Bioactive Glass: An <i>In‐Vitro</i> Comparative Study of Doping with Nanoscale Copper and Silver Particles

Goh, Yi Fan; Alshemary, Ammar Z.; Akram, Mahreen; Kadir, Mohammed Rafiq Abdul; Hussain, Rafaqat

doi:10.1111/ijag.12061

Cited by 99 publications

(95 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study, incorporation of Ag 2 O into a bioactive glass enabled antimicrobial properties without compromising its bioactivity [124]. Antibacterial surfaces are of particular interest for reducing biomaterial-centered infection and, thereby, enhancing tissue integration and bone regeneration [124,143,144].…”

Section: Biological Propertiesmentioning

confidence: 99%

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

View full text Add to dashboard Cite

Critical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.

show abstract

Section: Biological Propertiesmentioning

confidence: 99%

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

View full text Add to dashboard Cite

show abstract

“…The studies have showed that Ag + ions have lower minimum inhibitory concentrations against bacteria including S. aureus and E. coli (MIC, 0.03‐8 vs 256‐448 μg/mL) and smaller Lethal doses 50 for L929 mouse fibroblast cells (LD50, 3.5×10 −3 vs 2.3×10 −1 mmol/L) than Cu 2+ ions . Fast initial release of Ag + ions from Ag‐doped bioactive glass makes it a better rapid bacteria‐killing agent than Cu‐doped glass …”

Section: Resultsmentioning

confidence: 99%

“…The Ag‐containing bioactive glass (Ag‐glass) powders were sol‐gel prepared and exhibited antibacterial activity; however, the structure and properties of sol‐gel prepared Ag‐glass coatings have rarely been studied . In this work, AgNO 3 was added into the SiO 2 ·CaO·P 2 O 5 sol, and the glass films containing different silver contents were dip coated on titanium substrate.…”

Section: Introductionmentioning

confidence: 99%

Sol‐gel preparation and properties of Ag‐containing bioactive glass films on titanium

Alajmi

Shen

et al. 2017

Int J Applied Ceramic Tech

View full text Add to dashboard Cite

Ag‐containing bioactive glass films (Ag/Ca atomic ratios of 0, 5% and 10%) were sol‐gel prepared for bioactive and antibacterial modification of titanium. The gel powders calcined at 610°C are mainly amorphous confirmed by x‐ray diffraction, but small diffraction peaks of Ca3SiO5 and silver are detected. The film surface is porous with the pore size of ~200 nm. Silver‐rich sub‐micro particles with sizes of 100‐480 nm are present at the surface of Ag‐glass films. CaP phase, metallic silver and silica are detected by x‐ray photoelectron spectroscopy. The mean apparent bonding strength of the films is as high as 21±1 MPa measured by the pull‐off test. The potentiodynamic polarization test shows that the coated samples have better corrosion resistance than the polished sample. The Ag‐glass coatings and their wafer samples exhibit antibacterial activity against S. aureus. The coated samples are covered by apatite layer after soaked in the simulated body fluid for 2 weeks, demonstrating their bioactivity.

show abstract

“…In the last years, several studies have shown proper antibacterial properties achieved by different formulations of bioactive glasses incorporating several oxides and the effects of biologically active ions on bone tissue engineering have been discussed in literature . In addition, commercial products based on bioactive glass (melt‐derived, composition SiO 2 53%, Na 2 O 23%, CaO 20%, P 2 O 5 4%) are being successfully applied in the clinic to treat osteomyelitis and the application of BGs to treat bone infections by the effect of pH increase is well demonstrated in literature .…”

Section: Organic Agents Incorporated Into Bioactive Glassmentioning

confidence: 99%

Anti‐biofilm properties of bioactive glasses embedding organic active compounds

Galárraga-Vinueza

Mesquita‐Guimarães

Magini

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

Bioactive glasses (BGs) are promising materials for bone repair due to their desirable properties such as osteoconductivity, biodegradability, angiogenic potential, and antibacterial activity. Ionic dissolution products from bioactive glasses increase the medium pH inhibiting surrounding bacteria proliferation. The activity of BGs against biofilm formation has been enhanced by incorporating organic antibacterial compounds. The aim of this review was to summarize evidence in literature which assesses the efficacy of antibacterial and anti-biofilm compounds embedded in bioactive glasses to prevent peri-implant infection during bone healing. A PubMed bibliographical research was carried out including articles published in the last 20 years. Most previous studies evaluated antibacterial efficiency in planktonic cultures but did not investigate biofilm inhibition, underestimating biofilm clinical relevance. Multifactorial features such as biocompatibility of embedded compounds, receptor site characteristics, and drug delivery efficiency have been found to influence the bioactive glass capability of acting both as an anti-biofilm agent and as a bone repairing biomaterial. Accordingly, further in vitro and in vivo studies are required to select the most promising anti-biofilm agents which should be incorporated into bioactive glasses to counteract biofilm proliferation, without inducing toxic effects on human cells, and with the added functionality of promoting bone regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 672-679, 2017.

show abstract

Bioactive Glass: An In‐Vitro Comparative Study of Doping with Nanoscale Copper and Silver Particles

Cited by 99 publications

References 70 publications

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Sol‐gel preparation and properties of Ag‐containing bioactive glass films on titanium

Anti‐biofilm properties of bioactive glasses embedding organic active compounds

Contact Info

Product

Resources

About