Bioaccumulation, tissue distribution, and maternal transfer of novel PFOS alternatives (6:2 Cl-PFESA and OBS) in wild freshwater fish from Poyang Lake, China

Concentrations of 45 Per- and Polyfluoroalkyl Substances in North American River Otters (Lontra canadensis) from West Virginia, USA

“…Indeed, the pancreas had the third highest concentrations of total PFAS, next to the liver and bile. The median concentrations of PFOS in river otter pancreas were 1–2 orders of magnitude higher than those reported for fish from China (median: 2.4–32 ng/g ww) . In addition, the TLRs of PFPeS (1.87) and N-EtFOSAA (1.46) were the highest in the pancreas (Figure ), indicating their preferential accumulation in this organ.…”

“…Exposure to PFAS has been linked to metabolic disorders, potentially through the disruption of pancreatic function . Very few studies have measured PFAS in the pancreas . We found 22 out of 45 PFAS in the river otter pancreas, with a median concentration of ∑All at 204 ng/g ww (Figure S1).…”

“…continued China (median: 2.4−32 ng/g ww). 43 In addition, the TLRs of PFPeS (1.87) and N-EtFOSAA (1.46) were the highest in the pancreas (Figure 3), indicating their preferential accumulation in this organ. PFAS were also detected in two placenta samples collected from pregnant river otters (Table S8), suggesting transplacental transfer of PFAS.…”

“…42 Very few studies have measured PFAS in the pancreas. 43 We found 22 out of 45 PFAS in the river otter pancreas, with a median concentration of ∑All at 204 ng/g ww (Figure S1). Indeed, the pancreas had the third highest concentrations of total PFAS, next to the liver and bile.…”