Bioactive compounds from
            <i>Cordyceps</i>
            and their therapeutic potential

Krishna, Kondapalli Vamsi; Ulhas, Rutwick Surya; Malaviya, Alok

doi:10.1080/07388551.2023.2231139

Cited by 4 publications

(3 citation statements)

References 159 publications

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“…Although a number of ethenonucleosides have been synthesize and biologically evaluated, − naturally occurring ethenonucleosides are rare. The only precedents are Y-nucleosides, fluorescent ethenoguanosine derivatives found in the anticodon loop of some phenylalanine transfer ribonucleic acids (tRNA Phe ). − Adenosine derivatives are frequently encountered as fungal metabolites, , but 1, N 6 -ethenoadenine-incoporating natural products have not been documented.…”

Section: Resultsmentioning

confidence: 99%

Rogersonins C–F, 9H-Imidazo[2,1-i]purine-Incorporating Adenine-Polyketide Hybrids from an Ophiocordyceps-Associated Clonostachys rogersoniana

Hou,

Wang,

Zhang

et al. 2024

J. Nat. Prod.

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Section: Resultsmentioning

confidence: 99%

Rogersonins C–F, 9H-Imidazo[2,1-i]purine-Incorporating Adenine-Polyketide Hybrids from an Ophiocordyceps-Associated Clonostachys rogersoniana

Hou,

Wang,

Zhang

et al. 2024

J. Nat. Prod.

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“…Cordyceps sinensis is a valuable Chinese medicine with multiple bioactive components and pharmacological effects. 1,2 Several studies have revealed that the extracts of C. sinensis can inhibit tumor cell growth. 3,4 Polysaccharides are the major pharmacologically active compounds of C. sinensis 5,6 and can improve immunity by stimulating immune cell function.…”

Section: Introductionmentioning

confidence: 99%

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Wang,

Chen,

et al. 2024

ACS Appl. Nano Mater.

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Cordyceps sinensis is a valuable Chinese medicine, possessing multiple bioactive compounds with diverse pharmacological effects. The extracts of C. sinensis, especially the polysaccharide fraction, can suppress the proliferation of different tumor cells, induce apoptosis, and stimulate antitumor immune responses. However, C. sinensis polysaccharides (CSP) have yet to be characterized, with a rare reporting of their effective doses. Immunotherapy depends on harnessing the inherent ability of the immune system to recognize and eliminate tumor cells. Polarizing the anti-inflammatory M2 tumor-associated macrophages (TAMs) to the pro-inflammatory M1 phenotype is an effective antitumor immunotherapy strategy. We designed a drug delivery system with black phosphorus (BP) nanosheets loaded with CSP for synergistic antitumor photothermal therapy (PTT) and immunotherapy. The BP/CSP@PDA−PEG-FA nanoparticles (NPs) enhanced the polarization of M2 macrophages to the M1 phenotype in vitro and in vivo. Moreover, the NPs inhibited the growth of 4T1 xenografts upon near-infrared (NIR) laser stimulation by causing photothermal ablation of tumor cells and promoting T cellmediated antitumor immune responses. Therefore, BP/CSP@PDA−PEG-FA NPs are a promising platform for combined PTT and immunotherapy for breast tumors.

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“…Fruiting bodies of C. militaris contain valuable bioactive ingredients such as cordycepin, adenosine, pentostatin, polysaccharides, and digestive enzymes. Therefore, sexual fruiting bodies of this fungus have been widely consumed as edible and medicinal ingredients in Asian countries, including Vietnam [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Effects of MAT1-2 Spore Ratios on Fruiting Body Formation and Degeneration in the Heterothallic Fungus Cordyceps militaris

Vu,

Thai,

Dinh

et al. 2023

JoF

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The medicinal mushroom Cordyceps militaris is widely exploited in traditional medicine and nutraceuticals in Asian countries. However, fruiting body production in C. militaris is facing degeneration through cultivation batches, and the molecular mechanism of this phenomenon remains unclear. This study showed that fruiting body formation in three different C. militaris strains, namely G12, B12, and HQ1, severely declined after three successive culturing generations using the spore isolation method. PCR analyses revealed that these strains exist as heterokaryons and possess both the mating-type loci, MAT1-1 and MAT1-2. Further, monokaryotic isolates carrying MAT1-1 or MAT1-2 were successfully separated from the fruiting bodies of all three heterokaryotic strains. A spore combination of the MAT1-1 monokaryotic isolate and the MAT1-2 monokaryotic isolate promoted fruiting body formation, while the single monokaryotic isolates could not do that themselves. Notably, we found that changes in ratios of the MAT1-2 spores strongly influenced fruiting body formation in these strains. When the ratios of the MAT1-2 spores increased to more than 15 times compared to the MAT1-1 spores, the fruiting body formation decreased sharply. In contrast, when MAT1-1 spores were increased proportionally, fruiting body formation was only slightly reduced. Our study also proposes a new solution to mitigate the degeneration in the heterokaryotic C. militaris strains caused by successive culturing generations.

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Bioactive compounds from Cordyceps and their therapeutic potential

Cited by 4 publications

References 159 publications

Rogersonins C–F, 9H-Imidazo[2,1-i]purine-Incorporating Adenine-Polyketide Hybrids from an Ophiocordyceps-Associated Clonostachys rogersoniana

Rogersonins C–F, 9H-Imidazo[2,1-i]purine-Incorporating Adenine-Polyketide Hybrids from an Ophiocordyceps-Associated Clonostachys rogersoniana

Cordyceps sinensis Polysaccharide Loaded on Black Phosphorus for Synergistic Immunotherapy and Photothermal Therapy of Cancer

Effects of MAT1-2 Spore Ratios on Fruiting Body Formation and Degeneration in the Heterothallic Fungus Cordyceps militaris

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