Bioactive Flavonoids from Tephrosia Purpurea

Abstract

A new naturally occurring flavonol diglycoside, tamarixetin 3-O-β-glucopyranoside-7-O-α-rhamnopyranoside, was isolated along with two known flavonol diglycosides from the aerial parts of Tephrosia purpurea (L.) Pers. (Fabaceae). Bioassay guided fractionation of the light petroleum extract afforded two bioactive 5-deoxyflavones, pseudosemiglabrin and glabratephrin. Both showed cytotoxicity to the Hepg2 hepatic human cell line with IC 50 values of 0.87 and 4.03 μg/mL, respectively. The isolated compounds were characterized by spectroscopic (UV, 1 H, 13 C, HMQC and HMBC NMR) and spectrometric (EI-MS, ESI-MS) analyses.

Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect

“…Curcumin HgCl 2 -induced liver toxicity in rats 217 μM/kg Oral ↓ the elevated ALP, LDH, TB, c-GT, MDA, and TG, as well as ↑ the protective effect on drugmetabolizing CYP 2E1 enzymes [123] Lindane-induced oxidative stress in male rats 272 and 544 μM/kg Oral Decreases LPO and ↑ liver antioxidant enzyme SOD, GSH, CAT, GST), GPx, GR and NADPH quinine reductase (QR) Evidence-Based Complementary and Alternative Medicine e flavonoid-rich fraction of another hepatoprotective plant (HP) T. purpurea containing quercetin (5), coumarins, flavonoids, and flavanones protects against rat hepatotoxicity induced by CCl 4 at a dose of 100 mg/kg dose via reduction of the elevated level of serum SGOT, SGPT, ALP, and bilirubin (Figure 5) [162]. e rutin (1), catechin (4), quercetin (5), kamferol (6), and luteolin (7) flavonoids have also been isolated from different crude extracts of A. spinosus, C. tinctorius, C. fistula, and T. purpurea, which further supports their reported and traditional liver-protective activity (Figure 7) [163][164][165][166]. Flavonoids and phenolics such as myricetin ( 8), quercetin 3-O-xylosyl-(1 ⟶ 2) rhamnoside ( 9), ellagic acid rahmnoside (10), and rosmarinic acid (11) from S. jambos leaf extracts have been identified using HPLC-PDA-MS/MS that showed promising liver-protective activity in CCl 4 -induced liver injury rats (Figure 8) [167].…”

Natural Products from the Genus Tephrosia

“…The genus Tephrosia , belonging to the Leguminosae family, is a large pantropical genus of more than 350 species, many of which have important traditional uses [1,2]. Phytochemical investigations have revealed the presence of glucosides, rotenoids, isoflavones, chalcones, flavanones, flavanols, and prenylated flavonoids [1,2,3,4,5,6,7,8,9] of chemotaxonomic importance in the genus [10]. Moreover, bioactivity has been studied extensively, indicating that chemical constituents and extracts of the genus Tephrosia exhibited diverse bioactivities, such as insecticidal [11], antiviral [12], antiprotozoal [13], antiplasmodial [14] and cytotoxic [15] activities.…”