Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

Suganthy, Natarajan; Devi, Kasi Pandima; Nabavi, Seyed Fazel; Braidy, Nady

doi:10.1016/j.biopha.2016.10.011

Cited by 181 publications

(129 citation statements)

References 180 publications

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“…Decrease in the activity of AChE in the I/R group indicated abnormality in synaptic neurotransmission, and mitigation of the decreased activity in KV-pretreated groups supports previous finding that flavonoids modulate critical neuronal signaling pathways [51]. Quercetin, the reference flavonoid employed in this study has been described as a cognitive enhancer [20]. …”

Section: Discussionsupporting

confidence: 64%

Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits

et al. 2017

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Background: Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. Purpose: This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury. Methods: KV was administered at a dose of 100 or 200 mg/kg to male Wistar rats 1 h before a 30 min BCCAO/4 h reperfusion (I/R). This was followed by neurobehavioral assessment and biochemical evaluations of cation levels, oxidative stress indicators, lactate dehydrogenase activity and acetylcholinesterase (AChE) activity in the brain of animals. Conclusion: KV significantly restored altered cortical and striatal Ca²⁺, Na⁺, K⁺ and Mg²⁺ levels, ameliorated redox imbalance, lactic acidosis and modified AChE activity caused by I/R injury. The favourable neurobehavioural effects of KV correlated with biochemical outcomes. The pharmacological potential of KV in the treatment and management of ischemic stroke and allied pathological conditions via multiple targets (neurotransmitter metabolism, bioenergetic failure and ionic homeostasis) is highlighted by the study.

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Section: Discussionsupporting

confidence: 64%

Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits

et al. 2017

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“…Indeed, quercetin destabilizes and increases the clearance of abnormal proteins such as beta-amyloid peptide and also hyperphosphorylated tau protein (23). Other neuroprotection mechanisms have been postulated for quercetin including regulation of synaptic plasticity, learning and neuronal adaptation via signaling pathways of the PGC-1α/FNDC5/BDNF, ERK/CREB/BDNF, PI3K/AKT/Nrf2 and activation of SIRT1 (22)(23)(24). Therefore, quercetin interactions with these pathways may be responsible for its role in the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain

Rahvar¹,

Owji²,

Mashayekhi³

2018

BLL

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Quercetin is a ubiquitous fl avonoid found in many plants. Neuroprotective effects of quercetin have been shown in several in vitro and in vivo studies, but its mechanism of action has not been fully defi ned yet. Brain-derived neurotrophic factor (BDNF) is a fundamental neurotrophin with vital functions in the survival of neuronal cells. In the present study, we aimed to investigate the effects of quercetin on expression of BDNF mRNA in the hippocampus of rat brain. METHODS: Male rats were daily gavaged with quercetin (10, 20 or 50 mg/kg·bwt) for 30 days. Hippocampal levels of the BDNF transcripts were assessed using quantitative (q) RT-PCR. RESULTS: Quercetin at doses of 20 and 50 mg/kg caused a signifi cant increase in the mRNA expression of BDNF as compared with the control group. Quercetin treatment at a dose of 10 mg/kg failed to cause any signifi cant changes in the levels of BDNF mRNA CONCLUSION: Our fi ndings suggest that the neuroprotective effects of quercetin may be at least partly due to its inducing effects on the expression levels of the BDNF mRNA (Fig. 1, Ref. 40). Text in PDF www.elis.sk.

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“…Quercetin has been shown to exert protective effects against cardiovascular diseases like atherosclerosis and ischemia reperfusion-induced injury, as well as anti-cancer and anti-inflammatory effects [12]. Recent studies have also revealed the neuro-protective effects of quercetin in many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and against hypoxiainduced injury and neurotoxic chemical-induced damage [13,14]. However, the mechanisms underlying these effects were not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…However, the mechanisms underlying these effects were not fully understood. It was previously suggested that quercetin exerted neuro-protective effects and cellular defenses against oxidative stress via the induction of Nrf2-ARE (nuclear factor erythroid 2-related factor 2-antioxidant response element) and the anti-oxidant enzyme paraoxonase 2 (PON2) [13].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of quercetin on bupivacaine-induced neurotoxicity via T-type calcium channel inhibition

Chen¹,

Wu²,

Tang³

et al. 2017

Trop. J. Pharm Res

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Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

Cited by 181 publications

References 180 publications

Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits

Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits

Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain

Protective effect of quercetin on bupivacaine-induced neurotoxicity via T-type calcium channel inhibition

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