Bioactive assessment of bioactive glass nanostructures synthesized using synthetic and natural silica resources

Abstract

The sol‐gel route of synthesizing bioactive glasses of composition 45S5 has shown higher compatibility than the melt casting method. In bioactive glass synthesis, a major silica source is derived from the synthetic tetraethyl orthosilicate precursor. This work demonstrates the sol–gel‐derived bioactive glass prepared from rice husk and TEOS as silica sources. In this study, the effect of crystallization with respect to the silica source in bioactive glass composition was investigated to gain further understanding on the processes involved in the fabrication of bioglass. The in vitro biodegradation and apatite formation of the bioactive glass in simulated body fluid was investigated by spectroscopic and morphological studies. Both the bioactive glasses show a change in morphology toward nanostructured apatite formation after in vitro immersion studies. Further, the hemocompatibility of bioactive glass prepared using rice husk is similar to bioactive glass prepared from organic silica sources. This promises the possibility of synthesizing low cost and biocompatible bioactive glass 45S5 system for tissue engineering applications.

Crucial Chemical Revelations in 45S5 Bioactive Glass via Sequential Precursor Integration Order

“…The supernatant was removed after particular days, and pH was measured using LABMAN LMPH-10. The precipitation was dried at 60 °C for 12 h. 15 The precipitant biomaterials with HCA layer were collected gently, and the structural, morphological, and functional group analysis was carried out. All the samples were experimented in triplicates.…”

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

“…The biologically active ions release, stimulates specific healing mechanisms in soft tissue repair and wound healing [119], thus causes specific biological effects. BGs are amorphous in origin and have intermediate oxides, network modifiers, and network formers, in their framework [120]. Without external materials, the network designers could shape glasses independently [121].…”

Sustainable Development of a Bioactive Material from Recycled Rice Husk and Eggshell for Bone Regeneration Application

“…transforming them into value-added products . Among them, recycling biowaste like rice husk (600 million tons per annum) and eggshell (78 million metric tons per annum) is a great challenge yet to be addressed satisfactorily, although attempts have been made to use them as fodder, fertilizer, and some other value-added products. , However, considering the demand for an artificial bone graft material (2.2 million worldwide annually) for treating bone-related problems, and the availability of rice husk and eggshell contain a high percentage of silica and calcium, respectively, serve to be a good alternative and a sustainable source of the precursors. − Thus, researchers opted for the synthesis of BM from rice husk and eggshell as a source of silica and calcium, − however, relying on the use of acids, binders, and higher processing temperatures (∼1400 °C), which serves to be the limitations from sustainability perspectives. Thus, with this motivation and comprehensive understanding, herein, we report the eco-friendly and cost-effective synthesis of 70S30C CS by a simple precipitation method using recycled rice husk and eggshell biowaste as a source of silica and calcium.…”