi:10.1016/j.bioactmat.2023.09.015

Cited by 12 publications

(3 citation statements)

References 228 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The challenges that may exist in the short term are: our current understanding of the pathogenesis of infectious and inflammatory diseases is not sufficiently deep or does not allow us to cope with rapidly changing conditions; the differentiation between animal models and the realities of the human body poses a challenge; 659 – 662 and the technology for clinical design and translation needs to be improved. 663 – 665 …”

Section: The Limitations/challenges Of Nanotechnology Applicationmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new pathogens, increasing drug resistance, changes in living environments and lifestyles, and the aging population. Despite rapid advancements in mechanistic research and drug development for these diseases, current treatments often have limited efficacy and notable side effects, necessitating the development of more effective and targeted anti-inflammatory therapies. In recent years, the rapid development of nanotechnology has provided crucial technological support for the prevention, treatment, and detection of inflammation-associated diseases. Various types of nanoparticles (NPs) play significant roles, serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability. NPs can also directly combat pathogens and inflammation. In addition, nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases. This review categorizes and characterizes different types of NPs, summarizes their applications in the prevention, treatment, and detection of infectious and inflammatory diseases. It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects. In conclusion, nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

show abstract

Section: The Limitations/challenges Of Nanotechnology Applicationmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

“…Precise manipulation of cellular behavior and molecular processes is achievable through the detailed design and control of macroscopic structures, molecular composition regulation, surface chemical modification, and nanoscale structural optimization. However, conventional nanomedicine literature in databases often follows a predictable pattern [ 222 , 282 , [397] , [398] , [399] ]. They introduce novel concepts or materials using illustrative diagrams, substantiated by cell culture data and animal models, showcasing impressive in vivo outcomes.…”

Section: Nanomedicine Based On Pdotsmentioning

confidence: 99%

Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

Zhang,

Yu,

et al. 2024

Materials Today Bio

View full text Add to dashboard Cite

“…Mitochondria are the primary source of ROS derived from mitochondrial respiration and are also considered as a core organelle involved in ferroptosis [126], an iron-dependent programmed form of cell death caused by lipid peroxidation [127,128], due to the dysregulation of iron homeostasis in iron-rich tumors, like BC, that are particularly sensitive to ferroptosis-targeted drugs [40]. The localized image-guided ferroptosis in cancer nanomedicine can be performed through the use of remotely controllable magnetic nanocarriers [129]. Moreover, Yu et al (2024) proposed a high intensity focused ultrasound (HIFU)-driven nanomotor (NP-G/P) based on PEGylated poly (lactic-co-glycolic acid) (PLGA) NPs loaded with perfluorooctyl bromide (PFOB) to endow responsiveness to HIFU forces for propulsion and on-demand drug release that activates ferroptosis-mediated antitumor immunity in primary and metastatic TNBC models, resulting in significant tumor regression and metastasis prevention [40].…”

Section: Anti-resisting Cell Death Nanomaterialsmentioning

confidence: 99%

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Neagu,

Jayaweera,

Weraduwage

et al. 2024

IJMS

View full text Add to dashboard Cite

We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice.

show abstract

Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Cited by 12 publications

References 228 publications

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Contact Info

Product

Resources

About