Bioactive Secondary Metabolites from Schizogyne sericea (Asteraceae) Endemic to Canary Islands

Abstract

Schizogyne sericea (Asteraceae) is a halophytic shrub endemic to the Canary Islands and traditionally employed as analgesic, astringent, anti-inflammatory, and vulnerary. A comprehensive phytochemical investigation was conducted on the flowering aerial parts by analyzing both essential oil constituents and polar compounds. The essential oil was dominated by p-cymene, with the noteworthy occurrence of β-pinene and thymol esters. From the EtOH extract, eight compounds were isolated and structurally elucidated. Essential oil, polar fractions, and isolates (2), (4), and (5) were separately in vitro assayed for antiproliferative activity on human tumor cell lines (A375, MDA-MB 231, and HCT116) by MTT assay, for antioxidant potential by DPPH, ABTS, and FRAP assays, and for antimicrobial activity by the agar disk diffusion method. Results revealed that essential oil and compounds 1 and 2 exert a strong inhibition on tumor cells, and in some cases, higher than that of cisplatin. Fractions containing thymol derivatives (1 and 2) and caffeoylquinic acid derivatives 4 and 5 displayed antioxidant activity comparable to that of Trolox, making S. sericea extract an interesting natural product with potential applications as preservative or in the treatment of diseases in which oxidative stress plays an important role.

Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

“…However, as the hydrophobic nature of CSEO, for its practical administration in vivo or clinical trials, it should be formulated; thus, its nanoformulated form (CSChiNPs) was the best sample against A-375 cells. Interestingly, IC 50 s of CSChiNPs and CLChiNPs (0.03 and 0.124 μg/mL) against A-375 were more potent than cisplatin with IC 50 of 0.40–0.45 μg/mL [ 29 , 44 ]. Their efficacies against MDA-MB-468 (23.65 and 40.32 μg/mL) were also comparable or more potent than cisplatin (IC 50 32.50 μg/mL) [ 45 ].…”

MeJA Elicitation of Chicory Hairy Roots Promotes Efficient Increase of 3,5-diCQA Accumulation, a Potent Antioxidant and Antibacterial Molecule

“…A number of studies have shown a lack or a weak antibacterial activity of this metabolite against P. aeruginosa [ 46 , 47 ], however, others studies have found approximately MIC values similar to ours of di-CQA against P. aeruginosa . It is the case with the study of Venditti et al [ 48 ] but merely the study of Lehbili et al [ 49 ] also using a multiple inoculator and indicating a MIC value of 125 µg·mL −1 , but results may be strain-dependent.…”

Exploring the Insecticidal Potential of Boldo (Peumus boldus) Essential Oil: Toxicity to Pests and Vectors and Non-target Impact on the Microcrustacean Daphnia magna

“…p -Cymene is an aromatic monoterpene occurring in high levels in the essential oil from Schizogyne sericea (L.f.) DC [36] and functions as precursors of phenolics as thymol and carvacrol [37,38,39,40]. It is a strong perturbator of cell membrane and can synergize the effects of other active compounds, such as ascaridole [26,38,39,40].…”