Bioactive compounds from marine actinomycetes

Abstract

Actinomycetes are one of the most effi cient groups of secondary metabolite producers and are very important from an industrial point of view. Among its various genera, Streptomyces, Saccharopolyspora, Amycolatopsis, Micromonospora and Actinoplanes are the major producers of commercially important biomolecules. Several species have been isolated and screened from the soil in the past decades. Consequently the chance of isolating a novel actinomycete strain from a terrestrial habitat, which would produce new biologically active metabolites, has reduced. The most relevant reason for discovering novel secondary metabolites is to circumvent the problem of resistant pathogens, which are no longer susceptible to the currently used drugs. Existence of actinomycetes has been reported in the hitherto untapped marine ecosystem. Marine actinomycetes are effi cient producers of new secondary metabolites that show a range of biological activities including antibacterial, antifungal, anticancer, insecticidal and enzyme inhibition. Bioactive compounds from marine actinomycetes possess distinct chemical structures that may form the basis for synthesis of new drugs that could be used to combat resistant pathogens.

GC–MS Analysis of Bio-active Molecules Derived from Paracoccus pantotrophus FMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs

“…The rumen bacterial strain was inoculated in anaerobic basal medium namely Hungate's broth containing the composition (g/L): (KH 2 PO 4 -0.02 g; K 2 HPO 4 -0.03 g; MgSO 4 -0.01 g; CaCl 2 -0.01 g; (NH 4 ) 2 SO 4 -0.1 g; NaCl-0.1 g; Cysteine HCl-0.02 g; NaHCO 3 -0.5 g; resazurin-0.0001 g; cellulose-1.0 g; Trace element-1 ml/l). In addition to that, the medium was supported with 1:4 ratio of cellulose and leather industry solid waste animal flesh and incubated for 9 days at 37°C to achieve the better degradation of animal flesh and thereby the high yield of bioactive compounds.…”

“…Several novel bioactive compounds have also been discovered from aquatic Actinomycetes [4,5]: rifamycin, (Micromonospora sp.) [6]; salinosporamide-A, an anticancer metabolite (Salinispora sp.)…”

In-vitro antimicrobial activity of marine actinobacteria against multidrug resistance Staphylococcus aureus

“…Soil samples were collected at the depth of [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] cm. Samples were collected in sterilized container and transferred to the laboratory and stored in refrigerator at 4曟 until further processing.…”

“…Marine environment covers almost 70% of the earth surface [9] . Organisms present in these environments are extremely rich sources of bioactive compounds [10,11] . The ocean remains as an unexploited source for many drugs and pharmacologically active substances [12] .…”

Coastal biodiversity and bioresources: variation and sustainability

“…Microbial natural products are an important source of both available and novel drugs (Solanki et al, 2008). In Zhang et al (2016), a novel isobenzofuran derivative was isolated from the secondary metabolites of marine Streptomyces sp.…”