Bioactive Glasses in Periodontal Regeneration: A Systematic Review

Abushahba, Faleh; Algahawi, Ahmed; Areid, Nagat; Hupa, Leena; Närhi, Timo

doi:10.1089/ten.tec.2023.0036

Cited by 4 publications

(2 citation statements)

References 67 publications

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“…Bioglass has demonstrated osteostimulative properties in the context of bone regeneration [16]. A systematic review by Abushahba et al affirms the effectiveness of bioglass in the treatment of osseous defects [17]. Nevertheless, this biomaterial is associated with several drawbacks, including a delayed resorption time and inferior mechanical properties.…”

Section: Discussionmentioning

confidence: 99%

Development and Characterization of Gadolinium and Copper Reinforced Bioactive Glass: An In Vitro Study

Bajpai,

Rajasekar

2024

Cureus

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Introduction: Bioactive glass, an innovative alloplastic material utilizing a matrix of silica particles combined with calcium and phosphorus, has been widely employed for the regeneration of bony defects due to its bone-forming capabilities and biocompatibility. Nevertheless, it comes with several drawbacks, including a slow degradation rate, low mechanical strength, and susceptibility to fractures. To address these issues, the present research was done to develop and characterize a novel bioactive glass incorporating gadolinium (Gd) and copper (Cu).Methods: The bioactive glass doped with Gd and Cu were synthesized and subjected to characterization through X-ray diffraction (XRD), scanning electron microscopy (SEM), and attenuated total reflectanceinfrared (ATR-IR) analysis.Results: The bioactive glass, enriched with Gd and Cu, underwent analysis using ATR-IR spectroscopy, XRD, and SEM. ATR-IR revealed characteristic silicate bands, while SEM indicated the presence of particles larger than 4 μm. XRD analysis identified the formation of Na 2 Ca 4 (PO 4 ) 2 SiO 4 (Silicorhenatite), Na 2 Ca 2 Si 3 O 9 (Combeite), and wollastonite (calcium inosilicate mineral; CaSiO 3 ). The crystalline nature of these compounds contributed to the favorable mechanical properties of the bioactive glass.Conclusion: In summary, the creation of the innovative Gd-Cu-incorporated bioactive glass demonstrates favorable mechanical characteristics, suggesting significant promise for augmenting bone regeneration.

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Section: Discussionmentioning

confidence: 99%

Development and Characterization of Gadolinium and Copper Reinforced Bioactive Glass: An In Vitro Study

Bajpai,

Rajasekar

2024

Cureus

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“…Bioglass has been proven promising with its osteoconductive and osteostimulation behavior in periodontal regeneration alone or in combination with other biomaterials [15][16][17][18][19]. Abushahba et al, in their systematic review, have concluded that bioglass is effective in treating periodontal bone defects [20]. However, the material has many disadvantages, such as delayed degradation rate, low mechanical strength, and fracture resistance.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and Characterization of an Innovative Silver- and Gadolinium-Doped Bioglass for Bone Regeneration

Korukonda,

Suresh,

2023

Cureus

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BackgroundPeriodontal regeneration aims for the three-dimensional reconstruction of bone defects, and over the years, bone grafts with or without barrier membranes have provided us with promising results. Particulate bone grafts can be classified according to the source of procurement as autografts, allografts, xenografts, and alloplasts. Bioglass, an innovative alloplast that uses silica particles as a matrix incorporated with calcium and phosphorus, has been extensively used as a propitious material for bone regeneration owing to its inherent osteogenic ability and biocompatibility but presents with various disadvantages such as slow degradation rate, low mechanical strength, and fracture resistance. A novel silver (Ag)-gadolinium (Gd)doped bioglass was fabricated to improve the mechanical properties, biocompatibility, and osteogenic ability when compared with bioglass (control). Materials and methodsThe Ag-and Gd-doped bioglass network was prepared and assessed for the morphological and structural properties by scanning electron microscopy (SEM) analysis, X-ray diffraction (XRD), and attenuated total reflectance (ATR)-infrared (IR). The cytotoxicity of Gd and Ag-doped bioglass was assessed using the MG63 cell line through the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide) assay at various concentrations and the absorbance of the solution was measured at 570 nm using a microplate reader. The osteogenic ability of the material was assessed by alkaline phosphatase activity and collagen estimation. ResultsATR-IR spectroscopy, SEM, and XRD were used to examine the bioglass network doped with Gd and Ag. ATR-IR exhibited classic silicate bands, whereas SEM indicated particles bigger than 5 μm. XRD analysis revealed the production of Na2Ca2Si3O9, Na2Ca4(PO4)2SiO4, and wollastonite. The excellent crystallinity of Na2Ca2Si3O9 provided the bioglass network with good mechanical characteristics.The Gd-Ag-bioglass did not exhibit any toxicity towards the living cells at increasing concentrations from 12.5 µg to 100 µg. The alkaline phosphatase activity was increased by 10% and the collagen estimation remained consistent with bioglass (control). ConclusionIn conclusion, the fabrication of the novel Gd-Ag-doped bioglass shows good cytocompatibility and osteogenic ability and shows great potential to enhance bone regeneration.

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Nanocrystallization as a tool for controlling in vitro dissolution of borophosphate glass

Dziewanowska,

Karczewski,

Ali

et al. 2023

Ceramics International

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Bioactive Glasses in Periodontal Regeneration: A Systematic Review

Cited by 4 publications

References 67 publications

Development and Characterization of Gadolinium and Copper Reinforced Bioactive Glass: An In Vitro Study

Development and Characterization of Gadolinium and Copper Reinforced Bioactive Glass: An In Vitro Study

Fabrication and Characterization of an Innovative Silver- and Gadolinium-Doped Bioglass for Bone Regeneration

Nanocrystallization as a tool for controlling in vitro dissolution of borophosphate glass

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