Bioactive Co-Cr alloy for biomedical applications prepared by surface modification using self-assembled monolayers and poly-γ-glutamic acid

Liu, Chao; Matsunami, Chisato; Shirosaki, Yuki; Miyazaki, Toshiki

doi:10.4012/dmj.2015-064

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…To enhance the adhesion between NiTi and the deposited Mg thin film, an extremely thin layer of Cr with a thickness of 5 nm was first deposited on NiTi by sputtering. We selected Cr because it has been not only the most widely used electrically conductive adhesion layer in the field of thin film technology − but also a confirmed biocompatible alloying element as its alloys are widely utilized in clinical applications. , Mg (1 μm thick) was then sputtered on the Cr adhesion layer. Cross-sectional TEM examination of the NiTi–Cr–Mg stent cut with a FIB showed a NiTi–Cr–Mg hierarchical structure in the stent (Figure a, left).…”

Section: Resultsmentioning

confidence: 99%

Interface Engineering of Fully Metallic Stents Enabling Controllable H₂O₂ Generation for Antirestenosis

et al. 2019

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Despite significant advances in the design of metallic materials for bare metal stents (BMSs), restenosis induced by the accumulation of smooth muscle cells (SMCs) has been a major constraint on improving the clinical efficacy of stent implantation. Here, a new strategy for avoiding this issue by utilizing hydrogen peroxide (H 2 O 2 ) generated by the galvanic coupling of nitinol (NiTi) stents and biodegradable magnesium−zinc (Mg−Zn) alloys is reported. The amount of H 2 O 2 released is carefully optimized via the biodegradability engineering of the alloys and by controlling the immersion time to selectively inhibit the proliferation and function of SMCs without harming vascular endothelial cells. Based on demonstrations of its unique capabilities, a fully metallic stent with antirestenotic functionality was successfully fabricated by depositing Mg layers onto commercialized NiTi stents. The introduction of surface engineering to yield a patterned Mg coating ensured the maintenance of a stable interface between Mg and NiTi during the process of NiTi stent expansion, showing high feasibility for clinical application. This new concept of an inert metal/degradable metal hybrid system based on galvanic metal coupling, biodegradability engineering, and surface patterning can serve as a novel way to construct functional and stable BMSs for preventing restenosis.

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Section: Resultsmentioning

confidence: 99%

Interface Engineering of Fully Metallic Stents Enabling Controllable H₂O₂ Generation for Antirestenosis

et al. 2019

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“…The cell attachment activity of CCMs was drastically lower than that of Ti, 6 because the surface of CCM is bioinert. 27,28 The RGDS cell adhesion motif induces integrin-mediated cell adhesion. 29 CCM-RGD peptide bound specifically to 3D-printed CCM and could provide a scaffolding function onto the surface for integrin-mediated cell adhesion.…”

Section: Discussionmentioning

confidence: 99%

Co–Cr–Mo alloy binding peptide as molecular glue for constructing biomedical surfaces

Migita

Sakashita

Saito

et al. 2020

Journal of Applied Biomaterials & Functional Materials

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The mechanical properties of Co–Cr–Mo (CCM) alloys are advantageous in various biomedical applications. However, because of their bioinert surface, CCM alloys exhibit poor endothelial cell attachment properties; thus, problems of biocompatibility remain. In this study, we aimed to improve the biocompatibility of the CCM alloy surface using solid-binding peptides. We selected peptides with high binding affinity for cast CCM alloy surfaces through in vitro evolution by the phage display method. The peptides were functionalized on the CCM alloy surfaces by simple immersion in the peptide solution. The peptide bound to both cast and 3D-printed CCMs with the same affinity. The peptides linked to the amino acid motif that promotes cell adhesion, and improved the attachment of endothelial cells on the 3D-printed CCM in serum and serum-free conditions. Hence, CCM-binding peptides are attractive tools for constructing a biofunctional surface on CCM-based biodevices.

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“…as lithographic masks [139], see figure 46). Energy storage [140][141][142][143] and biomedical applications [144][145][146][147] of SAMs have also been investigated, some of which are discussed further in section 3. [148,149,153,154].…”

Section: 222mentioning

confidence: 99%

Nanoscale self-assembly: concepts, applications and challenges

2022

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Self-assembly offers unique possibilities for fabricating nanostructures, with different morphologies and properties, typically from vapor or liquid phase precursors. Molecular units, nanoparticles, biological molecules and other discrete elements can spontaneously organise or form via interactions at the nanoscale. Currently, nanoscale self-assembly finds applications in a wide variety of areas including carbon nanomaterials and semiconductor nanowires, semiconductor heterojunctions and superlattices, the deposition of quantum dots, drug delivery, such as mRNA-based vaccines, and modern integrated circuits and nanoelectronics, to name a few. Recent advancements in drug delivery, silicon nanoelectronics, lasers and nanotechnology in general, owing to nanoscale self-assembly, coupled with its versatility, simplicity and scalability, have highlighted its importance and potential for fabricating more complex nanostructures with advanced functionalities in the future. This review aims to provide readers with concise information about the basic concepts of nanoscale self-assembly, its applications to date, and future outlook. First, an overview of various self-assembly techniques such as vapour deposition, colloidal growth, molecular self-assembly and directed self-assembly/hybrid approaches are discussed. Applications in diverse fields involving specific examples of nanoscale self-assembly then highlight the state of the art and finally, the future outlook for nanoscale self-assembly and potential for more complex nanomaterial assemblies in the future as technological functionality increases.

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Bioactive Co-Cr alloy for biomedical applications prepared by surface modification using self-assembled monolayers and poly-γ-glutamic acid

Cited by 10 publications

References 28 publications

Interface Engineering of Fully Metallic Stents Enabling Controllable H₂O₂ Generation for Antirestenosis

Interface Engineering of Fully Metallic Stents Enabling Controllable H₂O₂ Generation for Antirestenosis

Co–Cr–Mo alloy binding peptide as molecular glue for constructing biomedical surfaces

Nanoscale self-assembly: concepts, applications and challenges

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Bioactive Co-Cr alloy for biomedical applications prepared by surface modification using self-assembled monolayers and poly-γ-glutamic acid

Cited by 10 publications

References 28 publications

Interface Engineering of Fully Metallic Stents Enabling Controllable H2O2 Generation for Antirestenosis

Interface Engineering of Fully Metallic Stents Enabling Controllable H2O2 Generation for Antirestenosis

Co–Cr–Mo alloy binding peptide as molecular glue for constructing biomedical surfaces

Nanoscale self-assembly: concepts, applications and challenges

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Interface Engineering of Fully Metallic Stents Enabling Controllable H₂O₂ Generation for Antirestenosis

Interface Engineering of Fully Metallic Stents Enabling Controllable H₂O₂ Generation for Antirestenosis