Bioaccumulation of super‐lipophilic chemicals in fish

Bruggeman, W. A.; Opperhuizen, Antoon; Wijbenga, A.; Hutzinger, O.

doi:10.1080/02772248409357024

Cited by 225 publications

(118 citation statements)

References 25 publications

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“…Chlorinated alkane concentrations were corrected for growth dilution and lipid-normalized for all bioaccumulation parameters. Assimilation efficiencies (␣) were calculated by fitting the concentration data to the integrated form of the kinetic rate equation for constant dietary exposure [23] using iterative nonlinear regression:…”

Section: Discussionmentioning

confidence: 99%

Dietary accumulation of C₁₂‐ and C₁₆‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)

Fisk

Bergman

Cymbalisty

et al. 1996

Enviro Toxic and Chemistry

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Abstract-DietaryC analysis of fish tissue extracts revealed that the chlorinated alkane mixtures were selectively biotransformed with certain unknown components persisting in tissues. Lower chlorinated alkanes had greater proportions of polar 14 C, which implies greater metabolism of these compounds. Highly chlorinated, short-carbon-chain (C 10-13 ) alkanes and lower chlorinated, medium-carbon-chain (C 14-18 ) alkanes appear to have the greatest potential for biomagnification among CP components. No reduced growth rates or hepatic monooxygenase enzyme induction were seen in any of the chlorinated alkane exposures when compared with controls.

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Section: Discussionmentioning

confidence: 99%

Dietary accumulation of C₁₂‐ and C₁₆‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)

Fisk

Bergman

Cymbalisty

et al. 1996

Enviro Toxic and Chemistry

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show abstract

“…Several authors have reported such ''parabolic'' relationships between log concentration factor (CF) (calculated against total water concentrations) and log K ow in aquatic organisms [28][29][30][31]. This phenomenon implies that the CFs of organic contaminants with log K ow values exceeding about 6 are lower than what is expected from a linear relationship, which is predicted from equilibrium partitioning [32].…”

Section: Bioaccumulation Factors Versus K Owmentioning

confidence: 90%

Enhanced accumulation of PCB congeners by baltic sea blue mussels, Mytilus edulis, with increased algae enrichment

Gilek¹,

Björk²,

Broman³

et al. 1996

Enviro Toxic and Chemistry

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Abstract-The objective of this study was to examine if natural variations in the quantity of phytoplankton-derived particulate and dissolved organic carbon influences the accumulation of polychlorinated biphenyls (PCBs) in the tissues of Baltic Sea blue mussels (Mytilus edulis L.). In a laboratory flow-through experiment we exposed M. edulis to the technical PCB mixture Aroclor 1248 for 21 d at three different enrichments of the unicellular green algae Chlamydomonas sp., 0.10, 0.16, and 0.32 mg particulate organic carbon (POC)/L. Tissue and water concentrations were determined for seven PCB congeners (International Union of Pure and Applied Chemistry [IUPAC] 52, 101, 105, 118, 138, 153, and 180), and 21-d bioaccumulation factors were calculated against total water concentrations. Contrary to what would be expected, an increase in algae enrichment from 0.10 to 0.32 mg POC/L resulted in an enhanced PCB accumulation by a factor of approx. 2. This increase in PCB accumulation was more pronounced for PCB congeners with lower hydrophobicity. These observations have implications for the design of laboratory accumulation studies and potentially for PCB accumulation and cycling in field populations of suspension-feeding mussels in response to changes in eutrophication status.

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“…Residues of mirex, PCBs, and dichlorodiphenyldichloroethylene (DDE), a metabolite of DDT, were reported in waterfowl by Kim et al (17), and it is interesting to question whether dermal absorption of water contaminants plays a significant role in waterfowl exposure. The oral route via ingestion of contaminated fish is commonly considered to be the major route of exposure to fish-eating birds since biomagnification of lipophilic water contaminants in fish has been frequently addressed (18)(19)(20)(21)(22)(23) (30) reported approximately 25 to 30% absorption of DDT in mice; however, mouse skin is considered to be more permeable than human skin, and problems concerning the use of animal models to predict human dermal absorption have been discussed by Bronaugh and Maibach (31). Bronaugh et al (32) related the effect of skin viability to the dermal metabolism of compounds applied topically, including DDT.…”

Section: Organochorinesmentioning

confidence: 99%

Dermal Exposure to Environmental Contaminants in the Great Lakes

Moody¹,

Chu²

1995

Environmental Health Perspectives

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This paper reviews the literature to determine the importance of the dermal route of exposure for swimmers and bathers using Great Lakes waters and summarizes the chemical water contaminants of concern in the Great Lakes along with relevant dermal absorption data. We detail in vivo and in vitro methods of quantifying the degree of dermal absorption and discuss a preference for infinite dose data as opposed to finite dose data. The basic mechanisms of the dermal absorption process, routes of chemical entry, and the environmental and physiological factors affecting this process are also reviewed, and we discuss the concepts of surface slick exposure to lipophilic compounds and the adsorption of contaminants to water sediment. After presenting mathematical constructs for calculating the degree of exposure, we present in vitro data concerning skin absorption of polyaromatic hydrocarbons adsorbed to Great Lakes water sediment to show that in a worst-case scenario exposure via the dermal route can be equally important to the oral route. We have concluded that prolonged exposure of the skin, especially under conditions that may enhance dermal absorption (e.g., sunburn) may result in toxicologically significant amounts of certain water contaminants being absorbed. It is recommended that swimming should be confined to public beaches, people should refrain from swimming if they are sunburned, and skin should be washed with soap as soon as possible following exposure. Future studies should be conducted to investigate the importance of the dermal exposure route to swimmers and bathers. -Environ Health Perspect 103(Suppl 9): 103-114 (1995)

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Bioaccumulation of super‐lipophilic chemicals in fish

Cited by 225 publications

References 25 publications

Dietary accumulation of C₁₂‐ and C₁₆‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)

Dietary accumulation of C₁₂‐ and C₁₆‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)

Enhanced accumulation of PCB congeners by baltic sea blue mussels, Mytilus edulis, with increased algae enrichment

Dermal Exposure to Environmental Contaminants in the Great Lakes

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Bioaccumulation of super‐lipophilic chemicals in fish

Cited by 225 publications

References 25 publications

Dietary accumulation of C12‐ and C16‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)

Dietary accumulation of C12‐ and C16‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)

Enhanced accumulation of PCB congeners by baltic sea blue mussels, Mytilus edulis, with increased algae enrichment

Dermal Exposure to Environmental Contaminants in the Great Lakes

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Dietary accumulation of C₁₂‐ and C₁₆‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)

Dietary accumulation of C₁₂‐ and C₁₆‐chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)