Bioactive glass structure and solubility

Aguiar, Hélio L.; González, P.; Serra, J.

doi:10.1016/b978-0-08-100936-9.00002-2

Cited by 9 publications

(9 citation statements)

References 70 publications

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“…At the beginning, crystals were formed around the particles (day 3) and later after 7 days of immersion in SBF, the whole surface of MBGNs powder was completely covered with spherical particulates exhibiting needle-like crystals. These crystals were previously described as hydroxycarbonate apatite crystals by Kozon et al [34], Zheng et al [[35], [37], [39], [41]] and Nawaz et al [32]. The shape of crystals, which is not the typically cauliflower-like shape of HCAp crystals found after exposure of bioactive materials to SBF, is explained as being the consequence of the very small size of the BG particles.…”

Section: Discussionmentioning

confidence: 83%

“…The presence of Si–O–Si stretching vibrations in the range 1000–1200 cm −1 and Si–O–Si bending vibration at 800 cm −1 , as well as Si–O–Si rocking vibration near 470 cm −1 were observed in both samples. The IR spectra are typical for sol-gel derived glasses [39] and no significant differences between MBGNs and Zn-MBGNs are apparent. All the above results indicate that zinc-doping did not influence the structure of the MBGNs.…”

Section: Discussionmentioning

confidence: 99%

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Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications

Neščaková

Zheng

Liverani

et al. 2019

Bioactive Materials

152

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Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and, more recently, in soft tissue repair and wound healing. In this study we produced mesoporous bioactive glass nanoparticles (MBGNs) based on the SiO2–CaO system. With the intention of adding subsidiary biological function, MBGNs were doped with Zn2+ ions. Zn-MBGNs with 8 mol% ZnO content were synthesized via microemulsion assisted sol-gel method. The synthesized particles were homogeneous in shape and size. They exhibited spherical shape, good dispersity, and a size of 130 ± 10 nm. The addition of zinc precursors did not affect the morphology of particles, while their specific surface area increased in comparison to MBGNs. The presence of Zn2+ ions inhibited the formation of hydroxycarbonate apatite (HCAp) on the particles after immersion in simulated body fluid (SBF). No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of immersion. Interestingly, powders containing relatively high amount of zinc released Zn2+ ions in low concentration (0.6–1.2 mg L−1) but in a sustained manner. This releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ ions, indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells (MG-63). Additionally, Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs, which could indicate a favourable later attachment of cells. Due to their advantageous morphological and physiochemical properties, Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications

Neščaková

Zheng

Liverani

et al. 2019

Bioactive Materials

152

View full text Add to dashboard Cite

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“…5 (c)). All samples showed characteristic IR spectra corresponding to sol-gel-derived silicate glasses [ 39 ]. The band at 470 cm −1 was attributed to the Si–O–Si rocking mode [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…The band at 470 cm −1 was attributed to the Si–O–Si rocking mode [ 40 ]. The band at around 790 cm −1 was attributed to the Si–O–Si symmetric stretching vibration [ 39 ]. Moreover, the broad band located between 1000 and 1250 cm −1 was attributed to Si–O–Si stretching vibration and Si–O-(non-bridging oxygen) stretching vibration [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…The band at around 790 cm −1 was attributed to the Si–O–Si symmetric stretching vibration [ 39 ]. Moreover, the broad band located between 1000 and 1250 cm −1 was attributed to Si–O–Si stretching vibration and Si–O-(non-bridging oxygen) stretching vibration [ 39 ]. The synthesis method and the way of cerium addition had no impact on FTIR results.…”

Section: Resultsmentioning

confidence: 99%

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Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications

Kurtuldu

Kaňková

Beltrán

et al. 2021

Materials Today Bio

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Mesoporous bioactive glass nanoparticles (MBGNPs) are attracting significant attention as suitable materials for multifunctional biomedical applications. In this study, cerium was incorporated into MBGNPs using two different approaches. In the first approach, cerium was added to the glass system directly during the synthesis, while in the second approach, cerium was added to the as-synthesized MBGNPs via the template ion-exchange method. The influence of the method of synthesis on the physicochemical properties of nanoparticles was examined by SEM, TEM, XRD, FTIR, and N 2 adsorption-desorption analyses. The MBGNPs exhibited spheroidal morphology and disordered mesoporous structure. XRD analysis confirmed the amorphous nature of the nanoparticles. The chemical composition was determined by the acid digestion method using ICP-OES. The influence of the synthesis method on the specific surface area, mesoporosity, and solubility of synthesized nanoparticles in Tris/HCl (pH 7.4) and acetate (pH 4.5) buffer has also been studied. The obtained Ce containing MBGNPs were non-cytotoxic toward preosteoblast MC3T3-E1 cells in contact with nanoparticles in a concentration of up to 100 μg/mL. The anti-inflammatory effect of Ce containing MBGNPs was tested with lipopolysaccharides (LPS)-induced proinflammatory RAW 264.7 macrophage cells. Ce containing MBGNPs decreased the release of nitric oxide, indicating the anti-inflammatory response of macrophage cells. Ce containing MBGNPs also showed antibacterial activity against S. aureus and E. coli . The mentioned features of the obtained MBGNPs make them useful in a variety of biomedical applications, considering their biocompatibility, anti-inflammatory response, and enhanced antibacterial effect.

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Development of PHBV electrospun fibers containing a borate bioactive glass doped with Co, Cu, and Zn for wound dressings

dos Santos,

Campos,

Anselmi

et al. 2024

J Biomed Mater Res

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Poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) nanofibers embedded with borate glasses of 45B5 composition doped with Co2+, Cu2+, and Zn2+(46.1 B₂O₃26.9‐X CaO24.4 Na₂O2.6 P₂O₅, X CoO/CuO/ZnO mol % (X = 0–5)) were produced by electrospinning for wound healing applications. Prior to their addition, the glasses exhibited two broad halos typical of a vitreous borate network, which were mainly composed of ring‐type metaborate structural units. The particle distribution in the PHBV nanofibers embedded with 45B5 borate bioactive glasses is present in isolated and agglomerated states, being partially coated by a polymeric layer—except for the cobalt‐doped glass, which resulted in a successful encapsulation with 100% embedding efficiency. The incorporation of the glasses reduced the PHBV crystallinity degree and its decomposition temperature, as well as its mechanical properties, including Young's modulus, tensile strength, and elongation at break. The neat PHBV fibers and those containing the cobalt‐doped glasses demonstrated great cytocompatibility with human keratinocytes (HaCat), as suggested by the high cell viability after 7 days of exposure. Further studies are needed to fully understand the wound healing potential of these fibers, but our results significantly contribute to the area.

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Bioactive glass structure and solubility

Cited by 9 publications

References 70 publications

Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications

Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications

Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications

Development of PHBV electrospun fibers containing a borate bioactive glass doped with Co, Cu, and Zn for wound dressings

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