Bioactive alkaloids from the aerial parts of Houttuynia cordata

Ma, Qinge; Wei, Rongrui; Wang, Zhiqiang; Liu, Wenmin; Sang, Zhipei; Li, Yaping; Huang, Hong Hai

doi:10.1016/j.jep.2016.11.013

Cited by 47 publications

(29 citation statements)

References 34 publications

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“…6 In the past few decades, researchers have isolated many kinds of phytochemicals from the plant, such as essential oils and flavonoids that possess diuretic, antiviral, anti-inflammatory and anticancer properties 1,2,[7][8][9] and alkaloids that are cytotoxic to human cancer cell lines. 10,11 Of all the alkaloids present in H. cordata, aristolactams (ALs) are recently of concern in Chinese society because of the similar Chinese names for ALs (Ma'dou'ling'nei'xian'an) and aristolochic acids (Ma'dou'ling'suan; AAs), of which the latter cause a rapidly progressive kidney fibrotic disease known as aristolochic acid nephropathy (AAN). 12,13 As a result, people are now worried about the risk of developing AAN through H. cordata intake.…”

Section: Introductionmentioning

confidence: 99%

“…Besides culinary use, H. cordata has been recorded in the Chinese Pharmacopoeia as an herbal medicine for treating lung carbuncles, dysentery, inflammation, and various other disorders 6 . In the past few decades, researchers have isolated many kinds of phytochemicals from the plant, such as essential oils and flavonoids that possess diuretic, antiviral, anti‐inflammatory and anticancer properties 1,2,7–9 and alkaloids that are cytotoxic to human cancer cell lines 10,11 …”

Section: Introductionmentioning

confidence: 99%

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Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry

2020

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Houttuynia cordata (H. cordata) is a popular vegetable in Asian countries and is also used extensively as herbal medicine in treating various diseases. H. cordata contains aristolactams, which have a similar Chinese name as aristolochic acids (AAs); hence, an emerging concern in the greater China region has arisen about the potential linkage between H. cordata and aristolochic acid nephropathy (AAN). However, only a single study has tested for the presence of AAs in H. cordata samples, and the analysis was limited by the analytical sensitivity of the method. Thus, further analysis of AAs in H. cordata using analytical method of higher sensitivity is needed to alleviate public anxiety over the use of this popular vegetable. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used to analyze H. cordata samples for the natural existence of aristolochic acid I (AA-I) and aristolochic acid II (AA-II), which are the most carcinogenic and nephrotoxic compounds in the AA family. After evaluating the method performance by fortifying blank samples with three concentrations of AAs, the validated method was applied to identify AA-I and AA-II in both fresh and sun-dried H. cordata samples (n = 20) collected from different cities in China. The LC-MS/MS method achieved method detection limits (MDLs) as low as 2 ng/g of AAs in H. cordata. Analysis of the collected fresh and sun-dried H. cordata samples revealed that AA-I and AA-II either do not exist naturally in H. cordata or exist at concentrations below the MDLs. Therefore, it is not very likely that consumption of H. cordata will result in AAN because AA-I and AA-II, the nephrotoxic and carcinogenic culprits of AAN, are not produced naturally in the plant or are produced at levels that do not pose a risk of AAN.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry

2020

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“…The ethyl acetate extract of H. cordata (EAEH) has been reported for antiviral property against dengue virus and mouse hepatitis virus [28]. The EAEH exhibited hepatoprotective activity, inhibited the hydroxyl and alkyl free radicals in vitro, and prohibited the carbon tetrachloride-induced liver damage in mice [29], and the isolated alkaloids of H. cordata showed moderate hepatoprotective activity in d-galactosamine-induced WB-F344 cells, and anti-inflammatory activity [30,31].…”

Section: Resultsmentioning

confidence: 99%

Assessment of Subchronic Toxicity of Fermented Houttuynia Cordata Thunb. Using Rodent Model System

