Antimycobacterial activity in vitro of pigments isolated from Antarctic bacteria

Mojib, Nazia; Philpott, Rachel; Huang, Jonathan P.; Niederweis, Michael; Bej, Asim K.

doi:10.1007/s10482-010-9470-0

Cited by 60 publications

(49 citation statements)

References 46 publications

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“…Additionally these pigments may have clinical significance . Mojib et al, (2010) 15 showed that the pigments extracted from Janthinobacterium sp. and Flavobacterium sp.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the microbial diversity and abundance between the freshwater land-locked lakes of Schirmacher Oasis, and the perennially ice-covered Lake Untersee in East Antarctica

et al. 2010

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Extreme conditions such as low temperature, dryness, and constant UV-radiation in terrestrial Antarctica are limiting factors of the survival of microbial populations. The objective of this study was to investigate the microbial diversity and enumeration between the open water lakes of Schirmacher Oasis and the permanently ice-covered Lake Untersee. The lakes in Schirmacher Oasis possessed abundant and diverse group of microorganisms compared to the Lake Untersee. Furthermore, the microbial diversity between two lakes in Schirmacher Oasis (Lake L27C and L47) was compared by culture-based molecular approach. It was determined that L27Chad a richer microbial diversity representing 5 different phyla and 7 different genera. In contrast L47 consisted of 4 different phyla and 6 different genera. The difference in microbial community could be due to the wide range of pH between L27C (pH 9.1) and L47 (pH 5.7). Most of the microbes isolated from these lakes consisted of adaptive biological pigmentation. Characterization of the microbial community found in the freshwater lakes of East Antarctica is important because it gives a further glimpse into the adaptation and survival strategies found in extreme conditions.

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“…Additionally these pigments may have clinical significance . Mojib et al, (2010) 15 showed that the pigments extracted from Janthinobacterium sp. and Flavobacterium sp.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the microbial diversity and abundance between the freshwater land-locked lakes of Schirmacher Oasis, and the perennially ice-covered Lake Untersee in East Antarctica

et al. 2010

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“…The alamarBlue assays were performed twice in triplicate. The nitrate reductase assay was performed to determine MICs of M. tuberculosis as previously described (36).…”

Section: Methodsmentioning

confidence: 99%

The Mycobacterium tuberculosis Outer Membrane Channel Protein CpnT Confers Susceptibility to Toxic Molecules

Danilchanka

Pires

Anes

et al. 2015

Antimicrob Agents Chemother

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Mycobacterium tuberculosis, the causative agent of tuberculosis, is protected from toxic solutes by an effective outer membrane permeability barrier. Recently, we showed that the outer membrane channel protein CpnT is required for efficient nutrient uptake by M. tuberculosis and Mycobacterium bovis BCG. In this study, we found that the cpnT mutant of M. bovis BCG is more resistant than the wild type to a large number of drugs and antibiotics, including rifampin, ethambutol, clarithromycin, tetracycline, and ampicillin, by 8-to 32-fold. Furthermore, the cpnT mutant of M. bovis BCG was 100-fold more resistant to nitric oxide, a major bactericidal agent required to control M. tuberculosis infections in mice. Thus, CpnT constitutes the first outer membrane susceptibility factor in slow-growing mycobacteria. The dual functions of CpnT in uptake of nutrients and mediating susceptibility to toxic molecules are reflected in macrophage infection experiments: while loss of CpnT was detrimental for M. bovis BCG in macrophages that enable bacterial replication, presumably due to inadequate nutrient uptake, it conferred a survival advantage in macrophages that mount a strong bactericidal response. Importantly, the cpnT gene showed a significantly higher density of nonsynonymous mutations in drug-resistant clinical M. tuberculosis strains, indicating that CpnT is under selective pressure in human tuberculosis and/or during chemotherapy. Our results indicate that the CpnT channel constitutes an outer membrane gateway controlling the influx of nutrients and toxic molecules into slow-growing mycobacteria. This study revealed that reducing protein-mediated outer membrane permeability might constitute a new drug resistance mechanism in slow-growing mycobacteria.

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“…This pigment has the antitumor, antiparasitic, antiprotozoal, anti-cancer, antiviral, antibacterial and furthermore antioxidant activities (12,23,40). The antitumor mechanism of this pigment is still being studied, and it has been recently shown that the mentioned pigment activates the apoptosis in HL60 (leukemia) cell line and p38 MAPK through the activation of caspase-8 and transcription of NF-KB.…”

Section: Violaceinmentioning

confidence: 99%

“…and yellow-orange Flexirubin pigment gained from Flavobacterium sp. were studied by Mojib et al (12,40,42,47).…”

Section: Violaceinmentioning

confidence: 99%

The eminence status of bacterial pigments under different aspects

Sabbagh

Namvar

2017

Microbiol Med

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Several bacteria such as Flavobacterium, Serratias, Chromobacterium and Streptomyces that produce different pigments are playing a significant role in various fields of sciences. Alternatively, current knowledge about bacterial pigments is limited to medical bacteriology, for instance their importance in virulence factors and protective features, however recently the investigators have revealed the supplementary consequence of pigments in food, textile and pharmaceutical aspects.

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Antimycobacterial activity in vitro of pigments isolated from Antarctic bacteria

Cited by 60 publications

References 46 publications

Comparison of the microbial diversity and abundance between the freshwater land-locked lakes of Schirmacher Oasis, and the perennially ice-covered Lake Untersee in East Antarctica

Comparison of the microbial diversity and abundance between the freshwater land-locked lakes of Schirmacher Oasis, and the perennially ice-covered Lake Untersee in East Antarctica

The Mycobacterium tuberculosis Outer Membrane Channel Protein CpnT Confers Susceptibility to Toxic Molecules

The eminence status of bacterial pigments under different aspects

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