Bioaccumulations of aluminum and the effects of chelating agents on different organs of Cirrhinus mrigala

Sivakumar, S.; Khatiwada, Chandra Prasad; Sivasubramanian, J.

doi:10.1016/j.etap.2012.09.007

Cited by 25 publications

(19 citation statements)

References 16 publications

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“…There are indicated studies that the potential role of chelators in preventing or reducing the toxic effects of heavy metals depending on the origin of the chelators (natural or synthetic), metals, concentrations, exposure periods, test materials and environmental factors such as hardness, pH (Batchelder et al, 1980;Hung, 1982;Hansten et al, 1996;Gopal et al, 2009;Palaniappan et al, 2009;Sivakumar et al, 2012). It has been reported that humic acid decreases Cd and Cu toxicity while increases Zn toxicity, EDTA and Fe decrease in toxicity of all three metals, Mn increases Zn toxicity but without any effect on Cd and Cu toxicity in Anodonta anatina (Hansten et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Effects of Clinoptilolite on Copper Accumulation of Oreochromis niloticus

Çiftçi¹,

Karayakar²,

Cıcık³

2018

Natural and Engineering Sciences

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The copper accumulation in liver and gill tissues of Oreochromis niloticus, exposed to 2 ppm Cu and 1g/L clinoptilolite singly and to the same concentrations of their mixture over 24, 48, 72 and 96 hours was studied. ICP-AES spectrophotometer techniques were applied in determining tissue copper levels. Statistical evaluation of the experimental data was carried out by Student Newman Keul's procedure. No mortality was observed during the experiments. Copper accumulation was lower in metal-clinoptilolite mixture group than metal singly group in gill tissue while no accumulation in both experimental groups in liver tissue (P<0.05). In addition, the copper level in the liver was lower in all experimental groups than in the control (P<0.05). Low Cu accumulation in gill tissue exposed in mixture groups can be explained by copper adsorption with chelating agent. The decrease of Cu reserves in the liver can be expressed by increase of copper-containing enzyme and protein synthesis.

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Section: Discussionmentioning

confidence: 99%

Effects of Clinoptilolite on Copper Accumulation of Oreochromis niloticus

Çiftçi¹,

Karayakar²,

Cıcık³

2018

Natural and Engineering Sciences

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“…Aluminum (Al) is a ubiquitous environmental metal toxicant [1]. Al exposure can cause toxic effects on the nervous system, bone, reproductive system, and liver, especially in the immune system [2].…”

Section: Introductionmentioning

confidence: 99%

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Yang

Zhuang

et al. 2016

Biol Trace Elem Res

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Aluminum (Al) exposure is toxic to immune system. Studies have implicated that glucocorticoids (GCs) exert the dual regulation effect on the immune function depending on the concentration. However, it is unknown whether a dual effect of GCs exists in the AlCl3-treated lymphocytes. Corticosterone (Cort) is one kind of GCs. To investigate the effect of different concentration Cort on AlCl3-treated lymphocytes, rat splenic lymphocyte was isolated and cultured with 0.55 mmol/L AlCl3, simultaneously administrated Cort at final concentration of 0 (control group, CG), 10(-8) (low-level group, LG), and 10(-6) (high-level group, HG) mol/L, respectively. Another group without AlCl3 and Cort served as the blank group (BG). We found that low concentration Cort increased the T and B lymphocyte proliferation rate, proportions of CD4(+) T lymphocyte subset, IgG, IL-2, and TNF-α contents, whereas high concentration Cort decreased those in AlCl3-treated lymphocytes. In conclusion, the results of this study indicated that low concentration Cort relieves the immunotoxicity of AlCl3 on the splenic lymphocytes, whereas high concentration Cort aggravates it.

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“…Al exposure is thus closely associated with neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and dialysis encephalopathy [6]. The liver plays a significant role in contaminant storage, redistribution, and detoxification [7]. It is an important early sink for absorbed Al, and Al can be excreted through bile and finally through feces to the outside of body [8, 9], so some researches have also focused on the adverse effects of Al on the liver.…”

Section: Introductionmentioning

confidence: 99%

The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

Tian

Zhai

et al. 2017

PLoS ONE

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Our previous study found that Lactobacillus plantarum CCFM639 had the ability to alleviate acute aluminum (Al) toxicity when the strain was introduced simultaneously with Al exposure. This research was designed to elucidate the therapeutic effects of living and dead L. plantarum CCFM639 against chronic Al toxicity and to gain insight into the protection modes of this strain. Animals were assigned into control, Al only, Al + living CCFM639, and Al + dead CCFM639 groups. The Al exposure model was established by drinking water for the first 4 weeks. The strain was given after Al exposure by oral gavage at 109 colony-forming units once per day for 12 weeks. The results show that the Al binding ability of dead CCFM639 was similar to that of living CCFM639 in vitro. The ingestion of living or dead CCFM639 has similar effects on levels of Al and trace element in tissues, but living strains led to more significant amelioration of oxidative stress and improvement of memory deficits in Al-exposed mice. In conclusion, in addition to intestinal Al sequestration, CCFM639 treatment offers direct protection against chronic Al toxicity by alleviation of oxidative stress. Therefore, L. plantarum CCFM639 has a potential as dietary supplement ingredient that provides protection against Al-induced injury.

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Bioaccumulations of aluminum and the effects of chelating agents on different organs of Cirrhinus mrigala

Cited by 25 publications

References 16 publications

Effects of Clinoptilolite on Copper Accumulation of Oreochromis niloticus

Effects of Clinoptilolite on Copper Accumulation of Oreochromis niloticus

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

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