Bioactive Components and Antioxidant Properties of Terminalia arjuna L.Extracts

Chatha, Shahzad Ali Shahid; Hussain, Abdullah Ijaz; Asad, Rehan; Mudasir, Mudasir; Aslam, Nosheen

doi:10.4172/2157-7110.1000298

Cited by 10 publications

(4 citation statements)

References 18 publications

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“…As reported in the literature, the methanolic extract of Garcinia atroviridis (MeGa) containsflavonoid, phenol, saponin, and terpenoid (Nursakinah et al, 2012). A previous study had shown that the concentration of phenolic compounds is correlated with the antioxidant capacity of an extract (Chatha, 2014). Antioxidant capacity is one of the commonly determined parameters for bioactive components with pharmacological activities.…”

Section: Discussionmentioning

confidence: 99%

The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

Lim¹,

NASIR²,

Teh³

et al. 2020

Turk J Biol

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Garcinia species are widely used for their slimming effects via increased fat burning and suppression of satiety. However, scientific evidence for the biological effects of Garcinia atroviridis (GA) is lacking. We investigated the phytochemical composition, safety profiles, and antioxidant and antiobesity effects of methanolic extracts of Garcinia atroviridis (MeGa) in obese female rats. Repeated dose toxicity studies were conducted according to the OECD guidelines. Upon sacrifice, haematological, biochemical, lipid profile, and serum-based metabolomics analyses were performed to evaluate metabolic expression changes and their related pathways. MeGa contains several phytochemical groups and GA fruit acids. MeGa was found to be nontoxic in both male and female rats with an oral lethal dose (LD50) of 2000 mg/kg. After 9 weeks of treatment, MeGa-treated obese rats had lower weight gain and better lipid profiles (cholesterol and triglyceride), which correlated with the altered metabolic pathways involved in the metabolism of lipid (glycerophospholipid) and biosynthesis of unsaturated fatty acid. In addition, MeGa caused differential metabolism pathways of arachidonic acid and tryptophan that affect the inflammatory response and suppression of appetite. We concluded that MeGa is safe, and its slimming effects are due to the differential metabolism of lipids

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Section: Discussionmentioning

confidence: 99%

The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

Lim¹,

NASIR²,

Teh³

et al. 2020

Turk J Biol

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“…To evaluate the antioxidants potential of plant extract the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay was used as described by Shahid et al 22 The percent DPPH inhibition was calculated using the following formula…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Response ofEpimedium gandiflorum’sDifferent Doses to Restore the Antioxidant Potential and Reproductive Hormones in Male Albino Rats

et al. 2020

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Current study was planned to explore the therapeutic response of different doses of hydroethanolic extract of Epimedium grandiflorum leaves in male albino rats. Phytochemical analysis, HPLC and FTIR spectroscopy results revealed the presence of wide range of phenolic compounds and functional groups, respectively. Further, extract not induced significant hemolysis (7.56 ± 1.297%) against PBS (3.65 ± 0.35%) as negative control; while have significant clot lysis (44 ± 5.2%) potential, exhibited DPPH (78.87 ± 5.427%) scavenging, H2O2 (31.82 ± 3.491%) scavenging, antioxidant and reducing power activities. In vivo experimentation in albino male rats’ revealed that administration of different doses (50, 100, 200 mg/Kg b.w.) of extract orally for 42 days after CCl4 intoxication significantly (P < 0.05) restore the selected parameters including liver enzymes, renal profiles, and stress markers and significantly (P < 0.05) increased reproductive hormones like testosterone, luteinizing hormone, follicle stimulating hormone and prolactin while significantly (P < 0.05) decreased progesterone and estradiol toward normal in dose dependent manner. Significant (P < 0.05) improvement in the structural architecture of testicular tissue particularly in high dose group (200 mg/Kg b.w.) was also observed. Results revealed E. grandiflorum has significant therapeutic response to address the healthcare problems particularly of impotency.

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“…The antioxidant, antifungal and antibacterial properties of some species of Terminalia have been reported in the literature [6,7,8,9,10]. The chemical composition (proteins, lipids, carbohydrates, starch and fiber) of T. catappa fruits from Brazil was reported by dos Santos et al [11], and the fatty acid composition of T. catappa kernels from Benin and Thailand was studied by Ladele et al [12] and Weerawatanakorn et al [13].…”

Section: Introductionmentioning

confidence: 99%

Nutritional and Spectral Characteristics of Terminalia Plants

Chakradhari

Rajhans

Patel

et al. 2019

EJMP

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Aims: Terminalia spp. is medicinal plants that belong to Combretaceae family, widely used in traditional Ayurvedic medicine. In this work, the nutritional constituents of the leaves, seed kernel and seed coat from four Terminalia species (T. arjuna, T. bellirica, T. catappa and T. chebula) are reported. Methodology: Polyphenol and flavonoid contents were analyzed spectrophotometrically by using Folin-Ciocalteu and aluminum chloride as reagents, respectively; mineral contents were quantified by using X-ray fluorescence; and the functional groups of the phytochemicals were investigated by infrared spectroscopy. Results: The total concentration of 20 macro- and micronutrients and heavy metals (viz. P, S, Cl, K, Rb, Mg, Ca, Sr, Ba, Al, Ti, Cr, Mn, Fe, Co, Cu, Zn, Mo, As and Pb), and the total polyphenol and flavonoid contents in the seed kernels ranged from 1754 to 65521 mg/kg, from 2150 to 51100 mg/kg and from 63 to 42300 mg/kg, respectively. Polyphenol and mineral contents for the Terminalia spp. seed coats and leaves were also determined. The enrichment in each of aforementioned elements with respect to the soil content was calculated. The vibrational spectra of the leaves and seed coats agreed with a composition rich in lignin, hemicellulose, cutin, pectin and flavonoids, while those of the seed kernels were in accordance with the presence of unsaturated oils, protein, and fiber. Conclusion: Various parts of the four Terminalia species under study (T. arjuna, T. bellirica, T. catappa and T. chebula) featured high contents of nutrients and polyphenols needed for biological metabolism and human health. In addition, heavy metals were only present at traces level, indicating that these Terminalia plants would be safe for medicinal uses.

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Bioactive Components and Antioxidant Properties of Terminalia arjuna L.Extracts

Cited by 10 publications

References 18 publications

The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

Therapeutic Response ofEpimedium gandiflorum’sDifferent Doses to Restore the Antioxidant Potential and Reproductive Hormones in Male Albino Rats

Nutritional and Spectral Characteristics of Terminalia Plants

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