Bioactive mixed-ligand zinc(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridine derivatives

Cytotoxic mixed-ligand copper(ii) complexes with 1H-tetrazole-5-acetic acid and oligopyridine derivatives

“…Thus, complex 2 showed selectivity for HepG-2 and MCF-7 cell lines despite its high cytotoxicity. The complex with phendione in a similar series of zinc complexes 29 also showed selectivity to breast carcinoma cells.…”

“…The antimicrobial activity of olygopyridines and H 2 L has been previously studied and presented in. 29,32,39 All studied compounds do not have fungistatic activity against P.italicum . The results of the antibacterial activity study showed that all compounds are equally active against St .…”

“…Previously, a series of zinc( ii ) complexes with H 2 L and oligopyridine derivatives was obtained. 29 In this work, we replaced zinc( ii ) ion with copper( ii ) to study the effect of the metal ion on cytotoxic and antimicrobial activity.…”

“…Interestingly, the obtained pattern of changes in the antimicrobial activity (dependence on oligopyridine used) of mixed-ligand zinc( ii ) complexes with H 2 L and oligopyridines is not observed for copper complexes. 29 Structure related zinc( ii ) complexes didn’t show fungistatic activity, as did copper( ii ) complounds. The protistocidal and antibacterial activities of zinc( ii ) complexes depend on oligopyridine and vary in the following order: phendione > dmphen, phen, dmbipy > bipy.…”

“…Interestingly, the obtained pattern of changes in the antimicrobial activity (dependence on oligopyridine used) of mixedligand zinc(II) complexes with H 2 L and oligopyridines is not observed for copper complexes. 29 Structure related zinc(II) C 5 = 300 mM, C 6 = 60 mM). Stock solutions were prepared by dissolving complexes in DMSO (1, 2, 5, 6) or EtOH (3,4), then the solutions were diluted with water.…”