Bioaccumulation of hepatotoxins – A considerable risk in the Latvian environment

Bārda, Ieva; Kankaanpää, Harri; Puriņa, Ingrīda; Balode, Maija; Sjövall, Olli; Meriluoto, Jussi

doi:10.1016/j.envpol.2014.10.024

Cited by 21 publications

(15 citation statements)

References 44 publications

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“…MC is frequently found in a variety of organisms, for example, aquatic plants (Mitrovic et al, 2005), cladocerans (Ibelings et al, 2005), mussels (Barda et al, 2015), gastropods (Lance et al, 2008;Barda et al, 2015), fish (Ibelings et al, 2005;Papadimitriou et al, 2012;Vasconcelos et al, 2013) and mammals (Miller et al, 2010, van der Merwe et al, 2012. In higher organisms, MCs are actively and preferentially accumulated in the liver through organic anion transporting polypeptides (specifically,OATP1B1,OATP1B2,OATP1B3 and OATP1A2) involved in bile-acid transport in hepatocytes (Chorus & Bartram, 1999;Ito et al, 2008;McLellen & Manderville, 2017).…”

Section: Introductionmentioning

confidence: 99%

An examination of microcystin-LR accumulation and toxicity using tethered bilayer lipid membranes (tBLMs)

Facey

Steele

Violi

et al. 2019

Toxicon

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Microcystin-LR (MC-LR) is a potent cyanobacterial toxin responsible for animal and human poisonings worldwide. MC-LR is found in organisms throughout the foodweb, however there is conjecture regarding whether it biomagnifies. Few studies have investigated how MC-LR interacts with lipid membranes, a determinant of biomagnification potential. We tested whether 1 µM MC-LR irreversibly associates with lipid bilayers or causes the creation of pore defects upon short and long-term exposure. Using tethered bilayer lipid membranes (tBLMs), we observed an increase in membrane conduction in tBLMs, representing an interaction of microcystin-LR with the lipid bilayer and a change in membrane packing properties. However, there were minimal changes in membrane capacitance upon short and long-term exposure, and MC-LR exhibited a rapid off-rate. Upon 24 h exposure to the toxin, no lipophilic multimeric complexes were detected capable of altering the toxin's off-rate. There was no evidence of the creation of new pores. This study demonstrates that MC-LR does not irreversibly imbed itself into lipids membranes after short or long-term exposure and suggests MC-LR does not biomagnify through the food web via lipid storage.

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Section: Introductionmentioning

confidence: 99%

An examination of microcystin-LR accumulation and toxicity using tethered bilayer lipid membranes (tBLMs)

Facey

Steele

Violi

et al. 2019

Toxicon

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“…The prepared blood samples were analyzed using a microscopic method with an Olympus BX43 microscope at final magnification of 1000 X. Micronuclei (MN) were identified according to criteria adopted from [30,31]. MN should be: (1) smaller than the main nuclei, (2) round or oval in shape, (3) not linked to the main nuclei, (4) usually have the same staining intensity (purple/navy blue), (5) *The numbers or letters placed along some of the names of fishing grounds indicate the different geographic coordinates of the sampling place Table 1. Characteristics of Baltic herring and micronucleus frequencies in fish blood the same plane, and (6) the cell borders should be visible [31,32].…”

Section: Fish Blood Samples Analysismentioning

confidence: 99%

“…Nowadays, when the occurrence of these compounds is in the wider perspective taking their variety into account, it is not easy to identify one substance responsible for a given type of harmful effect or verify one factor causing the changes occurring in marine organisms. The changes in cells can be caused by ionizing radiation, heavy metals, petrochemical products, pharmaceuticals and pesticides [3][4][5][6][7][8][9][10][11][12][13]. In order to undertake evidence-based preventive and remedial actions it is important to verify and characterize the ecological risks generated by the presence of hazardous substances in the marine environment.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Changes in Herring from the Southern Baltic Sea

Gębka

Zalewska

Apanel

2020

Pol. J. Environ. Stud.

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A micronucleus test is a common test used as a biological indicator reflecting environmental genotoxicity caused by some of the hazardous substances' presence, and due to this it is recommended as one of the indicators for marine environmental status assessment. To determine the status of the environment, herring blood samples were collected in 2014-2017 in the southern Baltic Sea area at seven fishing grounds. The conducted analysis revealed that there is no significant correlation between the number of micronuclei in erythrocytes and sampling locations each year. This could be a result of a similar chemical status of the assessed areas as well as similar physico-chemical characteristics, but also the individual condition of the examined fish has to be taken into account as well as the their size parameters (length and weight). Statistical analysis showed statistically significant differences between the results over the years of research. The highest median values in all locations occurred in 2017, in which they were in the range of 0.57-1.37, probably as a result of longer lengths. The threshold value was exceeded in 2016 and 2017 in all locations, indicating inadequate status of the marine environment.

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“…Even though monitoring programs are in place to evaluate the concentration of cyanotoxins in fresh waters, prompt management of ecological and public health risk remains difficult due to the high spatiotemporal variability of the cyanobacterial proliferations. Freshwater mussels, and particularly D. polymorpha, are known to ingest phytoplankton and cyanobacteria and accumulate cyanotoxins at the laboratory [40,41] and in the field [42][43][44]. Therefore, the use of sentinel species to integrate and reveal early MC and BMAA contamination at low cyanobacterial or phytoplankton densities may allow a preventative management of contaminated sites.…”

Section: Cyanobacteriamentioning

confidence: 99%

Mussel as a Tool to Define Continental Watershed Quality

Ladeiro¹,

Barjhoux²,

Bigot-Clivot³

et al. 2017

Organismal and Molecular Malacology

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Bivalves appear as relevant sentinel species in aquatic ecotoxicology and water quality assessment. This is particularly true in marine ecosystems. In fact, several biomonitoring frameworks in the world used mollusks since several decades on the base of contaminant accumulation (Mussel Watch, ROCCH) and/or biological responses called biomarker (OSPAR) measurements. In freshwater systems, zebra and quagga mussels could represent alternative sentinels, which could be seen as the counterparts of mussel marine species. This chapter presents original studies and projects underlying the interest of these freshwater mussels for water quality monitoring based on contaminant accumulation and biomarker development measurements. These sentinel species could be used as a tool for chemical/biological monitoring of biota under the European water framework directive and for the development of effect-based monitoring tools.

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Bioaccumulation of hepatotoxins – A considerable risk in the Latvian environment

Cited by 21 publications

References 44 publications

An examination of microcystin-LR accumulation and toxicity using tethered bilayer lipid membranes (tBLMs)

An examination of microcystin-LR accumulation and toxicity using tethered bilayer lipid membranes (tBLMs)

Genotoxic Changes in Herring from the Southern Baltic Sea

Mussel as a Tool to Define Continental Watershed Quality

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