Bioactive composition, antimicrobial activities and the influence of Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated functions and biofilm formation by Pseudomonas aeruginosa

Abstract

Agrocybe aegerita (Brig.) Sing is known as a white rot fungus. Antioxidant, antimicrobial activity and antiqourum effect on Pseudomonas aeruginosa of A. aegerita methanolic extract was investigated. The extract showed good antimicrobial activity. Effects of A. aegerita methanolic extract regulated virulence factors in quorum sensing (QS) test, as well as biofilm formation on P. aeruginosa and demonstrated reduction of pyocyanin production, twitching and swimming motility. Methanolic extract exhibited high antioxidant effect. The studied mushroom is a rich source of carbohydrates and proteins. Trehalose was the main free sugar while malic acid was the most abundant organic acid. α-, β-, γ-and δ-Tocopherols were also found, and oleic acid was the most prevalent fatty acid. A. aegerita can be a good source of nutritional and bioactive substances. This research is of great importance due to the prevalence of drug-resistant microorganisms and health-beneficial effects of antioxidants.

Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa

“…It is therefore logical to expect that plants have developed sophisticated chemical mechanisms to combat pathogens. Indeed, mushrooms [29,30] and various plant extracts have been reported as efficient in bacterial QS inhibiting activity [31][32][33]. In this study, as a continuation of our studies on diarylheptanoids from plant sources, we have examined the effect of a series of the seven most common diarylheptanoids from black and green alders using two model bioreporter strains: Pseudomonas aeruginosa PAO1, includ-ing biosensors derived from it, and Chromobacterium violaceum CV026.…”

Nutritional value, chemical composition, antioxidant activity and enrichment of cream cheese with chestnut mushroom Agrocybe aegerita (Brig.) Sing

“…The same behavior was previously reported for other mushroom species. The observed antioxidant activity may be the consequence of the presence of different antioxidant compounds described in the previous section such as tocopherols (mainly α-tocopherol) and organic acids and due to the phenolic acids (Petrovic et al 2014) presented in Agrocybe aegerita. Lo and Cheung (2005) reported antioxidant activity of the methanol crude extract of A. aegerita and its fractions, isolated by liquidliquid partition, using scavenging activity of 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) radical cation (ABTS) and inhibition of lipid peroxidation of rat brain homogenate.…”

Polysaccharides with Antioxidative and Antiaging Activities from Enzymatic‐Extractable Mycelium by Agrocybe aegerita (Brig.) Sing

“…Agrocybe aegerita (Brig.) Sing, belonging to Basidiomycete and called “Yangshugu” in China, is appreciated as an edible and medicinal mushroom among Chinese folk people, which may be due to its traditional antimicrobial effects and improvement of nephritis and edema [15, 16]. Previous studies have indicated that polysaccharides are the most abundant substances in mushrooms and have become an important constituent in the research and development of natural drugs and healthcare products [17].…”