Bioactive materials for in vivo sweat gland regeneration

Yang, Xinling; Xiong, Mingchen; Fu, Xiaobing; Sun, Xiaoyan

doi:10.1016/j.bioactmat.2023.07.025

Cited by 3 publications

(1 citation statement)

References 215 publications

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“…Burn injuries are devastating, affecting approximately 11 million people each year. , Besides the urgent need to quickly close wounds and help patients survive extensive burns, the reconstruction of skin appendages, such as sweat glands, is also important for the functional recovery of burn patients. − Recent studies have emphasized the significance of cutaneous nerves in maintaining skin physiology and supporting appendages. , Without proper innervation, wound healing can be compromised, leading to poor outcomes . Current burn treatments, such as autografts, allografts, artificial skin grafts, and cell-based replacement therapies, mainly focus on introducing external substances to expedite wound coverage but are insufficient to regenerate a physiological-like niche infiltrated by nerves and vascular network .…”

Section: Introductionmentioning

confidence: 99%

Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

Pi,

Chen,

Liu

et al. 2024

ACS Nano

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Remodeling the endogenous regenerative microenvironment in wounds is crucial for achieving scarless, functional tissue regeneration, especially the functional recovery of skin appendages such as sweat glands in burn patients. However, current approaches mostly rely on the use of exogenous materials or chemicals to stimulate cell proliferation and migration, while the remodeling of a pro-regenerative microenvironment remains challenging. Herein, we developed a flexible sono−piezo patch (fSPP) that aims to create an endogenous regenerative microenvironment to promote the repair of sweat glands in burn wounds. This patch, composed of multifunctional fibers with embedded piezoelectric nanoparticles, utilized low-intensity pulsed ultrasound (LIPUS) to activate electrical stimulation of the target tissue, resulting in enhanced pro-regenerative behaviors of niche tissues and cells, including peripheral nerves, fibroblasts, and vasculatures. We further demonstrated the effective wound healing and regeneration of functional sweat glands in burn injuries solely through such physical stimulation. This noninvasive and drug-free therapeutic approach holds significant potential for the clinical treatment of burn injuries.

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Section: Introductionmentioning

confidence: 99%

Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

Pi,

Chen,

Liu

et al. 2024

ACS Nano

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Collagen-based nanofibers: revolutionizing therapeutics for impaired wound healing

Sabarees,

Vishvaja,

Raghuraman

et al. 2024

International Journal of Polymeric Materials and Polymeric Biom

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The application of ultrasound for skin and appendage regeneration: A comprehensive review

Yu,

Li,

Huang

2024

TIL

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<p>Ultrasound, an exogenous physical stimulus, has important application prospects in the field of regenerative medicine, especially in skin regeneration, due to its safety, controllability, and deep penetration depth. This review examines the potential of ultrasound therapy in promoting skin regeneration by exploring its effects on skin cells, mechanisms of action in regeneration, and responsive materials. With its deep tissue penetration and excellent biocompatibility, ultrasound presents an attractive option for enhancing wound healing and skin regeneration. By discussing current challenges and future prospects, this review offers insights to guide the development of innovative ultrasound-based approaches for clinical wound treatment.</p>

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Bioactive materials for in vivo sweat gland regeneration

Cited by 3 publications

References 215 publications

Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

Collagen-based nanofibers: revolutionizing therapeutics for impaired wound healing

The application of ultrasound for skin and appendage regeneration: A comprehensive review

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