Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

Alipanah, Hiva; Farjam, Mojtaba; Zarenezhad, Elham; Roozitalab, Ghazaal; Osanloo, Mahmoud

doi:10.1186/s12906-021-03362-7

Cited by 39 publications

(20 citation statements)

References 38 publications

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“…Similar results were obtained by Yang et al (2017), who reported the antiproliferative activity of orange oil containing limonene against A549 human lung cancer cells and 22RV-1 prostate cancer cells [18]. An antiproliferative effect of the orange essential oil against A375 cells was also reported [46,53] but at higher concentrations than the ones tested in the present study.…”

Section: The Impact Of the First Compounds On Human Squamous Tongue Carcinoma Cells-scc-4 Viability And Morphologysupporting

confidence: 92%

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In Vitro Assessment of the Cytotoxic and Antiproliferative Profile of Natural Preparations Containing Bergamot, Orange and Clove Essential Oils

et al. 2022

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Medicinal plants and essential oils (EOs), in particular, were intensively studied in recent years as viable alternatives for antiproliferative chemical synthetic agents. In the same lines, the present study focuses on investigating the effects of natural preparations (emulsions) based on EOs obtained from Citrus bergamia Risso (bergamot-BEO), Citrus sinensis Osbeck (orange-OEO), and Syzygium aromaticum Merill et L. M. Perry (clove-CEO) on different healthy (human immortalized keratinocytes—HaCaT and primary human gingival fibroblasts—HGF) and human tumor cell lines (human melanoma—A375 and oral squamous carcinoma—SCC-4) in terms of the cells’ viability and cellular morphology. The obtained results indicate that the CEO emulsion (ECEO) induced a dose-dependent cytotoxic in both healthy (HaCaT and HGF) and tumor (A375 and SCC-4) cells. OEO emulsion (EOEO) increased cell viability percentage both for HaCaT and A375 cells and had an antiproliferative effect at the highest concentration in HGF and SCC-4 cells. BEO emulsion (EBEO) decreased the viability percentage of SCC-4 tumor cells. By associating OEO with CEO as a binary mixture in an emulsified formulation, the inhibition of tumor cell viability increases. The E(BEO/OEO) binary emulsion induced an antiproliferative effect on oral health and tumor cells, with a minimal effect on skin cells. The non-invasive tests performed to verify the safety of the test compound’s emulsions at skin level indicated that these compounds do not significantly modify the physiological skin parameters and can be considered safe for human skin.

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Section: The Impact Of the First Compounds On Human Squamous Tongue Carcinoma Cells-scc-4 Viability And Morphologysupporting

confidence: 92%

“…To correct these inconveniences, several new formulations were proposed to increase the efficacy of these EOs and to minimize their toxicity [46,47].…”

Section: The Impact Of the First Compounds On Human Squamous Tongue Carcinoma Cells-scc-4 Viability And Morphologymentioning

confidence: 99%

In Vitro Assessment of the Cytotoxic and Antiproliferative Profile of Natural Preparations Containing Bergamot, Orange and Clove Essential Oils

et al. 2022

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“…As detailed in our previous report, limonene was identified as the major compound in the used EOs; it composed 31.4, 61.8, and 61.8% of identified compounds in C. aurantium , C. limon , and C. sinensis EOs [ 31 ]. Sabinene (15.6%), ɣ-terpinene (6.0%), linalool (5.6%), and nerolidol (5.1%) were the other four major compounds of C. aurantium EO.…”

Section: Discussionmentioning

confidence: 99%

Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors

Sanei-Dehkordi

Moemenbellah‐Fard

Saffari

et al. 2022

BMC Complement Med Ther

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Background Mosquito-borne diseases such as malaria and encephalitis are still the cause of several hundred thousand deaths annually. The excessive use of chemical insecticides for transmission control has led to environmental pollution and widespread resistance in mosquitoes. Botanical insecticides' efficacies improvement has thus received considerable attention recently. Methods The larvicidal effects of three essential oils from the Citrus family and limonene (their major ingredient) were first investigated against malaria and filariasis mosquito vectors. An attempt was then made to improve their efficacies by preparing nanoliposomes containing each of them. Results The larvicidal effect of nanoformulated forms was more effective than non-formulated states. Nanoliposomes containing Citrus aurantium essential oil with a particle size of 52 ± 4 nm showed the best larvicidal activity (LC50 and LC90 values) against Anopheles stephensi (6.63 and 12.29 µg/mL) and Culex quinquefasciatus (4.9 and 16.4 µg/mL). Conclusion Due to the green constituents and high efficacy of nanoliposomes containing C. aurantium essential oil, it could be considered for further investigation against other mosquitoes’ populations and field trials.

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“…Some of the propolis compounds have shown biological activity, such as chrysin, which has been shown to stimulate IL‐2 and IL‐10 expression in murine melanoma cells, and galangin, which downregulates ERK 1/2 and activates p38 MAP kinases in human melanoma cells. Chitosan nanoparticles containing limonene and limonene‐rich essential oils ( Citrus sinensis and Citrus limon ) showed viability reduction on melanoma cell line A375, but the mechanism is unknown 40 …”

Section: Resultsmentioning

confidence: 99%

Complementary and alternative therapies in skin cancer a literature review of biologically active compounds

Hidalgo

Saldías-Fuentes²,

Carrasco

et al. 2022

Dermatologic Therapy

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Complementary and alternative medicine or therapies (CAM) are frequently used by skin cancers patients. Patient's self-administration of CAM in melanoma can reach up to 40%-50%. CAMs such as botanical agents, phytochemicals, herbal formulas ("black salve") and cannabinoids, among others, have been described in skin cancer patients.The objective of this review article was to acknowledge the different CAM for skin cancers through the current evidence, focusing on biologically active CAM rather than mind-body approaches. We searched MEDLINE database for articles published through July 2022, regardless of study design. Of all CAMs, phytochemicals have the best in vitro evidence-supporting efficacy against skin cancer including melanoma; however, to date, none have proved efficacy on human patients. Of the phytochemicals, Curcumin is the most widely studied. Several findings support Curcumin efficacy in vitro through various molecular pathways, although most studies are in the preliminary phase. In addition, the use of alternative therapies is not exempt of risks physicians should be aware of their adverse effects, interactions with standard treatments, and possible complications arising from CAM usage. There is emerging evidence for CAM use in skin cancer, but no human clinical trials support the effectiveness of any CAM in the treatment of skin cancer to date. Nevertheless, patients worldwide frequently use CAM, and physicians should educate themselves on currently available CAMs.

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Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

Cited by 39 publications

References 38 publications

In Vitro Assessment of the Cytotoxic and Antiproliferative Profile of Natural Preparations Containing Bergamot, Orange and Clove Essential Oils

In Vitro Assessment of the Cytotoxic and Antiproliferative Profile of Natural Preparations Containing Bergamot, Orange and Clove Essential Oils

Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors

Complementary and alternative therapies in skin cancer a literature review of biologically active compounds

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