Bioactive Asterric Acid Derivatives from the Antarctic Ascomycete Fungus <i>Geomyces</i> sp.

Li, Yan; Sun, Bing-Da; Liu, Shuchun; Jiang, Lihua; Liu, Xingzhong; Zhang, Hua; Che, Yongsheng

doi:10.1021/np8003003

Cited by 66 publications

(34 citation statements)

References 14 publications

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“…2009). Additional metabolites have been isolated from P. pannorum including antimicrobial asterric acid derivatives called “geomycins”, which is active against Aspergillus fumigatus , as well as Gram-positive and Gram-negative bacteria (Li et al 2008). …”

Section: Representative Cold-adapted Fungal Speciesmentioning

confidence: 99%

Living strategy of cold-adapted fungi with the reference to several representative species

et al. 2017

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Our planet is dominant with cold environments that harbour enormously diverse cold-adapted fungi comprising representatives of all phyla. Investigation based on culture-dependent and independent methods has demonstrated that cold-adapted fungi are cosmopolitan and occur in diverse habitants and substrates. They live as saprobes, symbionts, plant and animal parasites and pathogens to perform crucial functions in different ecosystems. Pseudogymnoascus destructans caused bat white-nose syndrome and Ophiocordyceps sinensis as Chinese medicine are the representative species that have significantly ecological and economic significance. Adaptation to cold niches has made this group of fungi a fascinating resource for the discovery of novel enzymes and secondary metabolites for biotechnological and pharmaceutical uses. This review provides the current understanding of living strategy and ecological functions of cold-adapted fungi, with particular emphasis on how those fungi overcome the extreme low temperature and perform their ecological function.

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Section: Representative Cold-adapted Fungal Speciesmentioning

confidence: 99%

Living strategy of cold-adapted fungi with the reference to several representative species

et al. 2017

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“…Geomycin B ( 52 ) showed significant antifungal activity against Aspergillus fumigatus ATCC 10894, with IC 50 /MIC values of 0.86/29.5 μM (the positive control fluconazole showed IC 50 /MIC values of 7.35/163.4 μM). Geomycin C ( 53 ) displayed moderate antimicrobial activities against the Gram-positive bacteria ( Staphylococcus aureus ATCC 6538 and Streptococcus pneumoniae CGMCC 1.1692) and Gram-negative bacterium ( Escherichia coli CGMCC 1.2340) [39]. …”

Section: Microorganismsmentioning

confidence: 99%

Secondary Metabolites from Polar Organisms

Tian

Zhao

2017

Marine Drugs

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Polar organisms have been found to develop unique defences against the extreme environment environment, leading to the biosynthesis of novel molecules with diverse bioactivities. This review covers the 219 novel natural products described since 2001, from the Arctic and the Antarctic microoganisms, lichen, moss and marine faunas. The structures of the new compounds and details of the source organism, along with any relevant biological activities are presented. Where reported, synthetic and biosynthetic studies on the polar metabolites have also been included.

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“…Bioactive, natural products from organisms from the perennially cold and dry climate of Antarctica have shown effective antimicrobial activity (Cavicchioli et al 2002;Zeng et al 2008). For example, bioactive asterric acid derivatives from the Antarctic ascomycete fungus (Li et al 2008), extracts from five Antarctic lichens (Paudel et al 2008), and 22 (3.8%) of 580 bacterial isolates from terrestrial as well as from water column along the Antarctic Terra Nova Bay (Ross Sea) exhibited strong antibacterial activity against a number of Gram-negative and -positive bacterial isolates such as Escherichia coli, Proteus mirabilis, Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis. To our knowledge, no study has been reported on the antimycobacterial activity of pigments from Antarctic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antimycobacterial activity in vitro of pigments isolated from Antarctic bacteria

Mojib

Philpott

Huang

et al. 2010

Antonie van Leeuwenhoek

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In this study, we describe the antimycobacterial activity of two pigments, violacein, a purple violet pigment from Janthinobacterium sp. Ant5-2 (J-PVP), and flexirubin, a yellow-orange pigment from Flavobacterium sp. Ant342 (F-YOP). These pigments were isolated from bacterial strains found in the land-locked freshwater lakes of Schirmacher Oasis, East Antarctica. The minimum inhibitory concentrations (MICs) of these pigments for avirulent and virulent mycobacteria were determined by the microplate Alamar Blue Assay (MABA) and Nitrate Reductase Assay (NRA). Results indicated that the MICs of J-PVP and F-YOP were 8.6 and 3.6 μg/ml for avirulent Mycobacterium smegmatis mc²155; 5 and 2.6 μg/ml for avirulent Mycobacterium tuberculosis mc²6230; and 34.4 and 10.8 μg/ml for virulent M. tuberculosis H₃₇Rv, respectively. J-PVP exhibited a ~15 times lower MIC for Mycobacterium sp. than previously reported for violacein pigment from Chromobacterium violaceum, while the antimycobacterial effect of F-YOP remains undocumented. Our results indicate these pigments isolated from Antarctic bacteria might be valuable lead compounds for new antimycobacterial drugs used for chemotherapy of tuberculosis.

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Bioactive Asterric Acid Derivatives from the Antarctic Ascomycete Fungus Geomyces sp.

Cited by 66 publications

References 14 publications

Living strategy of cold-adapted fungi with the reference to several representative species

Living strategy of cold-adapted fungi with the reference to several representative species

Secondary Metabolites from Polar Organisms

Antimycobacterial activity in vitro of pigments isolated from Antarctic bacteria

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