Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium

Debbab, Abdessamad; Aly, Amal H.; Edrada-Ebel, RuAngelie; Wray, Victor; Müller, Wernér E.G.; Totzke, Frank; Zirrgiebel, Ute; Schächtele, Christoph; Kubbutat, Michael H.G.; Lin, Wen Han; Mosaddak, M.; Hakiki, A.; Proksch, Peter; Ebel, Rainer

doi:10.1021/np8004997

Cited by 145 publications

(76 citation statements)

References 50 publications

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“…Eight compounds were isolated from this fungal strain, including two alterporriol-type dimers, the relative and absolute configurations of which were established by using spectral and theoretical methods. The novel compound, alterporriol S ( 1 ), was the first member of alterporriols with a unique C-10−C-2′ linkage [20,22,23,26,27,28,29,30,31,32,33]. Anthranoid dimers consisting of such a coupling type could only be found in a small population of terrestrial plants [14,15,34,35,36,37,38,39,40,41,42,43] and marine animal [44]; this was the first report of a fungus origin.…”

Section: Discussionmentioning

confidence: 99%

Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions

Xia

et al. 2014

Marine Drugs

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A new alterporriol-type anthranoid dimer, alterporriol S (1), along with seven known anthraquinone derivatives, (+)-aS-alterporriol C (2), hydroxybostrycin (3), halorosellinia A (4), tetrahydrobostrycin (5), 9α-hydroxydihydrodesoxybostrycin (6), austrocortinin (7) and 6-methylquinizarin (8), were isolated from the culture broth of the mangrove fungus, Alternaria sp. (SK11), from the South China Sea. Their structures and the relative configurations were elucidated using comprehensive spectroscopic methods, including 1D and 2D NMR spectra. The absolute configurations of 1 and the axial configuration of 2 were defined by experimental and theoretical ECD spectroscopy. 1 was identified as the first member of alterporriols consisting of a unique C-10−C-2′ linkage. Atropisomer 2 exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 value 8.70 μM.

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Section: Discussionmentioning

confidence: 99%

Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions

Xia

et al. 2014

Marine Drugs

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“…Isolation of endophytic fungus was done by using a method described by Debbab et al [15]. The rhizome was rinsed in sterilized water.…”

Section: Methodsmentioning

confidence: 99%

SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI Chochlibus lunatus OF THE RHIZOME OF TUNJUK LANGIT (Helmynthostachys zaylanica)

Fitrya¹,

Muharni²

2013

Indones. J. Chem.

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“…Endophytic fungi are a very diverse polyphyletic group of microorganisms; they can thrive asymptomatically in the tissues of plants aboveground as well as belowground, including stems, leaves and/or roots [26]. Many endophytes have the potential to synthesize various bioactive metabolites that may directly or indirectly be used as therapeutic agents against numerous diseases [3,19,21,[27][28][29]. Occasionally and usually hiting major buck, endophytes that produce host plant secondary metabolites with therapeutic value or potentials have been discovered; some examples include paciltaxel (also known as taxol) [9] and podophyllotoxin [17,30].…”

Section: Endophytic Fungi and Search For Active Metabolitesmentioning

confidence: 99%

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

Omeje¹,

Ahomafor²,

Onyekaba³

et al. 2017

Natural Products and Cancer Drug Discovery

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In comparison with other natural sources like plants, highly diverse microorganisms are narrowly explored, especially with respect to their limitless potentials as repositories of exceptionally bioactive natural products. Of these organisms, fungi inhabiting tissues of plant in a noninvasive relationship (endophytic fungi) have proven undeniably useful and unmatchable as sources of potent bioactive molecules against several diseases such as cancer and related ailments. In general terms, endophytic fungi are highly prevalent organisms found in the tissue (intracellular or intercellular) of plants and at least for reasonable portion of their lives. It has been proven that virtually every plant, irrespective of habitat and climate, plays host to wide varieties of endophytes. Endophytic fungi produce metabolites produced by diferent biosynthetic pathways to that of the host plant, and this robustness equips them to synthesize unlimited structural entities and scafolds of diverse classes. Interestingly too, the cohabitation/culture of these fungi with certain bacteria ofers even stronger hopes for anticancer drug discovery. The endless need for potent drugs has necessitated the search of bioactive molecules from several sources, and endophytic fungi appear to be a recipe. This chapter is an atempt to present the current trend of research with these very promising organisms.

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Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium

Cited by 145 publications

References 50 publications

Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions

Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions

SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI <i>Chochlibus lunatus</i> OF THE RHIZOME OF TUNJUK LANGIT (<i>Helmynthostachys zaylanica</i>)

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

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