Bioactive Compounds and Extraction Techniques

Alam, Md. Monjurul; Sarker, Md. Zaidul Islam; Ghafoor, Kashif; Happy, Rukshana Akter; Ferdosh, Sahena

doi:10.1002/9781119168850.ch2

Cited by 11 publications

(8 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As compared to traditional solvent-based extraction methods, MAE, being environmental friendlier, has several advantages such as facile operational conditions, minimal solvent use, non-corrosive solvents, short extraction period, overall low consumption ratio for energy and temperature, and inhibits degradation of thermo-labile compounds [ 69 , 70 ]. Therefore, MAE is widely used in several industrial practices for the extraction of high-value bio-active phenolic compounds, phytonutrients, functional foods, and active pharmaceutical grade constituents from biomaterials [ 47 , 52 , 71 , 72 , 73 ]. Despite the fact that algal biome as a prolific source of bioactive compounds, as discussed above, only a few reports on the use of MAE of compounds such as alkaline galactans, carrageenans, and agar from seaweeds and other algal sources [ 74 , 75 , 76 , 77 , 78 , 79 ].…”

Section: Extraction Methodologies For Bioactive Compoundsmentioning

confidence: 99%

“…EAE of bioactive compounds from numerous sources, including marine ones, has received much attention in recent years. As compared to other reported conventional extraction methods, EAE offers some noteworthy advantages i.e., (1) high selectivity; (2) overall efficacy, (3) rapid extraction, (4) eco-friendly procedures, (5) low-energy consumption, (6) minimal usage of harsh chemicals, (7) maximal yield, (8) low/no wasteful protection/deprotection steps, (9) facile recovery, and (10) process recyclability [ 73 , 91 , 92 , 93 ]. In addition, enzyme-based pre-treatments also help induce mass transfer phenomena and ultimately facilitate the release of bioactive compounds and other secondary metabolites in an efficient manner [ 94 ].…”

Section: Extraction Methodologies For Bioactive Compoundsmentioning

confidence: 99%

“…Enzyme-based pre-treatment or catalysis easily causes the breakdown and/or hydrolysis of complex materials on the cell walls and membranes, thus also supporting the recovery of intracellular bioactive constituents which are not easily extractable through conventional extraction methods. This is because the intracellular bioactive constituents are generally intact and compacted in polysaccharides-lignin chains, which limits their extractability [ 73 ].…”

Section: Extraction Methodologies For Bioactive Compoundsmentioning

confidence: 99%

See 2 more Smart Citations

State-of-the-Art Extraction Methodologies for Bioactive Compounds from Algal Biome to Meet Bio-Economy Challenges and Opportunities

et al. 2018

View full text Add to dashboard Cite

Over the years, significant research efforts have been made to extract bioactive compounds by applying different methodologies for various applications. For instance, the use of bioactive compounds in several commercial sectors such as biomedical, pharmaceutical, cosmeceutical, nutraceutical and chemical industries, has promoted the need of the most suitable and standardized methods to extract these bioactive constituents in a sophisticated and cost-effective manner. In practice, several conventional extraction methods have numerous limitations, e.g., lower efficacy, high energy cost, low yield, etc., thus urges for new state-of-the-art extraction methodologies. Thus, the optimization along with the integration of efficient pretreatment strategies followed by traditional extraction and purification processes, have been the primary goal of current research and development studies. Among different sources, algal biome has been found as a promising and feasible source to extract a broader spectrum of bioactive compounds with point-of-care application potentialities. As evident from the literature, algal bio-products includes biofuels, lipids, polyunsaturated fatty acids, pigments, enzymes, polysaccharides, and proteins. The recovery of products from algal biomass is a matter of constant development and progress. This review covers recent advancements in the extraction methodologies such as enzyme-assisted extraction (EAE), supercritical-fluid extraction (SFE), microwave-assisted extraction (MAE) and pressurized-liquid extraction (PLF) along with their working mechanism for extracting bioactive compounds from algal-based sources to meet bio-economy challenges and opportunities. A particular focus has been given to design characteristics, performance evaluation, and point-of-care applications of different bioactive compounds of microalgae. The previous and recent studies on the anticancer, antibacterial, and antiviral potentialities of algal-based bioactive compounds have also been discussed with particular reference to the mechanism underlying the effects of these active constituents with the related pathways. Towards the end, the information is also given on the possible research gaps, future perspectives and concluding remarks.

show abstract

Section: Extraction Methodologies For Bioactive Compoundsmentioning

confidence: 99%

Section: Extraction Methodologies For Bioactive Compoundsmentioning

confidence: 99%

Section: Extraction Methodologies For Bioactive Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

