Bioactive Mushroom Polysaccharides: A Review on Monosaccharide Composition, Biosynthesis and Regulation

Wang, Qiong; Wang, Feng; Xu, Zhenghong; Ding, Zhongyang

doi:10.3390/molecules22060955

Cited by 139 publications

(83 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A mixture of G. lucidum polysaccharides (known as GLP) is the main bioactive component in water-soluble extracts of the mushroom, and there is some evidence that GLP possesses potential anticancer activity (Sohretoglu & Huang, 2018). These metabolites influence the patient's innate and adaptive immune system, resulting in therapeutic immune modification (Berovič & Podgornik, 2015;Wang et al, 2017;Sudheer et al, 2018). Other metabolites found in extracts of Ganoderma have been found to be stimulators of neural stem cell proliferation in vitro and could be valuable treatments for neurodegenerative diseases (Yan et al, 2015).…”

Section: Relevance To Commercially Cultivated Fungimentioning

confidence: 99%

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Loftus¹,

Sánchez²,

Moore³

et al. 2020

Mexjbiotechnol

View full text Add to dashboard Cite

We review the most recent developments in understanding the nature of development and morphogenesis in fungi and suggest how it might be applied to biotechnological manipulation of some cultivated mushrooms. We believe that it is essential to match the deductions of the molecular observations of the genomics generation with the inductive reasoning of the in vivo experiments and observations of the pregenomics generations to take full advantage of the synergism between the approaches to illuminate better the living biology of the system. As specific examples we show how model mushroom fungi (Coprinopsis and Volvariella) make hymenia and gills (not forgetting how the polypore Phellinus makes tubes), developmental commitment and pattern formation. The Coprinopsis sporophore also provides examples for the construction of mushroom stems and the coordination of cell behaviour throughout the maturing sporophore and the timing process that achieves that. This leads us to consider the mechanics of the mushroom and its dependence on the biochemistry and regulation of metabolism in relation to morphogenesis, and how it varies between species. We finish with our summary of the basic principles of fungal developmental biology. Having demonstrated how classic approaches allowed progress to be made in the study of fungal development we show how this has been accelerated by genomics and other aspects of global analysis of macromolecules. We also include work on some cultivated mushrooms to illustrate how the generalisations from research on model organisms might be applied in mushroom farming.

show abstract

Section: Relevance To Commercially Cultivated Fungimentioning

confidence: 99%

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Loftus¹,

Sánchez²,

Moore³

et al. 2020

Mexjbiotechnol

View full text Add to dashboard Cite

show abstract

“…Polysaccharides (PSs) are important and bioactive components of F. filiformis and other edible and medicinal mushrooms [47]. Glucans, such as lentinan, ganoderan, grifolan, and schizophyllan are well-studied PSs that can be produced by different fungi [48]. Previous studies have shown that F. velutipes polysaccharides (FVPs) have good immunomodulatory and anti-proliferation activities and improve learning and memory impairment in rats [4,5].…”

Section: Genes Involved In Polysaccharide Biosynthesis In F Filiformismentioning

confidence: 99%

Genome-wide analysis and prediction of genes involved in the biosynthesis of polysaccharides and bioactive secondary metabolites in high-temperature-tolerant of wild Flammulina filiformis

Chen

Tang

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Flammulina filiformis (=Asian “F.velutipes”) is a popular commercial edible mushroom. Many bioactive compounds with medicinal effects, such as polysaccharides and sesquiterpenoids, have been isolated and identified from F. filiformis, but their biosynthesis and regulation at the molecular level remains unclear. In this study, we sequenced the genome of the wild strain F. filiformis Liu355, predicated its the biosynthetic gene clusters (BGCs) and profiled the expression of these genes in wild and cultivar strains and in different developmental stages of the wild F. filiformis strain by a comparative transcriptomic analysis. Results: We found that the genome of the F. filiformis was 35.01 M bp in length and harbored 10396 gene models. Thirteen putative terpenoid gene clusters were predicted and 12 sesquiterpene synthase genes belonging to four different groups and two type I polyketide synthase gene clusters were identified in the F. filiformis genome. The number of genes related to terpenoid biosynthesis was higher in the wild strain (119 genes) than in the cultivar strain (81 genes). Most terpenoid biosynthesis genes were upregulated in the primordium and fruiting body of the wild strain, while the polyketide synthase genes were generally upregulated in the mycelium of the wild strain. Moreover, genes encoding UDP-glucose pyrophosphorylase and UDP-glucose dehydrogenase, which are involved in polysaccharide biosynthesis, had relatively high transcript levels both in the mycelium and fruiting body of the wild F. filiformis strain. Conclusions: F. filiformis is enriched in a number of gene clusters involved in the biosynthesis of polysaccharides and terpenoid bioactive compounds and these genes usually display differential expression between wild and cultivar strains, even in different developmental stages. This study expands our knowledge of the biology of F. filiformis and provides valuable data for elucidating the regulation of secondary metabolites in this unique F. filiformis strain.

show abstract

“…Using intracellular nucleotide sugars as substrate, the EPS are synthesized in the cell membrane through the action of a large number of enzymes. Detailed information on the role of some of these enzymes such as the α-phosphoglucomutase is summarized in the review of Wang et al [12], who especially focused on EPS biosynthesis pathways, and on prospects for controlling biosynthesis of EPS with enhanced bioactivity. Supposed biological functions of the extracellular polymeric substances comprise supporting matrix adhesion, immobilizing extracellular enzymes, counteracting dehydration of the hyphae, storing excess nutrients, and contributing to lignin degradation [13,14].…”

Section: Submerged Cultivation Of Basidiomycotamentioning

confidence: 99%

Exopolysaccharides from Basidiomycota: Formation, isolation and techno‐functional properties

Jaros

Köbsch

Rohm

2018

Engineering in Life Sciences

View full text Add to dashboard Cite

This Mini Review gives an overview of and respective references for the production and properties of exopolysaccharides from Basidiomycota in submerged cultivation. Media and conditions that are usually applied in laboratory culture are summarized, and the lack of studies related to up‐scaling is addressed. Procedures for isolation and purification of the exopolysaccharides from the fermentation media are reviewed, and challenges related to exopolysaccharide quantification are discussed. Finally, the techno‐functional properties of the respective exopolysaccharides, and potential applications in foods are addressed.

show abstract

Bioactive Mushroom Polysaccharides: A Review on Monosaccharide Composition, Biosynthesis and Regulation

Cited by 139 publications

References 85 publications

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Genome-wide analysis and prediction of genes involved in the biosynthesis of polysaccharides and bioactive secondary metabolites in high-temperature-tolerant of wild Flammulina filiformis

Exopolysaccharides from Basidiomycota: Formation, isolation and techno‐functional properties

Contact Info

Product

Resources

About