Bioaccumulation mechanism of organophosphate esters in adult zebrafish ( Danio rerio )

The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment

“…It is striking to note that, like the rodent model, optimized and standardized behavioral assessments are needed to increase the accuracy and reliability of the zebrafish model (Vaz et al, 2018), in parallel with its advancing application in PD studies. Nunes et al, 2017;Wang et al, 2018;Bastías-Candia et al, 2019;Feng et al, 2019;Vaccari et al, 2019;Joseph et al, 2020 Rotenone -Inhibition of the mitochondrial complex I activity -Increased ROS production -Reduced ATP production α-synuclein aggregation -Reduced dopamine level -Reduced mitochondrial calcium level -Increased activation of microglia and pro-inflammatory proteins -Motor impairments (reduced swimming speed, reduced distance traveled) -Anxiety -Depression -Olfactory dysfunction Gao et al, 2013;Wang et al, 2017;Lv et al, 2019;Hijaz and Volpicelli-Daley, 2020;Ramli et al, 2020;Ünal et al, 2020;Yurtsever et al, 2020 Anichtchik et al, 2008;Sallinen et al, 2010;Xi et al, 2010;Priyadarshini et al, 2013 Sheng et al, 2010;Prabhudesai et al, 2016;Sheng et al, 2018;Seegobin et al, 2020 neurotoxin inductions and PD-associated gene mutations on the zebrafish model of PD.…”

Novel Method for in Situ Monitoring of Organophosphorus Flame Retardants in Waters

“…This suggests that they may become incorporated in regulatory frameworks in the future. TCEP, TCPP, tri- n -butyl phosphate (TBP), and TBEP can be bioaccumulated in fish and can be transferred through the aquatic food web. − Concerns over human exposure to OPFRs have focused on endocrine disruption via disturbing steroidogenesis, inducing oxidative stress, or influencing thyroxine . Hence, accurate measurement and monitoring of OPFRs in aquatic systems are necessary to better understand their fate and biogeochemical behavior and to further evaluate their potential effect on ecosystems and human health.…”

Effects of polystyrene nanoplastics on the bioaccumulation, distribution and parental transfer of ethylhexyl salicylate

“…43,44 The liver is the main metabolic organ in fish and the intestine is the main excretory organ, and they can quickly absorb and metabolize accumulated pollutants to reduce the harm of the pollutants to the body when exogenous organic pollutants enter the organism, while the pollutants that are not metabolized or eliminated by the liver are transferred to various organs and tissues. 45 The results of this experiment indicated that the hepatobiliary system (liver-bile-intestine) might be of great significance to the metabolism and excretion of EHS in zebrafish.…”

“…As an important organ for material exchange in zebrafish, gill tissue has the potential to adsorb EHS from surrounding water, leading to a higher level of EHS accumulation. 45 However, although the gill tissue is directly exposed to the exposure solution, its cell permeability will become a limiting factor for EHS to penetrate into the gill tissue, which inhibits the gill tissue from endlessly accumulating pollutants. 46 Fitzsimmons et al 47 found that some organic chemicals could accumulate in the gill tissue through bloodstream transport, which might also be one of the reasons for the detection of EHS in gill tissue, although Fitzsimmons et al also found that the gill tissue had a partial elimination effect on organic chemicals.…”