Bioactive polysaccharides from medicinal mushrooms: A review on their isolation, structural characteristics and antitumor activity

Garcia, Juliana; Rodrigues, Francisca; Saavedra, Maria José; Nunes, Fernando M.; Marques, Guilhermina

doi:10.1016/j.fbio.2022.101955

Cited by 29 publications

(6 citation statements)

References 72 publications

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“…Thus, polysaccharides could mitigate the toxicities associated with overexpression of ROS and provide a potential therapeutic approach in the prevention of various human diseases [ 8 , 9 ]. Moreover, the interest in studying the biological activity of mushroom polysaccharides has increased, since it has been shown that they have anticancer activities or can improve the efficacy of conventional cancer treatments [ 10 , 11 ]. Three possible mechanisms by which polysaccharides have antitumor activity have been reported: (a) indirect activity through improving immunity function; (b) direct activity through inhibiting the growth of cancer cells; and (c) acting as a chemotherapy adjuvant [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Anticancer and Antioxidant Activity of Water-Soluble Polysaccharides from Ganoderma aff. australe against Human Osteosarcoma Cells

Muñoz-Castiblanco

Parra

Cañón

et al. 2022

IJMS

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Wild mushrooms have gained great importance for being a source of biologically active compounds. In this work, we evaluate the anticancer and antioxidant activity of a water-soluble crude polysaccharide extract isolated from the fruiting bodies of the Ganoderma aff. australe (GACP). This mushroom was collected in San Mateo (Boyacá, Colombia) and identified based on macroscopic and microscopic characterization. GACP was characterized by UV–Vis spectroscopy, Fourier-transform infrared spectroscopy, high-performance liquid chromatography–diode array detector, and nuclear magnetic resonance. The antiradical and antioxidant activity were evaluated by different methods and its anticancer activity was verified in the osteosarcoma MG-63 human cell line. Chemical and spectroscopic analysis indicated that GACP consisted of β-D-Glcp-(1→, →3)-β-D-Glcp-(1→ and α-D-Glcp-(1→ residues. The results of the biological activity showed that GACP exhibited high antioxidant activity in the different methods and models studied. Moreover, the results showed that GACP impaired cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay) and cell proliferation (clonogenic assay) in a dose–response manner on MG-63 cells. The findings of this work promote the use of mushroom-derived compounds as anticancer and antioxidant agents for potential use in the pharmaceutical and food industries.

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Section: Introductionmentioning

confidence: 99%

Anticancer and Antioxidant Activity of Water-Soluble Polysaccharides from Ganoderma aff. australe against Human Osteosarcoma Cells

Muñoz-Castiblanco

Parra

Cañón

et al. 2022

IJMS

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“…The results of monosaccharide composition analysis showed the highest glucose content (82.0%) in GAP-2, while numerous studies have shown that polysaccharides with higher b-glucan content may exhibit more significant biological activity, especially antitumor activity. [31][32][33][34]…”

Section: Monosaccharide Composition Determination Of Gap-2mentioning

confidence: 99%

Structural features and in vitro antitumor activity of a water-extracted polysaccharide from Ganoderma applanatum

et al. 2023

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“…Several fungi's bioactive components have attracted increasing interest in recent years as the idea of a healthy diet has grown in popularity. Polysaccharides are known to be significant active components in fungi, and they exhibit a wide range of biological properties, including immunomodulatory, antioxidant, anti‐tumour, hepatoprotective, hypolipidemic, and anticoagulant properties (Gunasekaran et al ., 2021a, 2021b; Garcia et al ., 2022; Nataraj et al ., 2022; Wang et al ., 2022). Many natural polysaccharides exhibit weak bioactivities, and thus, chemical modification of polysaccharides offers an approach to enhance their bioactivities by changing their structural and conformational properties (Wang et al ., 2018).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of physicochemical properties, antioxidant, antitumor, and anticoagulant activities via acetylation of Hypsizygus ulmarius polysaccharide

Thimmaraju

Govindan

Rajendran

et al. 2023

Int J of Food Sci Tech

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A polysaccharide (HUP1) was extracted and purified from Hypsizygus ulmarius fruiting bodies and further acetylated (Ac-HUP1) to improve their physicochemical properties and bioactivities. Chemical and FT-IR spectrum analyses results indicated differences in functionality and activity between HUP1 and Ac-HUP1, demonstrating the efficacy of the acetylation. HUP1 has an acetyl group with a degree of substitution (DS) 0.34. The molecular weight of the modified acetylated derivatives was reduced, according to the HPSEC findings. The native and acetylated polysaccharides included varying molar percentages of Ara, Man, Glu, GlcA, and GalA. The Ac-HUP1 outperformed HUP1 in antioxidant activity using the radical scavengers ABTS, DMPD, DPPH, superoxide, and OH radicals. In addition, Ac-HUP1 demonstrated higher activity in reducing power using Prussian blue, cupric ion, ferric ion, and phosphomolybdenum, as well as in lipid peroxidation inhibition assay. HUP1 and Ac-HUP1 inhibited five cancer cells (HT29, PC3, HeLa, Jurkat, and HepG-2) at concentrations from 10 to 320 lg mL À1 , and the impact was more pronounced in acetylated derivative, which was determined by MTT assay. Ac-HUP1, compared to HUP1, considerably prolonged the APTT, PT, and TT exhibiting anticoagulant activities. Therefore, acetylation modification may improve polysaccharide'sphysicochemical and biological characteristics, allowing them to be employed in the food, nutraceutical, and pharmaceutical industries.

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Bioactive polysaccharides from medicinal mushrooms: A review on their isolation, structural characteristics and antitumor activity

Cited by 29 publications

References 72 publications

Anticancer and Antioxidant Activity of Water-Soluble Polysaccharides from Ganoderma aff. australe against Human Osteosarcoma Cells

Anticancer and Antioxidant Activity of Water-Soluble Polysaccharides from Ganoderma aff. australe against Human Osteosarcoma Cells

Structural features and in vitro antitumor activity of a water-extracted polysaccharide from Ganoderma applanatum

Enhancement of physicochemical properties, antioxidant, antitumor, and anticoagulant activities via acetylation of Hypsizygus ulmarius polysaccharide

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