Bioactive Peptides and Its Alternative Processes: A Review

Abd-Talib, Norfahana; Yaji, Emmy Liza Anak; Wahab, Nur Suraya Abd; Razali, Nadia; Roslan, Jumardi; Saari, Nazamid; Pa’ee, Khairul Faizal

doi:10.1007/s12257-021-0160-8

Cited by 12 publications

(4 citation statements)

References 316 publications

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“…Although food-derived BPs have significant bioactivity, their production at the industrial scale has been hampered by several challenges, such as the sustainability of resources for mass production, the low bioavailability and yield of the peptides, and the poor sensory performance of the peptides due to their bitterness [67]. The bitter-tasting hydrophobic peptides affect the sensory quality of the resulting products and limit their use in the food and pharmaceutical industries [68].…”

Section: In Silico Analysis Of Peptides Released From Bovine Milk Fer...mentioning

confidence: 99%

An Integrated Comprehensive Peptidomics and In Silico Analysis of Bioactive Peptide-Rich Milk Fermented by Three Autochthonous Cocci Strains

Banić,

Butorac,

Čuljak

et al. 2024

IJMS

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Bioactive peptides (BPs) are molecules of paramount importance with great potential for the development of functional foods, nutraceuticals or therapeutics for the prevention or treatment of various diseases. A functional BP-rich dairy product was produced by lyophilisation of bovine milk fermented by the autochthonous strains Lactococcus lactis subsp. lactis ZGBP5-51, Enterococcus faecium ZGBP5-52 and Enterococcus faecalis ZGBP5-53 isolated from the same artisanal fresh cheese. The efficiency of the proteolytic system of the implemented strains in the production of BPs was confirmed by a combined high-throughput mass spectrometry (MS)-based peptidome profiling and an in silico approach. First, peptides released by microbial fermentation were identified via a non-targeted peptide analysis (NTA) comprising reversed-phase nano-liquid chromatography (RP nano-LC) coupled with matrix-assisted laser desorption/ionisation-time-of-flight/time-of-flight (MALDI-TOF/TOF) MS, and then quantified by targeted peptide analysis (TA) involving RP ultrahigh-performance LC (RP-UHPLC) coupled with triple-quadrupole MS (QQQ-MS). A combined database and literature search revealed that 10 of the 25 peptides identified in this work have bioactive properties described in the literature. Finally, by combining the output of MS-based peptidome profiling with in silico bioactivity prediction tools, three peptides (75QFLPYPYYAKPA86, 40VAPFPEVFGK49, 117ARHPHPHLSF126), whose bioactive properties have not been previously reported in the literature, were identified as potential BP candidates.

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Section: In Silico Analysis Of Peptides Released From Bovine Milk Fer...mentioning

confidence: 99%

An Integrated Comprehensive Peptidomics and In Silico Analysis of Bioactive Peptide-Rich Milk Fermented by Three Autochthonous Cocci Strains

Banić,

Butorac,

Čuljak

et al. 2024

IJMS

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“…The aromatic ring guarantees that the loss of electrons will not transform the peptide into free radicals. The extra electrons can deactivate the free radicals [ 157 ]. The hydrophobic properties permit the accessible entrance of the antioxidant peptides into target organs through hydrophobic interactions with membrane lipid bilayers [ 158 ].…”

Section: Biopeptides’ Potential In Cosmeceutical Applicationsmentioning

confidence: 99%

Food Peptides for the Nutricosmetic Industry

Dini

Mancusi

2023

Antioxidants

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In recent years, numerous reports have described bioactive peptides (biopeptides)/hydrolysates produced from various food sources. Biopeptides are considered interesting for industrial application since they show numerous functional properties (e.g., anti-aging, antioxidant, anti-inflammatory, and antimicrobial properties) and technological properties (e.g., solubility, emulsifying, and foaming). Moreover, they have fewer side effects than synthetic drugs. Nevertheless, some challenges must be overcome before their administration via the oral route. The gastric, pancreatic, and small intestinal enzymes and acidic stomach conditions can affect their bioavailability and the levels that can reach the site of action. Some delivery systems have been studied to avoid these problems (e.g., microemulsions, liposomes, solid lipid particles). This paper summarizes the results of studies conducted on biopeptides isolated from plants, marine organisms, animals, and biowaste by-products, discusses their potential application in the nutricosmetic industry, and considers potential delivery systems that could maintain their bioactivity. Our results show that food peptides are environmentally sustainable products that can be used as antioxidant, antimicrobial, anti-aging, and anti-inflammatory agents in nutricosmetic formulations. Biopeptide production from biowaste requires expertise in analytical procedures and good manufacturing practice. It is hoped that new analytical procedures can be developed to simplify large-scale production and that the authorities adopt and regulate use of appropriate testing standards to guarantee the population’s safety.

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“…The molecular weights of peptides are generally less than 6000 Da. Peptides are beneficial to living organisms and exhibit various biological functions [2]. Currently, peptides are of great interest in the medical field [3] and the cosmetics industry because of certain desirable properties, such as high efficacy, great specificity, and safe nature.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of core‐shell material rich in carboxyl groups and its application in the selective adsorption of cationic peptides

Ahmed

Yang

et al. 2023

J of Separation Science

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The ability to extract peptides and proteins from biological samples with excellent reusability, high adsorption capacity, and great selectivity is essential in scientific research and medical applications. Inspired by the advantages of coreshell materials, we fabricated a core-shell material using amino-functionalized silica as the core. Benzene-1,3,5-tricarbaldehyde and 3,5-diaminobenzoic acid were used as model organic ligands to construct a shell coating by alternately reacting the two monomers on the surface of silica microspheres. The resultant material featured an outstanding capability for the adsorption of cationic peptides, most likely owing to its porous structure, a large number of carboxylic functional groups, and low mass-transfer resistance. The maximum saturated adsorption capacity reached 833.3 mg/g and the adsorption process took only 20 min. Under optimized adsorption conditions, the core-shell material was used to selectively adsorb cationic peptides from the tryptic digestive solution of lysozyme and bovine serum albumin, Specifically, the analysis results showed seven cationic peptides in the eluate and twenty anionic peptides in the supernatant, which indicates the efficient trap of most cationic peptides in the digestive solution.

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Bioactive Peptides and Its Alternative Processes: A Review

Cited by 12 publications

References 316 publications

An Integrated Comprehensive Peptidomics and In Silico Analysis of Bioactive Peptide-Rich Milk Fermented by Three Autochthonous Cocci Strains

An Integrated Comprehensive Peptidomics and In Silico Analysis of Bioactive Peptide-Rich Milk Fermented by Three Autochthonous Cocci Strains

Food Peptides for the Nutricosmetic Industry

Synthesis of core‐shell material rich in carboxyl groups and its application in the selective adsorption of cationic peptides

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