Bioactive glass hybrids: a simple route towards the gelatin–SiO<sub>2</sub>–CaO system

Dieudonné, Xavier; Montouillout, V.; Jallot, Édouard; Fayon, Franck; Lao, Jonathan

doi:10.1039/c3cc49113g

Cited by 17 publications

(18 citation statements)

References 33 publications

(64 reference statements)

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“…Calcium incorporation could be achieved with Ca(NO 3 ) 2 by heating the dried gels above 400 °C , and toxic nitrates were also burnt off at this temperature . In contrast, calcium ions incorporate the glass network at room temperature when employing calcium alkoxides (Ca(OR) 2 where R is an alkyl group) as sol–gel precursors, as demonstrated in many studies on sol–gel derived BAG‐based materials involving calcium methoxyethoxide and calcium ethoxide . Silicate glasses obtained by sol–gel chemistry differ from melt‐quenched glasses in terms of structure.…”

Section: Glassesmentioning

confidence: 99%

Optimized Bioactive Glass: the Quest for the Bony Graft

Granel

Bossard

Nucke

et al. 2019

Adv Healthcare Materials

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Technological advances have provided surgeons with a wide range of biomaterials. Yet improvements are still to be made, especially for large bone defect treatment. Biomaterial scaffolds represent a promising alternative to autologous bone grafts but in spite of the numerous studies carried out on this subject, no biomaterial scaffold is yet completely satisfying. Bioactive glass (BAG) presents many qualifying characteristics but they are brittle and their combination with a plastic polymer appears essential to overcome this drawback. Recent advances have allowed the synthesis of organic–inorganic hybrid scaffolds combining the osteogenic properties of BAG and the plastic characteristics of polymers. Such biomaterials can now be obtained at room temperature allowing organic doping of the glass/polymer network for a homogeneous delivery of the doping agent. Despite these new avenues, further studies are required to highlight the biological properties of these materials and particularly their behavior once implanted in vivo. This review focuses on BAG with a particular interest in their combination with polymers to form organic–inorganic hybrids for the design of innovative graft strategies.

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Section: Glassesmentioning

confidence: 99%

Optimized Bioactive Glass: the Quest for the Bony Graft

Granel

Bossard

Nucke

et al. 2019

Adv Healthcare Materials

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“…), where each end of the polymer can be functionalised with organo-silicate cross linkers; 3,9,10 and (iii) polymers containing pending alkoxysilane groups that allow covalent coupling. 2,[11][12][13] These pending groups can be a result of functionalisation by organo-silicates molecules or by including monomeric units such as 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) in radical polymerisations. [14][15][16] The latter has the benefit of allowing a better integration of alkoxysilane precursor as a part of the polymer structure as post-functionalization has been shown to be sensitive to the polymer used and experimental conditions.…”

Section: Introductionmentioning

confidence: 99%

A structural and physical study of sol–gel methacrylate–silica hybrids: intermolecular spacing dictates the mechanical properties

Maçon

Page

Chung

et al. 2015

Phys. Chem. Chem. Phys.

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Sol-gel hybrids are inorganic/organic co-networks with nanoscale interactions between the components leading to unique synergistic mechanical properties, which can be tailored, via a selection of the organic moiety. Methacrylate based polymers present several benefits for class II hybrids (which exhibit formal covalent bonding between the networks) as they introduce great versatility and can be designed with a variety of chemical side-groups, structures and morphologies. In this study, the effect of high cross-linking density polymers on the structure-property relationships of hybrids generated using poly(3-trimethoxysilylpropyl methacrylate) (pTMSPMA) and tetraethyl orthosilicate (TEOS) was investigated. The complexity and fine scale of the co-network interactions requires the development of new analytical methods to understand how network evolution dictates the wide-ranging mechanical properties. Within this work we developed data manipulation techniques of acoustic-AFM and solid state NMR output that provide new approaches to understand the influence of the network structure on the macroscopic elasticity. The concentration of pTMSPMA in the silica sol affected the gelation time, ranging from 2 h for a hybrid made with 75 wt% inorganic with pTMSPMA at 2.5 kDa, to 1 minute for pTMSPMA with molecular weight of 30 kDa without any TEOS. A new mechanism of gelation was proposed based on the different morphologies derived by AC-AFM observations. We established that the volumetric density of bridging oxygen bonds is an important parameter in structure/property relationships in SiO2 hybrids and developed a method for determining it from solid state NMR data. The variation in the elasticity of pTMSPMA/SiO2 hybrids originated from pTMSPMA acting as a molecular spacer, thus decreasing the volumetric density of bridging oxygen bonds as the inorganic to organic ratio decreased.

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“…Calcium alkoxide precursors appear a more promising route and have been used to obtain monoliths and fibres with homogeneous silica and calcium networks without the need for thermal treatment [46,72,77,81]. The incorporation of calcium into the porous fibres using calcium alkoxides in the formulations and processing is the focus of current work.…”

Section: Surface Area and Wettabilitymentioning

confidence: 99%

“…6b), indicating a polycondensation mean reaction efficiently of, 91.43 ± 4.29 and 89.77 ± 3.72%, both, respectively. Several reports have highlighted an organic phase is in the region of 50-70% and is beneficial to impart flexibility to the hybrid [28,29,47,77,78].…”

Section: Structural Characterisation and Inorganic Contentmentioning

confidence: 99%

Hybrid sol–gel inorganic/gelatin porous fibres via solution blow spinning

et al. 2017

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Hybrid sol-gel inorganic-organic fibres offer great potential in tissue engineering and regenerative medicine. A significant challenge is to process them using scalable technologies into useful scaffolds that provide control over fibre diameter, morphology, mechanical properties, ion release, degradation and cell response. In this work we develop formulations that are amenable to processing via solution blow spinning (SBS), a rapid technique using simple equipment to spray nano-/ micro-fibres without any electric fields. The technique is extended to produce porous class I and II hybrid fibres using cryogenic SBS, with formulations developed based on tetraethyl orthosilicate/gelatin that are relatively facile to lyophilise. The formulations developed here take advantage of the reversible thermally activated conformation change of gelatin in aqueous solutions from random coil to triple helix to enable viscosity tuning and therefore fibre spinning. Gelatin is functionalised with (3-glycidyloxypropyl)trimethoxysilane to produce class II hybrids which exhibit controllable time-and temperature-dependent viscosity profiles which can be tuned for spinning into highly porous fibres.Ryan D. Greenhalgh and William S. Ambler are joint first authors due to equal contribution.

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Bioactive glass hybrids: a simple route towards the gelatin–SiO₂–CaO system

Cited by 17 publications

References 33 publications

Optimized Bioactive Glass: the Quest for the Bony Graft

Optimized Bioactive Glass: the Quest for the Bony Graft

A structural and physical study of sol–gel methacrylate–silica hybrids: intermolecular spacing dictates the mechanical properties

Hybrid sol–gel inorganic/gelatin porous fibres via solution blow spinning

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Bioactive glass hybrids: a simple route towards the gelatin–SiO2–CaO system

Cited by 17 publications

References 33 publications

Optimized Bioactive Glass: the Quest for the Bony Graft

Optimized Bioactive Glass: the Quest for the Bony Graft

A structural and physical study of sol–gel methacrylate–silica hybrids: intermolecular spacing dictates the mechanical properties

Hybrid sol–gel inorganic/gelatin porous fibres via solution blow spinning

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Product

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Bioactive glass hybrids: a simple route towards the gelatin–SiO₂–CaO system