Bioactive potential and composition analysis of sulfated polysaccharide from Acanthophora spicifera (Vahl) Borgeson

Javee, Anand; Sathuvan, Malairaj; Babu, Gopal Venkatesh; Muthu, Sakthivel; Palani, P.; Nagaraj, S.

doi:10.1016/j.ijbiomac.2018.01.057

Cited by 35 publications

(17 citation statements)

References 31 publications

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“…Moreover, a weak band at approximately 860 cm −1 in GUPS-II was attributed to α-glycosidic linkages in the polysaccharide chains. Another weak band at 1250-1244 cm −1 in GUPS-III was regarded as the S=O vibration, suggesting that GUPS-III may consist of sulfated polysaccharides [39][40][41]. This is in consistent with the sulfate content of GUPS-III.…”

Section: The Analysis Of Gups By Ft-ir Spectroscopysupporting

confidence: 56%

Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis

et al. 2020

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Glycyrrhiza uralensis is a Chinese herbal medicine with various bioactivities. Three fractions (GUPS-I, GUPS-II and GUPS-III) of G. uralensis polysaccharides (GUPS) were obtained with molecular weights of 1.06, 29.1, and 14.9 kDa, respectively. The monosaccharide compositions of GUPS-II and GUPS-III were similar, while that of GUPS-I was distinctively different. The results of scanning electron microscopy, FT-IR, and NMR suggested that GUPS-II and GUPS-III were flaky with a smooth surface and contained α- and β-glycosidic linkages, while GUPS-I was granulated and contained only α-glycosidic linkages. Moreover, GUPS-II and GUPS-III exhibited better bioactivities on the maturation and cytokine production of dendritic cells (DCs) in vitro than that of GUPS-I. An in vivo experiment showed that only GUPS-II significantly enhanced the maturation of DCs. These results indicate that GUPS-II has the potential to be used in combination with cancer immunotherapy to enhance the therapeutic effect.

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Section: The Analysis Of Gups By Ft-ir Spectroscopysupporting

confidence: 56%

Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis

et al. 2020

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“…The mixture was mechanically stirred at 4,000 rpm for 15 seconds and left in darkness for 30 minutes. Afterward, the absorbance was read at 520 nm (Anand et al, 2018;Lin et al, 2018). The quantification of sulfated sugars was carried out by the equation;…”

Section: Analysis Of Sugar Contentmentioning

confidence: 99%

Screening of the UV absorption capacity, proximal and chemical characterization of extracts, and polysaccharide fractions of the Gracilariopsis tenuifrons cultivated in Colombia

Monsalve-Bustamante¹,

Rincón-Valencia²,

Mejía-Giraldo³

et al. 2019

J App Pharm Sci

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The sustainable use of marine resources is a competitive advantage of the most developed countries, which has a positive impact on the economic and social development of their populations. Currently, marine organisms such as macroalgae are an important source of functional compounds such as polysaccharides, proteins, unsaturated and polyunsaturated fatty acids, among others, with nutritional value and pharmacological properties. Gracilariopsis tenuifrons is a macroalga found in the Colombian Caribbean Sea, which has been neither chemically nor physicochemically studied; therefore, the aim of this study was to evaluate the polysaccharides composition and nutrients contents of crude extract and its UV radiation absorption capacity. The purification was carried out by ultrafiltration using membranes of molecular size exclusion 100, 50, 10, and 3 kDa. The chemical characterization was done by gel electrophoresis, Nuclear Magnetic Resonance, Fourier Transform Infrared Spectroscopy, and the particle size and potential zeta by Dynamic Light Scattering. The absorption coefficient (absorbance/g dry sample) was measured at 290, 310, 340, and 380 nm. Sulfated and non-sulfated polysaccharides were detected in the fractions and identified as polysaccharides type k, and β-carrageenan and alginate. The proximate analysis showed that the total content of protein, carbohydrates, fat, and calories is 15.58%, 69.81%, 0.15%, and 342.94% Kcal, respectively. The crude extracts showed an important absorption coefficient in UVB-UVA range. The findings suggest that G. tenuifrons seaweed propagated in vitro is a viable candidate of natural additives, such as phycocolloids and bioactive compounds, for designing new functional products in the pharmaceutical and cosmetic industry, in addition to its nutritional properties to be used in foods.

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“…The sea harbors a natural compound that is promising to act as biologically active metabolites. Marine algae are highly studied for their potent antioxidant capability [7,8,9,10]. The seaweed bioactive compound can play a vital role in skincare formulation because of its antioxidant properties.…”

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confidence: 99%

Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum

Jesumani

Pei

et al. 2020

PLoS ONE

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Seaweed polyphenols and polysaccharide plays a broad range of biological activity. The objective of the present study was to study and compare the skin protection activity of fucoidan rich polysaccharide extract (SPS) and polyphenol-rich extract (SPP) from the seaweed Sargassum vachellianum. The skin protection activity was analyzed based on their ability to scavenge free radicals such as hydrogen peroxide and hydroxyl radicals, UV absorption potential, tyrosinase inhibition, moisture preservation, and antibacterial activity. From the results, both SPP and SPS protects the skin from UV damage. SPP showed good free radical scavenging ability, antimicrobial activity against E.coli and S. aureus and effectively absorbed the UVB and UVA rays whereas SPS hardly absorbs the UVA and UVB rays and showed weak free radical scavenging ability and no antimicrobial activity. SPS showed considerable inhibition on tyrosinase (51.21%) and had better moisture absorption (52.1%) and retention (63.24%) abilities than SPP. The results specified that both SPS and SPP have balancing potential on skin protection and suitable combinations of both could act as an active ingredient in cosmetics.calculating skin-lightening activity. In addition, Melanogenesis is described to result in the generation of free radicals like hydrogen peroxide in the melanocytes which again result in oxidative stress. Therefore ROS plays a significant role in the regulation of melanin synthesis and so ROS scavengers help in reduce the UV-induced melanogenesis [5]. Hyperpigmentation can be reduced by free radical scavengers and tyrosinase inhibitors that suppress melanogenesis in the skin [6]. Moisture absorption and retention capacity of the skin is getting disturbed due to age factor and exposure to environmental stress. Once the moisture in the skin is reduced, then the skin will become dry with wrinkles which also results in premature aging. Retaining moisture in the skin is also another important function of the skincare products. Compound that is rich in antioxidant activity associated with anti-tyrosinase and moisture-preserving properties and also has the ability to block the UV rays plays an important role in skin whitening and sunscreen products.Many synthetic chemicals like arbutin, hydroquinone and kojic acid are being used as tyrosinase inhibitors in skin whitening product, but it was testified to side effect like dermatitis, genotoxicity and also induce cancer. Hence, the exploration of an effective skin care agent is still continuing in cosmetic research. In recent years, natural products have become more attractive in the cosmetic industry due to no side effects. The sea harbors a natural compound that is promising to act as biologically active metabolites. Marine algae are highly studied for their potent antioxidant capability [7,8,9,10]. The seaweed bioactive compound can play a vital role in skincare formulation because of its antioxidant properties. The active compound protects the skin in several ways, which includes scavenging the ROS, supp...

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Bioactive potential and composition analysis of sulfated polysaccharide from Acanthophora spicifera (Vahl) Borgeson

Cited by 35 publications

References 31 publications

Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis

Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis

Screening of the UV absorption capacity, proximal and chemical characterization of extracts, and polysaccharide fractions of the Gracilariopsis tenuifrons cultivated in Colombia

Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum

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