Structural features and <i>in vitro</i> antitumor activity of a water-extracted polysaccharide from <i>Ganoderma applanatum</i>

Gong, Zan; Liu, Meng; Hui, Liu; Deng, Zhiwei; Qin, Xiangxiang; Nie, Jing; Qiao, Zhe; Zhu, Huan; Zhong, Shian

doi:10.1039/d3nj01903a

New J. Chem.

2023

DOI: 10.1039/d3nj01903a

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Structural features and in vitro antitumor activity of a water-extracted polysaccharide from Ganoderma applanatum

Zan Gong

Meng Liu

Liu Hui

et al.

Abstract: The structure of GAP-2 was comprehensively analyzed, and its in vitro antitumor activity was preliminarily evaluated.

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Cited by 3 publications

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Exploring the health benefits of Ganoderma : bioactive compounds and mechanisms of action; immunomodulatory, and anti-tumour activities

Karunarathna,

Ediriweera,

Prasannath

et al. 2024

New Zealand Journal of Botany

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Exploring the health benefits of Ganoderma : bioactive compounds and mechanisms of action; immunomodulatory, and anti-tumour activities

Karunarathna,

Ediriweera,

Prasannath

et al. 2024

New Zealand Journal of Botany

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In-Vitro Antibacterial Activity of some Ganoderma Species: A Review

Arora

2023

Qeios

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The rising significance of personal health and wellbeing has spurred scientific interest in natural research on products. Numerous phytochemicals that are found naturally in plants, fruits, and vegetables have been discovered to have biological activity and are frequently hailed as being good for human health. In addition to current treatment approaches, herbal medications may be a safe and effective way to treat infectious infections. _Ganoderma_ has long been used for the management of incessant infectious conditions such diabetic foot ulcers, pneumonia, and chronic hepatitis. While there is little information on _Ganoderma's_ antiviral and antibacterial properties in humans, preliminary (_in vitro_ and _in vivo_) research show that the plant possesses a wide range of these properties. Furthermore, gram-positive and gram-negative bacteria are inhibited _in vitro_ by antibacterial components found in _Ganoderma_ species. The outcomes of preclinical (_in vitro_) and clinical investigations on the antibacterial and antifungal properties of _Ganoderma_ species are brought to light in this review.

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Alleviating Effect of Lipid Phytochemicals in Seed Oil (Brassica napus L.) on Oxidative Stress Injury Induced by H2O2 in HepG2 Cells via Keap1/Nrf2/ARE Signaling Pathway

Peng,

Liao,

Deng

et al. 2024

Nutrients

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α-tocopherol (α-T), β-sitosterol (β-S), canolol (CA), and sinapic acid (SA) are the four main endogenous lipid phytochemicals (LP) found in Brassica napus L. seed oil, which possess the bioactivity to prevent the risk of several chronic diseases via antioxidant-associated mechanisms. Discovering the enhancer effects or synergies between LP is valuable for resisting oxidative stress and improving health benefits. The objectives of this study were to identify a potentially efficacious LP combination by central composite design (CCD) and cellular antioxidant activity (CAA) and to investigate its protective effect and potential mechanisms against H2O2-induced oxidative damage in HepG2 cells. Our results indicated that the optimal concentration of LP combination was α-T 10 μM, β-S 20 μM, SA 125 μM, and CA 125 μM, respectively, and its CAA value at the optimal condition was 10.782 μmol QE/100 g. At this concentration, LP combination exerted a greater amelioration effect on H2O2-induced HepG2 cell injury than either antioxidant (tea polyphenols or magnolol) alone. LP combination could reduce the cell apoptosis rate induced by H2O2, lowered to 10.06%, and could alleviate the degree of oxidative damage to cells (ROS↓), lipids (MDA↓), proteins (PC↓), and DNA (8-OHdG↓). Additionally, LP combination enhanced the antioxidant enzyme activities (SOD, CAT, GPX, and HO-1), as well as the T-AOC, and increased the GSH level in HepG2 cells. Furthermore, LP combination markedly upregulated the expression of Nrf2 and its associated antioxidant proteins. It also increased the expression levels of Nrf2 downstream antioxidant target gene (HO-1, SOD-1, MnSOD, CAT, GPX-1, and GPX-4) and downregulated the mRNA expression levels of Keap1. The oxidative-stress-induced formation of the Keap1/Nrf2 complex in the cytoplasm was significantly blocked by LP treatment. These results indicate that LP combination protected HepG2 cells from oxidative stress through a mechanism involving the activation of the Keap1/Nrf2/ARE signaling pathways.

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Structural features and in vitro antitumor activity of a water-extracted polysaccharide from Ganoderma applanatum

Abstract: The structure of GAP-2 was comprehensively analyzed, and its in vitro antitumor activity was preliminarily evaluated.

Cited by 3 publications

References 57 publications

Exploring the health benefits of Ganoderma : bioactive compounds and mechanisms of action; immunomodulatory, and anti-tumour activities

Exploring the health benefits of Ganoderma : bioactive compounds and mechanisms of action; immunomodulatory, and anti-tumour activities

In-Vitro Antibacterial Activity of some Ganoderma Species: A Review

Alleviating Effect of Lipid Phytochemicals in Seed Oil (Brassica napus L.) on Oxidative Stress Injury Induced by H2O2 in HepG2 Cells via Keap1/Nrf2/ARE Signaling Pathway

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