Therapeutic Response ofEpimedium gandiflorum’sDifferent Doses to Restore the Antioxidant Potential and Reproductive Hormones in Male Albino Rats

Abstract

Current study was planned to explore the therapeutic response of different doses of hydroethanolic extract of Epimedium grandiflorum leaves in male albino rats. Phytochemical analysis, HPLC and FTIR spectroscopy results revealed the presence of wide range of phenolic compounds and functional groups, respectively. Further, extract not induced significant hemolysis (7.56 ± 1.297%) against PBS (3.65 ± 0.35%) as negative control; while have significant clot lysis (44 ± 5.2%) potential, exhibited DPPH (78.87 ± 5.427%) scavenging, H2O2 (31.82 ± 3.491%) scavenging, antioxidant and reducing power activities. In vivo experimentation in albino male rats’ revealed that administration of different doses (50, 100, 200 mg/Kg b.w.) of extract orally for 42 days after CCl4 intoxication significantly (P < 0.05) restore the selected parameters including liver enzymes, renal profiles, and stress markers and significantly (P < 0.05) increased reproductive hormones like testosterone, luteinizing hormone, follicle stimulating hormone and prolactin while significantly (P < 0.05) decreased progesterone and estradiol toward normal in dose dependent manner. Significant (P < 0.05) improvement in the structural architecture of testicular tissue particularly in high dose group (200 mg/Kg b.w.) was also observed. Results revealed E. grandiflorum has significant therapeutic response to address the healthcare problems particularly of impotency.

Evaluation of reproductive profile in male albino rats following varied duration of administration with Revive capsule

“…Munir et al also reported an elevated serum testosterone level as a result of orally administrating different doses of the extract of the herb Epimedium gandiflorum. 11 The reports obtained from this study conforms with that of Boepple et al, stating that, an increase in LH and FSH secreted from the anterior pituitary in response to GnRH (secreted from the hypothalamus), results in an increase in the gonadal hormone, testosterone secreted by Leydig cells in testes. 13 There was a significant increase in the mean semen volume after a week of treatment (group B), 3 weeks of treatment (group D) and 6 weeks treatment (group F) when compared to the negative control.…”

“…10 The reports from this study may also be attributed to the individual herbs (containing phytochemicals) used in the formulation of the Revive capsule; Munir et al conducted a study by assessing the therapeutic response of different doses of Epimedium gandiflorum (an herb present in Revive capsule); they reported that oral administration of different doses of the plant's extract induced an increase in serum LH and FSH levels in albino rats pretreated with carbon-tetrachloride. 11 The mean testosterone level of group F was significantly higher when compared to those of the other groups. There was a non-significant increase in groups B (after one week of treatment) and C (after two weeks of treatment) when compared with the negative control (group A).…”

[Retracted] Computer‐Aided Prediction and Identification of Phytochemicals as Potential Drug Candidates against MERS‐CoV

“…Molecular docking is an elaborative method to discover the binding features of different small molecules as drugs against the target proteins [19][20][21]. The natural flora plays a vital role in drug screening and development [22][23][24]. The crude extracts of different medical plants have been reported with biologically active compounds with multiple clinical activities against many diseases [25,26].…”

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

“… 31 Icariin was reported to function as a regulator of adaptive immunity in 1995, 32 and subsequent studies have revealed antihepatotoxic 33 and antioxidant 34 activities as well as the ability to stimulate corticosterone production 35 and promote neurite outgrowth. 36 Icariin has pharmacologic effects on the immune, 37 skeletal 38 and reproductive 39 systems. Over the past few years, an increasing number of studies have focused on the protective effects of icariin in the nervous system diseases.…”