Bioactive Polyoxymethylene Composites: Mechanical and Antibacterial Characterization

Kaczor, Paulina; Bazan, Patrycja; Kuciel, Stanisław

doi:10.3390/ma16165718

Cited by 4 publications

(2 citation statements)

References 48 publications

(53 reference statements)

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“…The alarming worldwide spread of AMR demands the creation of novel protocols and tools aimed at preventing and controlling microorganisms and thus decreasing the need for antimicrobials. One promising avenue towards achieving this goal is the development of elastomers with antimicrobial properties [24,26,27].…”

Section: Discussionmentioning

confidence: 99%

Innovative Elastomers with Antimicrobial Activity May Decrease Infection Risks during Milking

Meroni,

Sora,

Zaghen

et al. 2023

Pathogens

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Contagious pathogens are very costly to dairy herds, and they may have zoonotic and reverse-zoonotic potentials and may contribute to the spread of antimicrobial resistance. One of the most important risk factors for spreading these infections is milking, when liner contamination may transfer the pathogens from infected to healthy cows. There is no effective protocol to prevent the transmission of infection without the segregation of infected cows. Recently, the availability of elastomers with patented antimicrobial components in their formulations has allowed the exploration of alternative methods to reduce the risk of infection. Two different types of elastomers (rubber and silicone) and nine different formulations were challenged with three major mastitis pathogens (S. aureus, S. agalactiae, and E. coli). The results that were obtained in this study were interesting and unexpected. Indeed, to our knowledge, this is the first study to show that basic rubber materials have intrinsic antimicrobial activity. Silicone elastomers did not exhibit the same levels of bactericidal activity, although they did exhibit some antibacterial capacity. A significant decrease in bacterial survival curves was observed for all the formulations tested when antimicrobial components were added. The different results observed for the various products are likely due to the different formulations and diverse manufacturing processes. The availability of these new materials that significantly reduce the bacterial load on the liner surface may reduce the risk of spreading intramammary infections during milking. This would be an important step forward in achieving global sustainability of dairy herds, consistent with the objectives of One Health, by reducing the risks of zoonotic diseases and antimicrobial treatments.

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Section: Discussionmentioning

confidence: 99%

Innovative Elastomers with Antimicrobial Activity May Decrease Infection Risks during Milking

Meroni,

Sora,

Zaghen

et al. 2023

Pathogens

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show abstract

“…In this regard, modifying IPEC by including an additional low-molecular-weight biocidal agent, for example, metal nano particles or metal oxides, is proposed. Among the metals, nano-Ag, nano-Au, nano-Cu, and nano-Se are often considered as an additive [ 27 , 28 ]. Silver and its oxide have proven themselves especially widely.…”

Section: Introductionmentioning

confidence: 99%

Ag2O-Containing Biocidal Interpolyelectrolyte Complexes on Glass Surfaces—Adhesive Properties of the Coatings

Pigareva,

Paltsev,

Marina

et al. 2023

Polymers

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Biocidal coatings are of great interest to the healthcare system. In this work, the biocidal activity of coatings based on a complex biocide containing polymer and inorganic active antibacterial components was studied. Silver oxide was distributed in a matrix of a positively charged interpolyelectrolyte complex (IPEC) of polydiallyldimethylammonium chloride (PDADMAC) and sodium polystyrene sulfonate (PSS) using ultrasonic dispersion, forming nanoparticles with an average size of 5–6 nm. The formed nanoparticles in the matrix are not subject to agglomeration and changes in morphology during storage. It was found that the inclusion of silver oxide in a positively charged IPEC allows a more than 4-fold increase in the effectiveness of the complex biocide against E. coli K12 in comparison with the biocidal effect of PDADMAC and IPEC. Polycation, IPEC, and the IPEC/Ag2O ternary complex form coatings on the glass surface due to electrostatic adsorption. Adhesive and cohesive forces in the resulting coatings were studied with micron-scale coatings using dynamometry. It was found that the stability of the coating is determined primarily by adhesive interactions. At the macro level, it is not possible to reliably identify the role of IPEC formation in adhesion. On the other hand, use of the optical tweezers method makes it possible to analyze macromolecules at the submicron scale and to evaluate the multiple increase in adhesive forces when forming a coating from IPEC compared to coatings from PDADMAC. Thus, the application of ternary IPEC/Ag2O complexes makes it possible to obtain coatings with increased antibacterial action and improved adhesive characteristics.

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Ag<sub>2</sub>O-Containing Biocidal Interpolyelectrolyte Complexes on Glass Surfaces – Adhesive Properties of the Coatings

Pigareva,

Paltsev,

Marina

et al. 2023

Preprint

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Biocidal coatings are of great interest to the healthcare system. In this work, the biocidal activity of coatings based on a complex biocide containing polymer and inorganic active antibacterial c omponents was studied. Silver oxide was distributed in a matrix of a positively charged interpolyelectrolyte complex (IPEC) of polydiallyldimethylammonium chloride (PDADMAC) and sodium polystyrene sulfonate (PSS) using ultrasonic dispersion, forming nanoparticles with an average size of 5-6 nm. The formed nanoparticles in the matrix are not subject to agglomeration and changes in morphology during storage. It was found that the inclusion of silver oxide in a positively charged IPEC allows a 4-fold increase in the effectiveness of the complex biocide against E. coli K12 in comparison with the biocidal effect of PDADMAC and IPEC. Polycation, IPEC and the IPEC/Ag2O ternary complex form coatings on the glass surface due to electrostatic adsorption. Adhesive and cohesive forces in the resulting coatings were studied on micron-scale coatings using dynamometry. It was found that the stability of the coating is determined primarily by adhesive interactions. At the macro level, it is not possible to reliably identify the role of IPEC formation on adhesion. On the other hand, the use of the optical tweezers method makes it possible to analyze macromolecules in submicron scale and to evaluate the multiple increase in adhesive forces when forming a coating from IPEC compared to coatings from PDADMAC. Thus, the application of ternary IPEC/Ag2O complexes makes it possible to obtain coatings with increased antibacterial action and improved adhesive characteristics.

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Bioactive Polyoxymethylene Composites: Mechanical and Antibacterial Characterization

Cited by 4 publications

References 48 publications

Innovative Elastomers with Antimicrobial Activity May Decrease Infection Risks during Milking

Innovative Elastomers with Antimicrobial Activity May Decrease Infection Risks during Milking

Ag2O-Containing Biocidal Interpolyelectrolyte Complexes on Glass Surfaces—Adhesive Properties of the Coatings

Ag<sub>2</sub>O-Containing Biocidal Interpolyelectrolyte Complexes on Glass Surfaces – Adhesive Properties of the Coatings

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