Bioactive Compounds from Marine Sponge Associates: Antibiotics from Bacillus Sp.

Santhi, Lanka Sri; Vssl, Prasad Talluri; Sy, Nagendra; E, Radha Krishna

doi:10.4172/2329-6836.1000266

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…The bacteriostatic mode of biofilm inhibition by the compounds isolated from the natural sources has been documented (Trentin et al, 2013). Generally, the synthesis of bioactive compounds by the bacteria Bacillus species has frequently been documented; some of the reported species are B. amyloliquefaciens, B. cereus, B. laterosporus, B. licheniformis, B. silvestris and B. subtilis (Mondol et al, 2013;Santhi et al, 2017). These compounds (polyketides, peptides and fatty acids) have shown antimicrobial, antifungal, antibiofilm, antifouling, anticancer, antialgal and bioinsecticidal activities (Baruzzi et al, 2011;Hamdache et al, 2011;Ben Khedher et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm activity of symbiotic Bacillus species associated with marine gastropods

Viju¹,

Punitha²,

Satheesh

2020

Ann Microbiol

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Purpose: Generally, symbiotic marine bacteria are renowned for the synthesis of compounds with bioactive properties, and this has been documented in many previous studies. Therefore, the present study was aimed to isolate novel bacterial symbionts of gastropods that have the ability to synthesize bioactive compounds. These bioactive compounds could be used effectively as antibiofilm agents in order to overcome the problems associated with biofilm. Methods: The bacteria associated with the surface of marine gastropods were isolated and characterized. Following this, the bacterial metabolites were extracted and their antibiofilm effect was evaluated on biofilm-forming bacteria on artificial substrates. Moreover, the biofilm-forming bacterium Alteromonas sp. was treated with the extracts of symbiotic bacteria in order to evaluate the influence of extracts over the synthesis of extracellular polymeric substance (EPS). Besides, the biologically active chemical constituents of the extracts were separated using thin-layer chromatography and subjected to gas chromatography and mass spectrometry (GC-MS) analysis for characterization. Results: Three bacterial strains belonging to the species Bacillus firmus, Bacillus cereus and Bacillus subtilis were identified from the bacterial community associated with the gastropods. The antibiofilm assays revealed that the extract of three symbiotic bacteria significantly (p < 0.05) reduced the biofilm formation by the marine bacterium Alteromonas sp. on artificial materials. Also, the EPS synthesis by Alteromonas sp. was significantly inhibited due to symbiotic bacterial extract treatment. The chemical composition of the bioactive fraction isolated from the symbiotic bacteria extract revealed that most of the detected compounds were belonging to aromatic acid, fatty acid and carboxylic acid. Conclusion: The results of this study clearly revealed that the bacteria belonging to the above listed Bacillus species can be considered as a promising source of natural antibiofilm agents.

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Section: Discussionmentioning

confidence: 99%

Antibiofilm activity of symbiotic Bacillus species associated with marine gastropods

Viju¹,

Punitha²,

Satheesh

2020

Ann Microbiol

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“…Мировой опыт морской фармации свидетельствует об огромном потенциале морских гидробионтов в качестве сырья для оригинальных фармацевтических субстанций и лекарств [46][47][48][49]. Полифенольные соединения, полученные из морских водорослей, как и полифенолы из наземных растений, способны оказывать противовирусное действие.…”

Section: Abstract: Polyphenols Of Terrestrial and Marine Plants; Phlorotannins; Natural Compounds; Inhibitors Of Coronavirus Reproductionunclassified

Polyphenols Sourced from Terrestrial and Marine Plants as Coronavirus Reproduction Inhibitors

Andryukov

Беседнова

Кузнецова

et al. 2021

A&Ch

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The review presents the data of recent years concerning the most important modern problem — the search of the new inhibitors of coronaviruses’ reproduction. Polyphenolic compounds (phlorotannins) from terrestrial and marine plants, polyvalent bioregulators with multiple biological activity, are considered as promising compounds of this type. Polyphenols are able to interfere with different stages of coronaviruses’ life cycle. This fact characterizes polyphenols as multipurpose drugs that affect vital proteins of the pathogens. At the same time, the authors of the review draw attention to the fact that many difficulties must be overcome to develop medications based on plant polyphenols, since these compounds are characterized by complex structures, low bioavailability, as well as rapid excretion from the body. In addition, in vivo studies on animals, as well as in clinical trials, are required. Despite all the difficulties, plant polyphenols should eventually the source for creating antiviral medicines, biologically active food additives, and functional food products.

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“…The increasing demands for new lead compounds in pharmaceutical and agrochemical industries have driven scientists to search for new bioactive natural products in extreme environments (L.S. SANTHI & al [59]).…”

Section: Non-ribosomally Biosynthesized Peptidesmentioning

confidence: 99%

Antimicrobial compounds of the genus Bacillus: A review

Stoica¹,

Moscovici²,

Tomulescu³

et al. 2019

Rom Biotechnol Lett.

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Antibiotics are low molecular-weight molecules produced as secondary metabolites, mainly by microorganisms that live in the soil. Microbial secondary metabolites have been a major source of clinically useful antibiotics. Members of the genus Bacillus are known to produce a wide arsenal of antimicrobial substances, including peptide and lipopeptide antibiotics. These peptides can be classified into two different groups based on whether they are ribosomally (bacteriocins) or nonribosomally (polymyxins and iturins) synthesized. The present paper provides a general overview of antimicrobial peptides derived from Bacillus species, including their structure and classification, as well as several extraction and purification methods used to obtain these bioactive compounds.

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Bioactive Compounds from Marine Sponge Associates: Antibiotics from Bacillus Sp.

Cited by 8 publications

References 23 publications

Antibiofilm activity of symbiotic Bacillus species associated with marine gastropods

Antibiofilm activity of symbiotic Bacillus species associated with marine gastropods

Polyphenols Sourced from Terrestrial and Marine Plants as Coronavirus Reproduction Inhibitors

Antimicrobial compounds of the genus Bacillus: A review

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