Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects

Nie, Qixing; Hu, Jielun; He, Guangming; Li, Mingzhi; Sun, Yonggan; Chen, Haihong; Zuo, Sheng; Fang, Qin; Huang, Xiao‐Jun; Yin, Jingdong; Nie, Shaoping

doi:10.1021/acs.jafc.1c01465

Cited by 51 publications

(23 citation statements)

References 46 publications

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“…Since LF psyllium induced the greatest metabolomic change compared to LF, we performed a (Spearman) correlation between the microbiome and the metabolome data in order to elucidate potential interactions. Gut microbial profile correlates with azoles, organic acids and carbohydrates (Figure 5H) Further exploration of genera modulated by psyllium as determined in the aforementioned microbiome analysis, revealed that Parasutterella and Akkermansia had strong negative correlation with glucose (R −0.67, −0.73 respectively p < 0.05), type 2 diabetes associated metabolites 3-methyl-2-oxovaleric acid (R −0.72, −0.78 respectively p < 0.05), and citrulline (R −0.77, −0.71 respectively p < 0.05) [26,27], whilst Enterorhabdus, Odoribacter and Lachnoclostridium had the opposite effect (Table 3). Full correlation analysis table is given in Supplementary Data (Table S3).…”

Section: Dfs Have a Profound Impact On Cecal Metabolomic Profilementioning

confidence: 99%

Differential Influence of Soluble Dietary Fibres on Intestinal and Hepatic Carbohydrate Response

et al. 2021

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Refined foods are commonly depleted in certain bioactive components that are abundant in ‘natural’ (plant) foods. Identification and addition of these ‘missing’ bioactives in the diet is, therefore, necessary to counteract the deleterious impact of convenience food. In this study, multiomics approaches were employed to assess the addition of the popular supplementary soluble dietary fibers inulin and psyllium, both in isolation and in combination with a refined animal feed. A 16S rRNA sequencing and 1H NMR metabolomic investigation revealed that, whilst inulin mediated an increase in Bifidobacteria, psyllium elicited a broader microbial shift, with Parasutterella and Akkermansia being increased and Enterorhabdus and Odoribacter decreased. Interestingly, the combination diet benefited from both inulin and psyllium related microbial changes. Psyllium mediated microbial changes correlated with a reduction of glucose (R −0.67, −0.73, respectively, p < 0.05) and type 2 diabetes associated metabolites: 3-methyl-2-oxovaleric acid (R −0.72, −0.78, respectively, p < 0.05), and citrulline (R −0.77, −0.71, respectively, p < 0.05). This was in line with intestinal and hepatic carbohydrate response (e.g., Slc2a2, Slc2a5, Khk and Fbp1) and hepatic lipogenesis (e.g., Srebf1 and Fasn), which were significantly reduced under psyllium addition. Although established in the liver, the intestinal response associated with psyllium was absent in the combination diet, placing greater significance upon the established microbial, and subsequent metabolomic, shift. Our results therefore highlight the heterogeneity that exists between distinct dietary fibers in the context of carbohydrate uptake and metabolism, and supports psyllium containing combination diets, for their ability to negate the impact of a refined diet.

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Section: Dfs Have a Profound Impact On Cecal Metabolomic Profilementioning

confidence: 99%

Differential Influence of Soluble Dietary Fibres on Intestinal and Hepatic Carbohydrate Response

et al. 2021

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“…Indole is the precursor of indoxyl sulfate, which linked with cancer, host metabolic disorders, cardiovascular disease, type 2 diabetes, hypertension, and induced intestinal barrier dysfunction [ 42 , 43 , 44 , 45 , 46 , 47 ]. It was reported that dietary supplements of beneficial substances effectively decreased indole-derived metabolites in the host [ 48 , 49 , 50 ]. LPEPS oral administration remarkedly decreased purine and pyrimidine nucleosides, including xanthosine and uridine, in the feces of AOM/DSS-treated C57BL/6 mice.…”

Section: Discussionmentioning

confidence: 99%

“…LPEPS oral administration decreased 3-hydroxynonanoyl carnitine in the AOM/DSS-treated mice. A number of studies have shown that carnitine was enriched in colon cancer and type 2 diabetes [ 46 , 55 , 56 , 57 , 58 ], while natural active substance supplementation effectively decreased concentration of carnitine in type 2 diabetes [ 46 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Exopolysaccharide Produced by Lactiplantibacillus plantarum-12 Alleviates Intestinal Inflammation and Colon Cancer Symptoms by Modulating the Gut Microbiome and Metabolites of C57BL/6 Mice Treated by Azoxymethane/Dextran Sulfate Sodium Salt

