Antimicrobial compounds of the genus Bacillus: A review

Stoica, Roxana-Mădălina; Moscovici, Mișu; Tomulescu, Caterina; Casarica, A.; Băbeanu, Narcisa; Popa, Ovidiu; Kahraman, Hatice Ahu

doi:10.25083/rbl/24.6/1111.1119

Cited by 30 publications

(19 citation statements)

References 45 publications

(50 reference statements)

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“…At the same time, members of this family are an important source for producing a wide range of structurally diverse antimicrobial substances with rapid kill activity against various pathogens (Zhao et al, 2018). Antibiotics, which constitute an important part of antimicrobial substances, are mainly produced by microorganisms living in the soil (Stoica et al, 2019). For this purpose, the antimicrobial effect of twenty isolates in the Bacillaceae family isolated from the soil was investigated against various pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Isolation, Molecular Characterization, and Antimicrobial Activity of the Members of the Family Bacillaceae Obtained From Soil Samples

Sevim

Kutalmış²,

Yabaneri³

2022

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The soil is a very rich environment in terms of microorganism diversity and the microorganisms in the soil are the source for many secondary metabolites. Bacteria in the family Bacillaceae are commonly found in the soil and can maintain their vitality for many years because of their spore production. At the same time, the species in this family can produce secondary metabolites which have different functions. In this study, Bacillus or Bacillus-like bacteria were isolated from soil samples in wheat fields and they were identified based on their morphological and molecular features using 16S rRNA gene sequencing. In addition, the antimicrobial activities of the isolates were investigated against various important human pathogens. A total of twenty bacteria were isolated and all of them were identified as Bacillus sp., except for ES-18 which is Lysinibacillus xylanilyticus. Six isolates showed antibacterial activity at different levels and the most effective isolate, ES-18, showed antimicrobial activity against Bacillus cereus, B. megaterium, B. subtilis, Stapyhlococcus aureus, Enterococcus faecalis and Listeria monocytogenes. MIC values of the isolate ES-18 were also determined against the related bacteria and the highest dilution factor was determined to be 2-1. It was also determined that all effective dilutions were bacteriostatic. This is the first study showing antimicrobial properties of L. xylanilyticus and the results obtained from this study might be important for the discovery of new antimicrobial compounds.

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Section: Discussionmentioning

confidence: 99%

Isolation, Molecular Characterization, and Antimicrobial Activity of the Members of the Family Bacillaceae Obtained From Soil Samples

Sevim

Kutalmış²,

Yabaneri³

2022

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“…Their structure confers an amphiphilic character, making them capable of interacting with cell membranes and the vanilloid receptors of the nervous system. [40][41][42] Approximately 25 different natural capsaicinoids have been recorded. 43 Among them, capsaicin and dihydrocapsaicin are considered the major ones, comprising from 89 to 98% of the total CAPS concentration in Capsicum fruits.…”

Section: The Genus Capsicummentioning

confidence: 99%

Perspectives and Applications of Natural Products as Civilian Defense Devices

Antonio¹,

Fonseca²,

Mendes³

et al. 2019

J. Braz. Chem. Soc.

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Civilian defense devices are physical and chemical artefacts used to incapacitate an aggressor without causing death or injury. As city violence increases, safety feelings became worst and a growing commercial demand for these materials supply faces technologically challenges not only to riot control but also to self-protection. Controversies on the use of these devices have been discussed, especially on their toxicity when synthetic chemical agents are used. Natural metabolites are a less explored alternative to meet this demand. They have the capacity to generate a temporary disabling effect due to their pungency. Those metabolites, which include capsaicinoids, gingerols and piperine, can be used as deterrent agents in civilian defense devices due to their low toxicity to humans. Although they are a viable alternative, there are few studies focused on their quality control, efficiency and toxicity. This review aimed to present relevant aspects about the development and use of natural products as deterrent agents in self-defense devices against aggressors and animals, and as non-lethal weapons for riot control in order to help the scientific development of this type of bioproduct. was a member of the CAPES and Brazilian pharmacopoeia committees and has published 143 articles in specialized magazines, 13 patents and 38 book chapters, with 50 thesis and dissertations supervised.

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“…Bacitracin is the first peptide antibiotic derived from cultures of B. licheniformis and has been applied widely in the medical and veterinary area with excellent safety. This antibiotic is a mixture of at least 5 polypeptides, and consists of 3 separate compounds, bacitracin A, B and C. It is active against various species of Gram-positive and a few species of Gram-negative bacteria [ 16 , 17 ]. In addition to that, some strains can produce two-peptide lantibiotic bacteriocin lichenicidin [ 18 ]; however, synthesis of bacteriocin-like peptides such as lichenin and bacillocin was also reported [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Bacillus licheniformis Strains Isolated from Canine Oral Cavity

Hudáková

Kačírová

Sondorová

et al. 2022

Life

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Bacillus licheniformis is used in a broad spectrum of areas, including some probiotic preparations for human and veterinary health. Moreover, B. licheniformis strains are known producers of various bioactive substances with antimicrobial and antibiofilm effects. In searching for new potentially beneficial bacteria for oral health, the inhibitory effect of B. licheniformis strains isolated from canine dental biofilm against pathogenic oral bacteria was evaluated. The antimicrobial effect of neutralized cell-free supernatants (nCFS) was assessed in vitro on polystyrene microtiter plates. Furthermore, molecular and morphological analyses were executed to evaluate the production of bioactive substances. To determine the nature of antimicrobial substance present in nCFS of B. licheniformis A-1-5B-AP, nCFS was exposed to the activity of various enzymes. The nCFS of B. licheniformis A-1-5B-AP significantly (p < 0.0001) reduced the growth of Porphyromonas gulae 3/H, Prevotella intermedia 1/P and Streptococcus mutans ATCC 35668. On the other hand, B. licheniformis A-2-11B-AP only significantly (p < 0.0001) inhibited the growth of P. intermedia 1/P and S. mutans ATCC 35668. However, enzyme-treated nCFS of B. licheniformis A-1-5B-AP did not lose its antimicrobial effect and significantly (p < 0.0001) inhibited the growth of Micrococcus luteus DSM 1790. Further studies are needed for the identification of antimicrobial substances.

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Antimicrobial compounds of the genus Bacillus: A review

Cited by 30 publications

References 45 publications

Isolation, Molecular Characterization, and Antimicrobial Activity of the Members of the Family Bacillaceae Obtained From Soil Samples

Isolation, Molecular Characterization, and Antimicrobial Activity of the Members of the Family Bacillaceae Obtained From Soil Samples

Perspectives and Applications of Natural Products as Civilian Defense Devices

Inhibitory Effect of Bacillus licheniformis Strains Isolated from Canine Oral Cavity

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