“…As previously reported, the decrease of cell number has been associated with borosilicate BaG ionic species induced restriction of cell proliferation and accompanying strong osteogenesis (Ojansivu et al, ). Moreover, boron ion induced effect on cell morphology has also been indicated by previous research (Brown et al, ; Rodriguez, Gonzalez, Rios, & Cambiazo, ), together with observed changes to cytoskeleton, cell adhesion, and signaling pathways (Ojansivu et al, , ). To the point, we observed a similar effect with borosilicate bioactive glass 2‐06 based BaG EM‐OM condition with strong osteocalcin production along with cubic cell morphology producing less oriented structures and truncated tubular growth.…”