Song

Sun

et al. 2021

Foods

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Exopolysaccharide produced by Lactiplantibacillus plantarum-12 (LPEPS) exhibited the anti-proliferating effect on human colon cancer cell line HT-29 in vitro. The purpose of the study was to determine the alleviating effects of LPEPS on colon cancer development of the C57BL/6 mice treated by azoxymethane/dextran sulfate sodium salt (AOM/DSS). The C57BL/6 mice treated by AOM/DSS were orally administered LPEPS daily for 85 days. The results showed that LPEPS oral administration enhanced colon tight-junction protein expression and ameliorated colon shortening and tumor burden of the AOM/DSS treated mice. Furthermore, LPEPS oral administration significantly reduced pro-inflammatory factors TNF-α, IL-8, and IL-1β levels and increased anti-inflammatory factor IL-10 level in the serum of the AOM/DSS-treated mice. LPEPS oral administration reversed the alterations of gut flora in AOM/DSS-treated mice, as evidenced by the increasing of the abundance of Bacteroidetes, Bacteroidetes/Firmicutes ratio, Muribaculaceae, Burkholderiaceae, and norank_o__Rhodospirillales and the decreasing of the abundance of Firmicutes, Desulfovibrionaceae, Erysipelotrichaceae, and Helicobacteraceae. The fecal metabolites of the AOM/DSS-treated mice were altered by LPEPS oral administration, involving lipid metabolism and amino acid metabolism. Together, these results suggested that LPEPS oral administration alleviated AOM/DSS-induced colon cancer symptoms of the C57BL/6 mice by modulating gut microbiota and metabolites, enhancing intestine barrier, inhibiting NF-κB pathway, and activating caspase cascade.

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“…AG was dissolved with distilled water and prepared into a solution with a concentration of 3.9 mg/ml. The intragastric dose of arabinogalactan solution (A) was 390 mg/kg/day (Nie et al, 2021). The fresh bacterial medium with B. longum (B) or F. prausnitzii (F) was centrifuged and suspended again into a bacterial suspension with sterile PBS.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…Sun et al, 2021). Our previous study has shown that AG can increase body weight, reduce fasting glucose, change the relative abundance of gut microbiota, and alleviate impaired glucose tolerance in T2D rats (Nie et al, 2021). However, the role of AG on IR in HFD‐induced mice is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Arabinogalactan, Bifidobacterium longum, and Faecalibacterium prausnitzii improve insulin resistance in high‐fat diet‐induced C57BL/6J mice

Sun

Zhang

et al. 2022

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The occurrence and development of insulin resistance (IR) are usually related to the change of gut microbiota. Our previous study showed that arabinogalactan (AG) could selectively increase the relative abundance of Bifidobacterium longum and Faecalibacterium prausnitzii in in vitro fermentation. However, their effect on IR remains unclear. In the current study, we investigated the effects of AG, B. longum, F. prausnitzii and their combinations on insulin-resistant mice. Intake of AG and those two strains reduced the body weight, fat accumulation, and homeostasis model assessment of IR of the mice with IR, and decreased the level of serum glucose, insulin, and lipids. Meanwhile, they could alleviate the injury of the liver. Moreover, AG, B. longum, and F. prausnitzii regulated the production of short-chain fatty acids and elevated the abundance of gut probiotics such as Lactobacillus, Lactococcus, and Bifidobacterium. However, the effect of giving only AG or a single strain was weaker than the combination of AG, B. longum, and F. prausnitzii. Our study attempted to find a new way to prevent the development of type 2 diabetes in the early stage and provided evidence for new therapy against IR with a combination of prebiotics and two bacterial strains of gut origin.

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Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects

Cited by 51 publications

References 46 publications

Differential Influence of Soluble Dietary Fibres on Intestinal and Hepatic Carbohydrate Response

Differential Influence of Soluble Dietary Fibres on Intestinal and Hepatic Carbohydrate Response

Exopolysaccharide Produced by Lactiplantibacillus plantarum-12 Alleviates Intestinal Inflammation and Colon Cancer Symptoms by Modulating the Gut Microbiome and Metabolites of C57BL/6 Mice Treated by Azoxymethane/Dextran Sulfate Sodium Salt

Arabinogalactan, Bifidobacterium longum, and Faecalibacterium prausnitzii improve insulin resistance in high‐fat diet‐induced C57BL/6J mice

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