Bioactive Applications for Electrospun Fibers

Quirós, Jennifer; Boltes, Karina; Rosal, Roberto

doi:10.1080/15583724.2015.1136641

Cited by 62 publications

(37 citation statements)

References 158 publications

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“…However, PCL as the matrix has limited applicability in biomedical practices because it cannot solely used to regenerate bone tissues due to the minimal stiffness, hydrophobicity and marginal bioactivity. Nonetheless, the use of bioactive materials together with PCL for the preparation of the electrospun mats has received great attention for novel development of membranes with superb cell proliferation and wound dressing [31][32][33][34]. For example, Correia and co-workers [35] investigated the use of extracted aloe vera chitosan nanofibrous materials and the subsequent fabrication using electrospinning method in the application of skin recovery and wound healing.…”

Section: Electrospun Nanoparticlesmentioning

confidence: 99%

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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Polycaprolactone (PCL) is one of the most used synthetic polymers for medical applications due to its biocompatibility and slow biodegradation character. Combining the inherent properties of the PCL matrix with the characteristic of nanofibrous particles, result into promising materials that can be suitable for different applications, including the biomedical applications. The advantages of nanofibrous structures include large surface area, a small diameter of pores and a high porosity, which make them of great interest in different applications. Electrospinning, as technique, has been heavily used for the preparation of nano- and micro-sized fibers. This review discusses the different methods for the electrospinning of PCL and its composites for advanced applications. Furthermore, the steady state conditions as well as the effect of the electrospinning parameters on the resultant morphology of the electrospun fiber are also reported.

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Section: Electrospun Nanoparticlesmentioning

confidence: 99%

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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“…23 Due to these unique properties electrospun bres have been proposed for uses in several biomedical applications including scaffolds for tissue engineering, medical implants, biosensors, and wound dressings. 24,25 The functionalization of electrospun dressings with active substances has recently become an active research topic. Electrospun brous scaffolds benet from their inherently small pores to inhibit microbial invasions and to control uid drainage.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of antimicrobial peptides on electrospun nanofibres for biomedical applications

et al. 2018

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“…It has been shown that chitosan (CS) has wide application in biomedical and pharmacology because of its non-toxicity and unique biological and physiochemical properties as well as antimicrobial activity. Indeed, linoleic acid (LA) comprised of Trans-11 and Cis-9 is one of the appropriate acids that inhibits fungal cell growth (26,27).…”

Section: Discussionmentioning

confidence: 99%

Novel Formulated Zinc Oxide Nanoparticles Reduce Hwp1 Gene Expression Involved in Biofilm Formation in Candida albicans with Minimum Cytotoxicity Effect on Human Cells

Aslani

Mohammadi

Roudbary

2018

Jundishapur J Microbiol

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Background: Drug resistance in Candida species, has emerged as a major problem in the public health system worldwide. Application of nanoparticles is proposed as a novel and potential agent for reduction of drug resistance burdens. Objectives: The current study was conducted to evaluate the effects of zinc oxide nanoparticles (ZnO NPs containing chitosan and linoleic acid) on hyphae cell wall proteins (Hwp1) gene expression, a crucial gene in pathogenicity of Candida albicans, and cytotoxicity on human hepatocyte carcinoma (HepG2) cells as well as the production of Reactive Oxygen Species (ROS). Methods: The effects of novel ZnO NPs on expression of Hwp1 gene of C. albicans was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) in comparison to fluconazole as a standard drug. Reactive Oxygen species production was examined in macrophages treated with ZnO NPs relative to non-treated cells. Also, the cytotoxicity effects of ZnO NPs were assessed using the MTT assay against HepG2 cell line. Results: The findings indicated that ZnO NPs significantly decreased the level of Hwp1 gene expression in standard and clinical isolates of C. albicans. Increased level of ROS production in macrophages was found in the presence of ZnO NPs in concentrationdependent manner compared to the control group without exposure of ZnO NPs (P = 0.001). Furthermore, ZnO NPs did not show cytotoxicity activity on HepG2 cells at different concentrations (P > 0.05). Conclusions: Taken together, the newly synthesized ZnO NPs may be a suitable candidate for inhibition of the critical gene responsible for biofilm dispersion and the control of Candida infection with limited cytotoxicity on human cells. However, more studies are required for support of its effect in vitro and in vivo.

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Bioactive Applications for Electrospun Fibers

Cited by 62 publications

References 158 publications

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

Incorporation of antimicrobial peptides on electrospun nanofibres for biomedical applications

Novel Formulated Zinc Oxide Nanoparticles Reduce Hwp1 Gene Expression Involved in Biofilm Formation in Candida albicans with Minimum Cytotoxicity Effect on Human Cells

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