Bioactive Constituents of Conyza Albida

Pacciaroni, Adriana; Espinar, L. Ariza; Mongelli, E.; Romano, Anabela; Ciccia, G.; Silva, Gloria L.

doi:10.3390/50300571

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…(Celastraceae) (Brenniesen and Geisshusler, 1985;Carlini, 2003), Conyza albida Spreng. (Asteraceae) (Pacciaroni et al, 2000;Stamatis et al, 2003), Lippia javanica (Burm. f.) Spreng.…”

Section: Resultsunclassified

In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

Clarkson

Maharaj²,

Crouch

et al. 2004

Journal of Ethnopharmacology

454

267

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The increasing prevalence and distribution of malaria has been attributed to a number of factors, one of them being the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of new chemically diverse antimalarial agents. The present study reports on the in vitro antiplasmodial activity of 134 plant taxa native to or naturalised in South Africa, representing 54 families, which were selected semi-quantitatively using weighted criteria. The plant extracts were tested for in vitro activity against a Plasmodium falciparum strain D10 using the parasite lactate dehydrogenase (pLDH) assay. Of the 134 species assayed, 49% showed promising antiplasmodial activity (IC(50)< or = 10 microg/ml), while 17% were found to be highly active (IC(50)< or = 5 microg/ml). Several plant species and genera were shown for the first time to possess in vitro antiplasmodial activity. These results support a rational rather than random approach to the selection of antiplasmodial screening candidates, and identify a number of promising taxa for further investigation as plant-based antimalarial agents.

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“…(Celastraceae) (Brenniesen and Geisshusler, 1985;Carlini, 2003), Conyza albida Spreng. (Asteraceae) (Pacciaroni et al, 2000;Stamatis et al, 2003), Lippia javanica (Burm. f.) Spreng.…”

Section: Resultsunclassified

In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

Clarkson

Maharaj²,

Crouch

et al. 2004

Journal of Ethnopharmacology

454

267

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“…Terpinen-4-ol can induce caspase-dependent apoptosis in human melanoma cells [7], and has been shown to cause differentiation of human myelocytic cell line HL-60 [8]. Furthermore, spathulenol has a GI 50 value of 83.8 μM when tested in the KB cell cytotoxicity assay and can moderately inhibit human topoisomerase I [9]. Limonene, terpinen-4-ol and spathulenol are all found in high concentrations in the essential oil, which could explain, in part, the anticancer activity.…”

mentioning

confidence: 99%

Chemical Composition of Leaf Essential Oil of Hedyosmum arborescens and Evaluation of Its Anticancer Activity

Sylvestre

Pichette

Longtin

et al. 2007

Natural Product Communications

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The essential oil of Hedyosmum arborescens Sw. (Chloranthaceae), a native plant of the Caribbean archipelago, was extracted by hydrodistillation. The chemical composition of the volatile fraction was determined by GC and GC-MS analyses and 50 components were identified. The major components are α-phellandrene (11.4%), bicyclogermacrene (10.6%) and sabinene (9.7%). The anticancer activities of these extracts were assessed against human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. The leaf essential oil of H. arborescens was found to be moderately active against both cancer cell lines with GI50 values of 158 ± 7 μg/mL for A-549 and 178 ± 9 μg/mL for DLD-1.

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“…Other studies reported that an AEE of Conyza bonariensis also showed cytotoxicity with the brine shrimp ( Artemia ssp.) toxicity test [ 13 ]. Moreover, four compounds isolated from C. albida exhibited cytotoxic activities against the tumor KB cell line at concentrations of 7–19 μ g/mL [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, Anti-Inflammatory, Antiparasitic, and Cytotoxic Activities ofLaennecia confusa

Ruiz

Richard-Greenblatt

Juárez

et al. 2012

The Scientific World Journal

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The current paper investigated the potential benefit of the traditional Mexican medicinal plant Laennecia confusa (Cronquist) G. L. Nesom (Asteraceae). Fractions from the hexane, chloroform, methanol, and aqueous extracts were analyzed for antibacterial, antifungal, anti-inflammatory, and antiparasitic activities. The antimicrobial activity of the extracts and fractions was assessed on bacterial and fungal strains, in addition to the protozoa Leishmania donovani, using a microdilution assay. The propensity of the plant's compounds to produce adverse effects on human health was also evaluated using propidium iodine to identify damage to human macrophages. The anti-inflammatory activity of the extracts and fractions was investigated by measuring the secretion of interleukin-6. Chemical analyses demonstrated the presence of flavonoids, cyanogenic and cardiotonic glycosides, saponins, sesquiterpene lactones, and triterpenes in the chloroform extract. A number of extracts and fractions show antibacterial activity. Of particular interest is antibacterial activity against Staphylococcus aureus and its relative methicillin-resistant strain, MRSA. Hexanic and chloroformic fractions also exhibit antifungal activity and two extracts and the fraction CE 2 antiparasitic activity against Leishmania donovani. All bioactive extracts and fractions assayed were also found to be cytotoxic to macrophages. In addition, the hexane and methane extracts show anti-inflammatory activity by suppressing the secretion of interleukine-6.

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Bioactive Constituents of Conyza Albida

Abstract: Alkynes and spathulenol were isolated from Conyza albida (Asteraceae); some of the compounds were lethal against Artemia sp. and cytotoxic against KB cells.

Cited by 7 publications

References 4 publications

In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

Chemical Composition of Leaf Essential Oil of Hedyosmum arborescens and Evaluation of Its Anticancer Activity

Antimicrobial, Anti-Inflammatory, Antiparasitic, and Cytotoxic Activities ofLaennecia confusa

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