Bioactive compounds and antioxidant activity of four rose hip species from spontaneous Sicilian flora

Fascella, G.; D’Angiolillo, Francesca; Mammano, Michele Massimo; Amenta, Margherita; Romeo, Flora V.; Rapisarda, Paolo; Ballistreri, Gabriele

doi:10.1016/j.foodchem.2019.02.127

Cited by 79 publications

(91 citation statements)

References 33 publications

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“…In this report, R. canina leaf extracts were compared to three other roses ( R. corymbifera , R. micrantha and R. sempervirens ) and demonstrated to exhibit the highest DPPH radical scavenging ability when harvested in June and the lowest power when collected in October. As reported in a recent study and in contrast to our results with stems, the antioxidant ability of rose hip extracts of R. sempervirens measured by ORAC assay, was significantly more important (4576.77 μmol TE/g DE) than that recorded for R. canina (4493.64 μmol TE/g DE), R. micrantha (3761.11 μmol TE/g DE) and R. corymbifera (2726.68 μmol TE/g DE). When comparing the results of DPPH test in the same report, R. sempervirens hips had the highest radical‐scavenging activity than the three earlier mentioned species ( R. canina , R. micrantha and R. corymbifera ).…”

Section: Resultscontrasting

confidence: 99%

LC‐DAD‐ESI‐MS and HPLC‐DAD phytochemical investigation and in vitro antioxidant assessment of Rosa sp. stem pruning products from different northern areas in Tunisia

Ouerghemmi

Sebeï

Siracusa

et al. 2019

Phytochemical Analysis

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Introduction Rosa species are known by their richness in bioactive compounds useful in cosmetic, perfumery, food and phytotherapy. These metabolites are influenced by several factors accordingly affecting the plant properties in different environments. Objective Exploration of polyphenolic composition and antioxidant activity of stem extracts from Rosa moschata Herrm., R. canina L. and R. sempervirens L. growing in different northern areas in Tunisia. Methods Phytochemical composition was carried out by means of high‐performance liquid chromatography diode‐array detector (HPLC‐DAD) and HPLC‐DAD‐ESI‐MS (electrospray ionisation mass spectrometry). Antioxidant activity was measured using the DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) radical scavenging assay, the FRAP (ferric reducing antioxidant power) test, the TEAC (Trolox equivalent antioxidant capacity) and the ORAC (oxygen radical absorbance capacity) assays. Results Rosa stem profiles were dominated by flavonols but qualitative variation was recorded between sections (Caninae and Synstylae). Aromadendrin‐O‐hexoside‐deoxyhexoside, quercitrin and quercetin 3‐O‐glucoside were identified as the major compounds of R. sempervirens, R. moschata and R. canina, respectively. Quantitative differences were found between species, provenances and extracts either for the individual compounds or for the total phenolic contents. This variability was also highlighted in Rosa scavenger ability results. The highest mean values were recorded by methanolic extracts of R. moschata from Bizerte (TEAC and FRAP) and R. canina for DPPH. However, for ORAC assay, the most active extract was obtained by ethyl acetate from stems of R. canina. Conclusion Results allow concluding that stems of R. sempervirens, R. moschata and R. canina could present a new natural residual source of bioactive phytochemicals, to be employed as additives in pharmaceutical products or in cosmetic and food preparations.

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Section: Resultscontrasting

confidence: 99%

LC‐DAD‐ESI‐MS and HPLC‐DAD phytochemical investigation and in vitro antioxidant assessment of Rosa sp. stem pruning products from different northern areas in Tunisia

Ouerghemmi

Sebeï

Siracusa

et al. 2019

Phytochemical Analysis

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“…Oxidative stress and inflammation are involved in the onset and progression of numerous diseases. Therefore, phytocoumpounds, such as phenols with proven antioxidant ability, are considered health-promoting natural antioxidants [37,38]. Higher production of reactive species can occur secondary to intracellular altered lipid metabolism and accumulation [34].…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea Accessions: Differential Effects on Hepatic Lipid Over-Accumulation

et al. 2020

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Dietary habits are crucially important to prevent the development of lifestyle-associated diseases. Diets supplemented with chickpeas have numerous benefits and are known to improve body fat composition. The present study was undertaken to characterize two genetically and phenotypically distinct accessions, MG_13 and PI358934, selected from a global chickpea collection. Rat hepatoma FaO cells treated with a mixture of free fatty acids (FFAs) (O/P) were used as an in vitro model of hepatic steatosis. In parallel, a high-fat diet (HFD) animal model was also established. In vitro and in vivo studies revealed that both chickpea accessions showed a significant antioxidant ability. However, only MG_13 reduced the lipid over-accumulation in steatotic FaO cells and in the liver of HFD fed mice. Moreover, mice fed with HFD + MG_13 displayed a lower level of glycemia and aspartate aminotransferase (AST) than HFD mice. Interestingly, exposure to MG_13 prevented the phosphorylation of the inflammatory nuclear factor kappa beta (NF-kB) which is upregulated during HFD and known to be linked to obesity. To conclude, the comparison of the two distinct chickpea accessions revealed a beneficial effect only for the MG_13. These findings highlight the importance of studies addressing the functional characterization of chickpea biodiversity and nutraceutical properties.

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“…Anthocyanins have significant free radical-scavenging and antioxidative properties by hydrogen (electron) donation ability belonging to flavonoid molecule (Fascella et al, 2019). They activate the genes responsible for the enzyme production in order to protect DNA by reducing oxidative stress and the formation of endogenous reactive oxygen species.…”

Section: Anthocyaninsmentioning

confidence: 99%

Obesity-associated Pathways of Anthocyanins

et al. 2021

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Anthocyanins have a great potential for human health, as a subgroup of phenolic compounds. Interactions of anthocyanin involved in digestion and thus in obesity consist of inhibition of pancreatic lipase, regulation of lipolysis and lipogenesis, activation of an activated protein kinase enzyme, controlling of digestion hormones (leptin, insulin, ghrelin, cholecystokinin, GIP, GLP-1). Anthocyanins are the compounds that can control metabolic syndrome and obesity by ameliorating lipid metabolism, increasing energy expenditure, suppressing food intake and inhibiting lipid absorption. In addition, the interactions with other compounds during the processing and/or in the intestinal canal can change their absorption capability and bioavailability. Activation of mitogen-activated protein kinase and cyclooxygenase (COX) enzymes, inflammatory cytokines signaling, free-radical scavenging activity are among the primary functions of anthocyanins playing role in the basic metabolic pathways. Anthocyanins also interact with gut microbiota that plays a role in many metabolic pathways. In the review, the effects of anthocyanins on the obesity-associated mechanisms in the metabolism are considered and summarized under the light of recent researches.

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Bioactive compounds and antioxidant activity of four rose hip species from spontaneous Sicilian flora

Cited by 79 publications

References 33 publications

LC‐DAD‐ESI‐MS and HPLC‐DAD phytochemical investigation and in vitro antioxidant assessment of Rosa sp. stem pruning products from different northern areas in Tunisia

LC‐DAD‐ESI‐MS and HPLC‐DAD phytochemical investigation and in vitro antioxidant assessment of Rosa sp. stem pruning products from different northern areas in Tunisia

In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea Accessions: Differential Effects on Hepatic Lipid Over-Accumulation

Obesity-associated Pathways of Anthocyanins

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