Bioactive Phenolic Compounds from the Egyptian Red Sea Seagrass Thalassodendron ciliatum

Hamdy, Abdel-Hamid A.; Mettwally, Walaa S. A.; Fotouh, Mohamed Abou El; Rodrı́guez, Benjamı́n; El‐Dewany, Ahmed I.; El‐Toumy, Sayed A.; Hussein, Ahmed A.

doi:10.1515/znc-2012-5-608

Cited by 30 publications

(26 citation statements)

References 43 publications

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“…Gavagnin et al [17] reported that syphonoside from H. stipulacea inhibited apoptosis in some of the cell lines investigated. Moreover, crude extracts of the seagrass Thalassodendron ciliatum exhibited cytotoxic activity against HCT116 cells with an IC 50 of 4.2 µg/mL [18]. However, as extracts of the seagrass Halophila stipulacea had a similar activity on a non-carcinogenic cell line and did not show activity on spheroids from the 3D cell culture, they are not regarded as interesting material for future works on anticancer activities.…”

Section: Discussionmentioning

confidence: 99%

The Marine Seagrass Halophila stipulacea as a Source of Bioactive Metabolites against Obesity and Biofouling

et al. 2020

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Marine organisms, including seagrasses, are important sources of biologically active molecules for the treatment of human diseases. In this study, organic extracts of the marine seagrass Halophila stipulacea obtained by different polarities from leaves (L) and stems (S) (hexane [HL, HS], ethyl acetate [EL, ES], and methanol [ML, MS]) were tested for different bioactivities. The screening comprehended the cytotoxicity activity against cancer cell lines grown as a monolayer culture or as multicellular spheroids (cancer), glucose uptake in cells (diabetes), reduction of lipid content in fatty acid-overloaded liver cells (steatosis), and lipid-reducing activity in zebrafish larvae (obesity), as well as the antifouling activity against marine bacteria (microfouling) and mussel larval settlement (macrofouling). HL, EL, HS, and ES extracts showed statistically significant cytotoxicity against cancer cell lines. The extracts did not have any significant effect on glucose uptake and on the reduction of lipids in liver cells. The EL and ML extracts reduced neutral lipid contents on the larvae of zebrafish with EC50 values of 2.2 µg/mL for EL and 1.2 µg/mL for ML. For the antifouling activity, the HS and ML extracts showed a significant inhibitory effect (p < 0.05) against the settlement of Mytilus galloprovincialis plantigrade larvae. The metabolite profiling using HR-LC-MS/MS and GNPS (The Global Natural Product Social Molecular Networking) analyses identified a variety of known primary and secondary metabolites in the extracts, along with some unreported molecules. Various compounds were detected with known activities on cancer (polyphenols: Luteolin, apeginin, matairesinol), on metabolic diseases (polyphenols: cirsimarin, spiraeoside, 2,4-dihydroxyheptadec-16-ynyl acetate; amino acids: N-acetyl-L-tyrosine), or on antifouling (fatty acids: 13-decosenamide; cinnamic acids: 3-hydroxy-4-methoxycinnamic acid, alpha-cyano-4-hydroxycinnamic), which could be, in part, responsible for the observed bioactivities. In summary, this study revealed that Halophila stipulacea is a rich source of metabolites with promising activities against obesity and biofouling and suggests that this seagrass could be useful for drug discovery in the future.

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Section: Discussionmentioning

confidence: 99%

The Marine Seagrass Halophila stipulacea as a Source of Bioactive Metabolites against Obesity and Biofouling

et al. 2020

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“…Thalassodendrone reduced cytopathogenicy with an IC 50 of 1.96 µg/mL [124]. The phenolic compounds asebotin (2 ,4,6 -trihydroxy-4methoxydihydrochalcone 2 -O-β-d-glucopyranoside), quercetin-3-O-β-d-xylopyranoside and trans-caffeic acid ( Figure 3C) isolated from the same seagrass showed viral activity percentage reduction (96%, 70%, and 53% respectively) by plaque formation assay against HSV-1 at 2 mM [125]. Hawas et al [126] isolated Thalassiolin D (diosmetin 7-O-β-glucoside-2"-sulphate) ( Figure 3C), a flavone O-glucoside sulphate, from the seagrass Thalassia hemprichii.…”

Section: Seagrassesmentioning

confidence: 89%

“…Three isolated khayanolides, named Thaixylomolins I, K, and M, exhibited anti-H1N1 activities, with IC 50 values of 77.1, 113.5, and 121.5 µM, respectively [128]. Even if a huge number of secondary metabolites have been extracted from mangroves [119,122,125], only a small number of studies reported antiviral compounds ( Table 5).…”

Section: Mangrovesmentioning

confidence: 99%

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

et al. 2020

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Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.

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“…Along with rosmarinic acid, caffeic acid and chlorogenic acid found to be present in some trace amounts, since caffeic acid acts as a precursor for roamarinic acid in the shikimic acid biosynthesis. It was also been reported that the predominance of caffeic acid was accumulated in the leaves of P. oceanica [104] and Thalassodendron ciliatum [105]. Jeyapragash et al [51] from Halodule pinifolia, which includes caffeic acid, coumaric acid, chlorogenic acid and rosmarinic acid which found predominant than other compounds.…”

Section: Seagrasses-a Source For Marine Based Drug Discoverymentioning

confidence: 94%

Seagrass Metabolomics: A New Insight towards Marine Based Drug Discovery

Danaraj¹,

Saravanakumar²,

Mariasingarayan³

2021

Metabolomics - Methodology and Applications in Medical Sciences and Life Sciences

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Metabolomics is one of the new field of “Omics” approach and the youngest triad of system biology, which provides a broad prospective of how metabolic networks are controlled and indeed emerged as a complementary tool to functional genomics with well-established technologies for genomics, transcriptomics and proteomics. Though, metabolite profiling has been carried out for decades, owing to decisive mechanism of a molecule regulation, the importance of some metabolites in human regimen and their use as diagnostic markers is now being recognized. Plant metabolomics therefore aims to highlight the characterization of metabolite pool of a plant tissue in response to its environment. Seagrassses, a paraphyletic group of marine hydrophilous angiosperms which evolved three to four times from land plants back to the sea. Seagrasses share a number of analogous acquired metabolic adaptations owing to their convergent evolution, but their secondary metabolism varied among the four families that can be considered as true seagrasses. From a chemotaxonomic point of view, numerous specialized metabolites have often been studied in seagrasses. Hence, this chapter focus the metabolome of seagrasses in order to explore their bioactive properties and the recent advancements adopted in analytical technology platforms to study the non-targeted metabolomics of seagrasses using OMICS approach.

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Bioactive Phenolic Compounds from the Egyptian Red Sea Seagrass Thalassodendron ciliatum

Cited by 30 publications

References 43 publications

The Marine Seagrass Halophila stipulacea as a Source of Bioactive Metabolites against Obesity and Biofouling

The Marine Seagrass Halophila stipulacea as a Source of Bioactive Metabolites against Obesity and Biofouling

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

Seagrass Metabolomics: A New Insight towards Marine Based Drug Discovery

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