State-of-the-Art Extraction Methodologies for Bioactive Compounds from Algal Biome to Meet Bio-Economy Challenges and Opportunities

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This is due to the fact that degradation of cell walls and membranes is the critical step of extraction which [101]. Among its advantages over traditional methods are high selectivity, overall efficacy, eco-friendly procedures, low-energy consumption, minimal usage of harsh chemicals, maximum yield, low to no wasteful protection or deprotection steps, easy recovery, and process recyclability [126]. However, it also presents some drawbacks such as the cost of enzymes, requirement of holding tanks that may require long term incubation, lack of knowledge about optimal or compatible enzyme formulations for cell disruption and inability to completely hydrolyse the bonds in plant cell wall [127].…”

Section: Enzyme-assisted Extractionmentioning

confidence: 99%

CapsicumSeeds as a Source of Bioactive Compounds: Biological Properties, Extraction Systems, and Industrial Application

Echave¹,

Pereira²,

Carpena³

et al. 2020

Capsicum

View full text Add to dashboard Cite

Recent research has substantially focused on residual subproducts containing chemical compounds with bioactive properties. Even though there are some culinary or medicinal uses of Capsicum seeds, there is still a seed mass waste from pepper processing. Many pepper leading producer countries generally lack the facilities and infrastructure required for such processing technologies and so, pepper seeds are usually either destroyed or employed as landfilling or as animal feed. This involves an inadvertent economic loss for producers as well as a detrimental environmental impact. However, there is a hidden potential within the pepper processing industry related to valorization of pepper seeds to obtain added value by-products and thus reduce generated waste. Pepper seeds are a good source of antioxidants, carotenoids, phenolic acids, flavonoids, and vitamins C, E, and A and are also rich in volatile compounds, among others. The unique alkaloids of this genus are capsaicinoids and capsainoids, which have been linked to many beneficial biochemical and pharmacological effects including anti-oxidative or anti-inflammatory activities. Other prominent bioactive compounds of peppers seeds include saponins, lectins, and polyunsaturated fatty acids. In this context, an overview of the biological properties, extraction systems, and possible industrial application of bioactive compounds of pepper whole fruit and seeds is presented.

show abstract

“…A range of enzymes including ligninolytic, cellulolytic and proteolytic enzymes has been extensively used as EAE catalysts. Enzyme-based pre-treatment or catalysis easily causes the breakdown and/or hydrolysis of complex materials on the cell walls and membranes, thus also supporting the recovery of intracellular bioactive constituents which are not easily extractable through conventional extraction methods [ 193 ].…”

Section: Novel Liquid–liquid and Solid–liquid Extraction Technologmentioning

confidence: 99%

Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

et al. 2020

View full text Add to dashboard Cite

In the last few decades, attention on new natural antimicrobial compounds has arisen due to a change in consumer preferences and the increase in the number of resistant microorganisms. Macroalgae play a special role in the pursuit of new active molecules as they have been traditionally consumed and are known for their chemical and nutritional composition and their biological properties, including antimicrobial activity. Among the bioactive molecules of algae, proteins and peptides, polysaccharides, polyphenols, polyunsaturated fatty acids and pigments can be highlighted. However, for the complete obtaining and incorporation of these molecules, it is essential to achieve easy, profitable and sustainable recovery of these compounds. For this purpose, novel liquid–liquid and solid–liquid extraction techniques have been studied, such as supercritical, ultrasound, microwave, enzymatic, high pressure, accelerated solvent and intensity pulsed electric fields extraction techniques. Moreover, different applications have been proposed for these compounds, such as preservatives in the food or cosmetic industries, as antibiotics in the pharmaceutical industry, as antibiofilm, antifouling, coating in active packaging, prebiotics or in nanoparticles. This review presents the main antimicrobial potential of macroalgae, their specific bioactive compounds and novel green extraction technologies to efficiently extract them, with emphasis on the antibacterial and antifungal data and their applications.

show abstract

Bioactive Compounds and Extraction Techniques

Cited by 11 publications

References 121 publications

State-of-the-Art Extraction Methodologies for Bioactive Compounds from Algal Biome to Meet Bio-Economy Challenges and Opportunities

State-of-the-Art Extraction Methodologies for Bioactive Compounds from Algal Biome to Meet Bio-Economy Challenges and Opportunities

CapsicumSeeds as a Source of Bioactive Compounds: Biological Properties, Extraction Systems, and Industrial Application

Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications

Contact Info

Product

Resources

About