Bioactive lipids derived from arachidonic acid metabolism in different types of renal replacement therapy

Stępniewska, Joanna; Dołęgowska, Barbara; Puchałowicz, Kamila; Gołembiewska, Edyta; Ciechanowski, Kazimierz

doi:10.1016/j.chemphyslip.2017.05.003

Cited by 8 publications

(16 citation statements)

References 57 publications

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“…acids and the type of renal replacement therapy used [19]. In the studies described in this work, however, this relationship was found.…”

Section: Stępniewska Et Al Did Not Demonstrate a Relationship Betweementioning

confidence: 55%

“…Glomerulonephritis, cyclosporine overdose, or rejection of kidney transplants reduce renal blood flow to the kidney afferent and efferent arterioles, supplying the glomerulus, reduce mesangial cell count, increase plasminogen activator inhibitor-1 (PAI-1) activity, decrease tissue plasminogen activator (t-PA) activity, and increase TGF-β levels. This leads to the deposition of fibrin and matrix proteins in the glomeruli and mesangium, and leads to the worsening of renal failure [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Averna et al showed that the administration of drugs that reduce or eliminate thromboxane-dependent activation of platelets in vivo may reduce the risk of cardiovascular events but may also prevent the long-term survival of patients with kidney transplantation [21]. Considering that an increase in thromboxane concentration may be indicative of transplant rejection and may lead to an increase in TGF-β concentration, which is also a sign of poor functioning of the transplanted kidney [19,20], together with the results obtained in our own studies, it can be suggested that the decrease in TXB 2 and TGF-β after kidney transplantation may be a sign of good prognosis for this group of patients. The relationship between the concentration of thromboxane and TGF-β is also confirmed by correlations obtained in our own studies.…”

Section: Discussionmentioning

confidence: 99%

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The effect of renal replacement therapy on the concentration of selected arachidonic acid derivatives

Cecerska-Heryć¹,

Heryć²,

Wiśniewska³

et al. 2020

Preprint

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Background: Chronic kidney disease (CKD) is one of the most frequently occurring diseases. A side effect of dialysis is, among other things, platelet activation. Arachidonic acid (AA) derivatives are released from activated platelets. In addition to being involved in many physical processes, they are also involved in the development of inflammation, asthma, cancer, diabetes, hypertension, and the pathogenesis of kidney disease. The aim of the study was to determine the concentrations of arachidonic acid (AA) derivatives (TXB 2 ,5-HETE, 12-HETE, 15-HETE), in patients with CKD.Methods:117 patients were qualified to the study group. Based on the type of renal replacement therapy, patients are divided into the following groups: hemodialysis, peritoneal dialysis, kidney transplant patients and conservative treatment (30; 30; 27; 30 patients). The control group consisted of 30 healthy volunteers. The concentrations of TXB 2 , 5-HETE, 12-HETE, 15-HETE, in the blood serum was measured by ELISA methods.Results: It was shown that renal replacement therapy significantly influences the concentration of TXB 2 p=0,010 5-HETE p<0,001 and 15-HETE p<0,001). There was a relationship between the type of renal replacement therapy and the duration of dialysis, and the concentration of TXB 2 , 12-HETE acid, and 15-HETE (p<0,001; p<0,001;p<0,001).Conclusions: The type of renal replacement therapy used had an effect on the concentration of arachidonic acid derivatives (TXB2, 5-HETE and 15-HETE). Apart from the type of therapy used in CKD patients, the factors significantly affecting the release of arachidonic acid derivatives were the age of patients, the duration of dialysis, the cause of CKD, and the stage of its advancement.

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“…acids and the type of renal replacement therapy used [19]. In the studies described in this work, however, this relationship was found.…”

Section: Stępniewska Et Al Did Not Demonstrate a Relationship Betweementioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of renal replacement therapy on the concentration of selected arachidonic acid derivatives

Cecerska-Heryć¹,

Heryć²,

Wiśniewska³

et al. 2020

Preprint

Self Cite

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“…Free AA can be metabolized into bioactive eicosanoids, such as the tetranor 12‐HETE (Hirabayashi & Shimizu, ; Leslie, ). Tetranor 12‐HETE has proinflammatory properties, participates in the inflammatory response of cells, stimulates the proliferation of glomerular endothelial cells and accelerates the progression of hypertension and atherosclerosis in patients with chronic kidney disease (Stepniewska, Dolegowska, Puchalowicz, Golembiewska, & Ciechanowski, ). Tetranor 12‐HETE has been reported to play an important role in the process of oxidative stress‐induced apoptosis and is regarded as a specific indicator of kidney damage caused by oxidative stress (Imig, ).…”

Section: Discussionmentioning

confidence: 99%

“…Free AA can be metabolized into bioactive eicosanoids, such as the tetranor 12-HETE (Hirabayashi & Shimizu, 2000;Leslie, 1997). Tetranor 12-HETE has proinflammatory properties, participates in the inflammatory response of cells, stimulates the proliferation of glomerular endothelial cells and accelerates the progression of hypertension and atherosclerosis in patients with chronic kidney disease (Stepniewska, Dolegowska, Puchalowicz, Golembiewska, & Ciechanowski, 2017).…”

Section: Discussionmentioning

confidence: 99%

Metabonomics analysis of kidneys in rats administered with chronic low‐dose cadmium by ultra‐performance liquid chromatography‐mass spectrometry

Zhang

Jia

Liu

et al. 2018

J of Applied Toxicology

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This study aimed to investigate the nephrotoxicity in rats administered with chronic low‐dose cadmium (Cd) by ultra‐performance liquid chromatography‐mass spectrometry. A total of 40 male Sprague‐Dawley rats were randomly assigned to four groups, namely: control; low‐dose (0.13 mg/kg·body weight [bw]); middle‐dose (0.80 mg/kg·bw); and high‐dose (4.89 mg/kg·bw). The rats received CdCl2 daily via drinking water for 24 weeks. Rat kidneys were collected for metabonomics analysis. Principal components analysis and partial least‐squares discriminant analysis were used to investigate the metabonomics profile changes in the kidney samples and to screen the potential biomarkers. Ten metabolites were identified in the positive and negative ion modes. Compared with the control group, the intensities of tetranor 12‐HETE, uric acid, hypoxanthine, phenylacetylglycine, guanidinosuccinic acid and xanthosine significantly increased (P < 0.01), and those of imidazolelactic acid, lactose 6‐phosphate, l‐urobilinogen and arachidonic acid significantly decreased (P < 0.01) in the high‐dose group. Results showed that exposure to Cd in rats induced oxidative stress to the kidneys and disrupted amino acid metabolism, fatty acid metabolism and energy metabolism.

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Comprehensive analysis of the phospholipids and phytosterols in Schisandra chinensis oil by UPLC-Q/TOF- MSE

Gao

2019

Chemistry and Physics of Lipids

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Bioactive lipids derived from arachidonic acid metabolism in different types of renal replacement therapy

Cited by 8 publications

References 57 publications

The effect of renal replacement therapy on the concentration of selected arachidonic acid derivatives

The effect of renal replacement therapy on the concentration of selected arachidonic acid derivatives

Metabonomics analysis of kidneys in rats administered with chronic low‐dose cadmium by ultra‐performance liquid chromatography‐mass spectrometry

Comprehensive analysis of the phospholipids and phytosterols in Schisandra chinensis oil by UPLC-Q/TOF- MSE

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