Bioactive behavior of silicon substituted calcium phosphate based bioceramics for bone regeneration

Khan, Ather Farooq; Saleem, Muhammad; Afzal, Adeel; Ali, Asghar; Khan, Afsar; Khan, Abdur Rahman

doi:10.1016/j.msec.2013.11.013

Cited by 123 publications

(50 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is evidence that Si has an anabolic function in bone and connective tissue health. It facilitates bone repair, promotes osteoblast differentiation and collagen synthesis, and provides stability to biological apatite [8,22,[37][38][39][40]. However, the biological effects of Si released from CaP material are not well understood and need to be evaluated experimentally [41].…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

See 1 more Smart Citation

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

View full text Add to dashboard Cite

Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

show abstract

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

“…Substitution of HA with fluoride can inhibit osteoclastic resorption [13], while on Si-substituted sHAs osteoclast activities are enhanced, which e.g. can be demonstrated by production of larger and more numerous resorption lacunae [40,106,107].…”

Section: Degradationmentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

View full text Add to dashboard Cite

show abstract

“…Khan et al [24] presented a comprehensive overview about the role of silicon in enhancing the biological performance and bone forming capabilities of conventional calcium phosphate based bioceramics.…”

Section: Si-substituted Cap Materialsmentioning

confidence: 99%

An overview on biological effects of trace-element in substituted calcium phosphates

Bretaña

Guerra-López

Sena

2017

VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

View full text Add to dashboard Cite

Abstract-Calcium phosphate materials have been widely used as bone substitute due to its good osteointegration. To improve their osteoinductive and osteoconductive properties several element-substitutions in the calcium phosphate matrices have been explored. In the present work, an overview of biological effects of some substitutions in calcium phosphates is done based on an extensive literature revision. Incorporation of elements such as magnesium, fluoride, manganese, zinc, silicon and strontium enhance the bone induction and conduction of calcium phosphate materials. However, this behavior cannot be attributed only to the elements release. The analyzed literature indicated that element substitutions in low concentrations increase the solubility of the calcium phosphate matrices, increasing their bioactivity. Doped materials result osteoinductive and osteoconductive.

show abstract

“…6,7 Silicate-based biomaterials have been reported to enhance vascularization of osteoblastic cells through stimulating the expression of vascular endothelial growth factor (VEGF) from osteoblastic cells or neighbor cells, and it has been widely accepted that angiogenesis could enhance bone formation. [8][9][10] A previous…”

Section: Introductionmentioning

confidence: 99%

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Cao¹,

Weng²,

Chen³

et al. 2017

IJN

View full text Add to dashboard Cite

Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects.

show abstract

Bioactive behavior of silicon substituted calcium phosphate based bioceramics for bone regeneration

Cited by 123 publications

References 107 publications

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

An overview on biological effects of trace-element in substituted calcium phosphates

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Contact Info

Product

Resources

About