Chaiyasut

Sivamaruthi

Duangjitcharoen

et al. 2018

Asian J Pharm Clin Res

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Objective: The present study was intended to evaluate the subchronic toxicity of Lactobacillus-mediated fermented Houttuynia cordata juice (FHJ) using rodent model system. Methods:FHJ was prepared and the microbial load, lactic acid content, and pH was estimated. Rats were fed with different doses of FHJ for 60 days. The body mass changes were measured during FHJ supplementation. After the treatment period, blood and organs of the experimental rats were collected. The samples were subjected to hematological and biochemical analysis by following standard hospital protocols. Results:The pH of FHJ after 30 days of fermentation was 3.63. The lactic acid content of FHJ was gradually increased and reached 19.70 mg per mL after 30 days of the fermentation process. Lactobacillus load was high in FHJ after 30 days and no Bacillus spp. and yeast were detected in FHJ at any point of fermentation. There were no significant changes in body weight of male and female experimental rats supplemented with FHJ, irrespective of dose. There were no significant treatment-related pathological changes found in any organ of the experimental rats at all tested dose levels when compared with organs in control animals. There were no significant changes observed in red blood cells (RBCs), white blood cells (WBCs), hemoglobin, hematocrits, lymphocyte, and platelets level of male rats of all groups. Whereas, significant (p<0.01) changes were observed in the RBC (1.02±0.26 106/mm 3 ) of female rats in effective dose (ED) group compared to control. Similarly, significant (p<0.01) changes were detected in the WBC level of female rats in high dose (−7.53±0.03 103/mm3), and post-ED group (−8.86±0.75 103/mm 3 ) compared to control. There were no alterations in tested biochemical parameters of experimental rats. Conclusion:The FHJ was rich in probiotic Lactobacillus. The supplementation of FHJ (9 mL/kg/day) for 60 days did not significantly affect the body mass, internal organs, hematological, and biochemical parameters of rats. The results suggested that FHJ is qualified for the human consumption.

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“…The main component of fresh Herba houttuyniae is water, and no major components account for large proportions of the dried weight of Herba houttuyniae [28]. A few isolated phytochemicals of Herba houttuyniae, including houttuynia sodium, flavonoids, and alkaloids, have been identified as having biological activity [38][39][40], while their presence in only small amounts in Herba houttuyniae restricts further exploration. Moreover, evidence has shown that the water extract of Herba houttuyniae exhibits superior biological activity [41].…”

Section: Discussionmentioning

confidence: 99%

Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade

Cao

Liu

et al. 2020

Nutrients

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Hyperlipidemia is associated with metabolic disorders, but the detailed mechanisms and related interventions remain largely unclear. As a functional food in Asian diets, Herba houttuyniae has been reported to have beneficial effects on health. The present research was to investigate the protective effects of Herba houttuyniae aqueous extract (HAE) on hyperlipidemia-induced liver and heart impairments and its potential mechanisms. Male C57BL/6J mice were administered with 200 or 400 mg/kg/day HAE for 9 days, followed by intraperitoneal injection with 0.5 g/kg poloxamer 407 to induce acute hyperlipidemia. HAE treatment significantly attenuated excessive serum lipids and tissue damage markers, prevented hepatic lipid deposition, improved cardiac remodeling, and ameliorated hepatic and cardiac oxidative stress induced by hyperlipidemia. More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which may be attributable to the loss of adenosine monophosphate (AMP)-activated protein kinase (AMPK) activity: all of these changes were reversed by HAE supplementation. Our findings link the AMPK/PGC-1α/Nrf2 cascade to hyperlipidemia-induced liver and heart impairments and demonstrate the protective effect of HAE as an AMPK activator in the prevention of hyperlipidemia-related diseases.

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Bioactive alkaloids from the aerial parts of Houttuynia cordata

Cited by 47 publications

References 34 publications

Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry

Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry

Assessment of Subchronic Toxicity of Fermented Houttuynia Cordata Thunb. Using Rodent Model System

Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade

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