Bioactivation of Phytoestrogens: Intestinal Bacteria and Health

Landete, José María; Arqués, Juan Luís; Médina, Margarita; Gaya, Pilar; Rivas, Blanca de las; Múñoz, Rosario

doi:10.1080/10408398.2013.789823

Cited by 163 publications

(127 citation statements)

References 171 publications

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“…There are a wide variety of polyphenols but, in general, they have been classiied into two groups according to their chemicals properties: lavonoids and non-lavonoids (Figure 1). The types of phytoestrogens are isolavones, lignans, coumestans, ellagitannins and stilbens [13][14][15]. Figure 3 shows the main sources of phytoestrogens and the phytochemicals with estrogenic properties.…”

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

“…Figure 3 shows the main sources of phytoestrogens and the phytochemicals with estrogenic properties. The primary sources of lignans are laxseed, whole grain cereal and some beverages, such as cofee, tea and wine [15]. For isolavones are legumens such as soybeans and peanuts, chickpeas and kudzu, lupine, fava, alfalfa, peanuts and chickpeas [15].…”

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

“…The primary sources of lignans are laxseed, whole grain cereal and some beverages, such as cofee, tea and wine [15]. For isolavones are legumens such as soybeans and peanuts, chickpeas and kudzu, lupine, fava, alfalfa, peanuts and chickpeas [15]. In the case of clover alfalfa and soybean sprouts, these are sources of coumestans [13].…”

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

“…Ellagitannins are abundant in fruits, nuts and seeds such as pomegranate, black raspberries, strawberries, walnuts and almonds [16]. The main source of stilbens such as revestratrol is the red wine and peanuts [15].…”

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

“…Furthermore, it is proposed that the biotransformation of isolavones, ellagitannins and lignans by intestinal microbiota is essential in protection against menopausal symptoms. Also against certain chronic diseases, such as cancer, cardiovascular disease and osteoporosis [15], suggesting that the main discrepancies between a successful treatment versus lack of efect could be explained by the low bioavailability of phytoestrogens [21].…”

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

See 4 more Smart Citations

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Estrada‐Camarena¹,

López‐Rubalcava²,

Sustaita³

et al. 2017

A Multidisciplinary Look at Menopause

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Menopause transition is recognized as a vulnerable period in women life to develop or aggravate symptoms of psychiatric disorders. Several treatments including antidepressants and hormonal restitution with estrogens have been suggested to ameliorate the symptoms. Also, in this period of life is frequent the use of other drugs to treat is also frequent the use of other drugs to treat comorbid pathologies that might even increase the risk of drug-drug interactions. Literature reports that some phytochemicals with estrogenic activity have beneicial efects during menopausal transition without collateral events. This chapter shows evidence about the use of phytoestrogens as an alternative therapy for the treatment of some psychiatric symptoms associated with the menopausal transition. Data derived from preclinical research related to the use of classical phytoestrogens (isolavones), considering the beneicial efects, as well as adverse events, are discussed. Also, the use of polyphenols and organosulfurate compounds as an alternative for the treatment of anxiety-and depressive-like behavior as well as ibromyalgia is included. A narrative review was conducted using bibliography reporting the use of isolavones (genistein, daidzein, equol), coumestans or lignans for the reduction of depressive-like or anxiety-like behavior. Furthermore, it is described if the use of this compounds impact in other signs of menopause, i.e. vasomotor and osteoporosis. In addition, due to the high frequency of comorbid pathologies as diabetes mellitus, dyslipidemia or metabolic syndrome with psychiatric disorders, the use of these phytochemicals is discussed.

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Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

Section: Phytochemicals: Polyphenolsmentioning

confidence: 99%

See 3 more Smart Citations

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Estrada‐Camarena¹,

López‐Rubalcava²,

Sustaita³

et al. 2017

A Multidisciplinary Look at Menopause

View full text Add to dashboard Cite

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Nanoparticles in Nondairy Yogurt Formulation Techniques for Amelioration of Lifestyle Disorder Diseases

Bhattacharya¹,

Akter²,

Rahman³

2022

Nanotechnology in Functional Foods

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Flavone, flavanone and flavonol metabolism from soybean and flaxseed extracts by the intestinal microbiota of adults and infants

Landete

2021

J Sci Food Agric

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BACKGROUND: Flaxseed and soybean are an important source of lignans and flavonoids. Previously, the metabolism of isoflavones and lignans from soybean and flaxseed extracts by the microbiota of adult individuals (n = 14) and infants (n = 23) was analyzed. Thus, the present study aimed to examine the metabolism of flavones, flavanones and flavonols, as well as the production of phenolic acids, by the intestinal microbiota of these individuals.RESULTS: Concentrations of aglycones of flavonoids, such as herbacetin, quercetin, quercetagetin, myricetin, kaempferol, apigenin and luteolin, increased for most of individuals as a consequence of deglycosylation reactions. On the other hand, a diminution in the antioxidant activity and phenolic compound concentration and an increase in the concentration of 3,4-dihydroxyphenylacetic acid, 2-(4-hydroxyphenyl)-propionic acid, protocatechuic acid and catechol was also observed.CONCLUSION: The present study found that deglycosylation reactions were the main reactions and accelerated the formation of more bioavailable flavonoids, with greater biological activity, in most of the individuals. However, other reactions also occurred, including the total or partial catabolism of flavonoids.

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Bioactivation of Phytoestrogens: Intestinal Bacteria and Health

Cited by 163 publications

References 171 publications

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Nanoparticles in Nondairy Yogurt Formulation Techniques for Amelioration of Lifestyle Disorder Diseases

Flavone, flavanone and flavonol metabolism from soybean and flaxseed extracts by the intestinal microbiota of adults and infants

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