Bioactive Materials Based on Hydroxypropyl Methylcellulose and Silver Nanoparticles: Structural-Morphological Characterization and Antimicrobial Testing

Abstract

The progress achieved in recent years in the biomedical field justifies the objective evaluation of new techniques and materials obtained by using silver in different forms as metallic silver, silver salts, and nanoparticles. Thus, the antibacterial, antiviral, antifungal, antioxidant, and anti-inflammatory activity of silver nanoparticles (AgNPs) confers to newly obtained materials characteristics that make them ideal candidates in a wide spectrum of applications. In the present study, the use of hydroxypropyl methyl cellulose (HPMC) in the new formulation, by embedding AgNPs with antibacterial activity, using poly(N-vinylpyrrolidone) (PVP) as a stabilizing agent was investigated. AgNPs were incorporated in HPMC solutions, by thermal reduction of silver ions to silver nanoparticles, using PVP as a stabilizer; a technique that ensures the efficiency and selectivity of the obtained materials. The rheological properties, morphology, in vitro antimicrobial activity, and stability/catching of Ag nanoparticles in resulting HPMC/PVP-AgNPs materials were evaluated. The obtained rheological parameters highlight the multifunctional roles of PVP, focusing on the stabilizing effect of new formulations but also the optimization of some properties of the studied materials. The silver amount was quantified using the spectroscopy techniques (energy-dispersive X-ray fluorescence (XRF), energy-dispersive X-ray spectroscopy (EDX)), while formation of the AgNPs was confirmed using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Also, the morphological examination (Atomic Force Microscopy (AFM) and Scanning electron microscopy (SEM)) by means of the texture roughness parameters has evidenced favorable characteristics for targeted applications. Antibacterial activity was tested against Escherichia coli and Staphylococcus aureus and was found to be substantially improved was silver was added in the studied systems.

Bioactive Polyoxymethylene Composites: Mechanical and Antibacterial Characterization

“…Increasing the content of titanium oxide from 2% to 4% by weight caused a slight increase in biocidal activity. In addition, the authors state that the size of the particles is extremely significant; the additives in the form of nanoparticles have a much larger contact surface with bacteria, which promotes the oxidation of the outer cell membrane, thus increasing the biocidal effects [ 43 , 44 ].…”

Influence of Carboxymethyl Cellulose on the Green Synthesis of Gold Nanoparticles Using Gliricidia sepium and Petiveria alliacea Extracts: Surface-Enhanced Raman Scattering Effect Evaluation

“…According to the stabilization of MNPs, fluorides, carboxylates, polymers, and acids have been reported; − however, these can modify the chemistry of the surface and the electrical, catalytic, and optical properties. Natural derivatives such as chitosan, hydroxypropylmethylcellulose, and other cellulose derivatives such as ethylcellulose , and carboxymethylcellulose , have also been used. The latter is mentioned as a reducing agent and stabilizer of MNPs , and as a matrix to form metallic films for biomedical applications. , Carboxymethyl cellulose or CMC is a linear-chain macromolecular polymer based on covalent bonds of d -glucopyranoses , due to its hydrosolubility and biocompatibility properties.…”